PDR Prescription Depletion Replacementnone

Other Combinations

Brand: GPI

Other (e.g. tea bag)Other CombinationsOff Market
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Net Contents

60 Caplet(s)

Serving Size

2 Caplet(s)

Servings Per Container

30

Supplement Form

Other (e.g. tea bag)

Bar Code (UPC/SKU)

Not specified

Product Version

Item# 101013 72350601/280813/9101013 A

Label Analysis

Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.

21Active Ingredients

21 distinct active ingredients are disclosed in Supplement Facts.

100%Amount Transparency

Label includes a proprietary blend, so some individual amounts are not itemized.

18% Daily Value Coverage

18 ingredients report a %DV; 12 meet or exceed 100% DV.

This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.

Allergen Guide

Contains

  • Milk

Allergen flags are parsed automatically from the official label's claims and statements. Always verify against the physical product label before use, especially if you have a severe allergy.

Supplement Facts

Serving Size: 2 Caplet(s) · 1 per day

IngredientAmount Per Serving% Daily Value
Vitamin A(natural Mixed Carotenoids, Retinyl Palmitate)10000 IU200%
Vitamin C(Ascorbic Acid)300 mg500%
Vitamin D(Cholecalciferol)200 IU50%
Vitamin E(D-Alpha-Tocopheryl Succinate)200 IU667%
Thiamine(Thiamine Hydrochloride)30 mg2000%
Riboflavin20 mg1176%
Niacin(Niacinamide)20 mg100%
Vitamin B6(Pyridoxine Hydrochloride)30 mg1500%
Folate(Folic Acid)400 mcg100%
Vitamin B12(Cyanocobalamin)200 mcg3333%
Biotin100 mcg33%
Pantothenic Acid(D-Calcium Pantothenate)30 mg300%
Calcium({calcium} glycinate, Calcium Citrate, Calcium Malate, Dicalcium Phosphate)300 mg30%
Magnesium(Magnesium Citrate, Magnesium Oxide)300 mg75%
Zinc(Zinc Citrate, Zinc Oxide)15 mg100%
Selenium(Sodium Selenate)100 mcg143%
Chromium(Chromium Dinicotinate Glycinate)100 mcg83%
Potassium(Potassium Chloride)99 mg3%
Coenzyme Q-1010 mg
Trikatu(R) blend5 mg
Black Pepper
Ginger
Long Pepper
Probiotic Blend
Lactobacillus acidophilus
Lactobacillus plantarum
Bifidobacterium bifidum
Lactobacillus casei

Not Present

Other Ingredients

Microcrystalline CelluloseCroscarmellose SodiumStearic AcidMagnesium StearateSilicaPharmaceutical Glaze

Target Groups

Adult (18 - 50 Years)

Label Claims

All OtherStructure/Function

Directions & Suggested Use

Suggested/Recommended/Usage/Directions

DIRECTIONS: As a dietary supplement, take two caplets daily.

Warnings & Precautions

Precautions re: Pregnant or Nursing or Prescription Medications

CAUTION: Consult your physician prior to using this product if you are pregnant, nursing, or have any pre-existing medical conditions.

Precautions re: Children

Keep out of reach of children

Precautions re: All Other

Do not purchase if seal is broken

Precautions re: Allergies

CONTAINS MILK.

Storage

Storage

Protect from heat, light, and moisture Store at 59-86(0)F (15-30(0)C)

Formulation

Formula re: Contains

CONTAINS MILK.

FDA Statements

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Other Label Statements

General Statements: All Other Content

PDR helps replenish some of the most common nutrients lost by taking prescription and over-the-counter drugs.

General Statements: All Other Content

NOTE: The color, taste, and texture of this product may vary due to its natural ingredients and/or seasonal changes.

General Statements: All Other Content

Made in the USA

Seals/Symbols

GPi

General Statements: All Other Content

72350601/280813/9101013 A

Manufacturer & Distributor

Distributor

Vitamins Direct

West Palm Beach, FL, 33407

800-575-1634

Where to Buy Locally

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Research & Studies

  • Functional organization of the basal ganglia: therapeutic implications for Parkinson's disease

    JA Obeso, MC Rodríguez‐Oroz… - … : official journal of the …, 2008 - Wiley Online Library

    … (2) Indirect trisynaptic projections to the GPi via the globus pallidus … Dopaminergic depletion in Parkinson's disease disrupts the … Replacement therapy with standard levodopa creates a …

    20081,037 citations
  • The basal ganglia in Parkinson's disease: current concepts and unexplained observations

    JA Obeso, C Marin, C Rodriguez‐Oroz… - Annals of Neurology …, 2008 - Wiley Online Library

    … Potential conflict of interest: This article is part of a supplement … associated with dopamine depletion and replacement, and have … to the GPi is important and accounts for about half of GPi …

    2008540 citations
  • High‐frequency oscillations in the pallidum: a pathophysiological biomarker in Parkinson's disease?

    LA Johnson, JE Aman, Y Yu… - Movement …, 2021 - Wiley Online Library

    … HFO activity in the GPi, collecting spontaneous and … attenuated by dopamine replacement therapy provide compelling … presence in the GPi in the dopamine-depleted condition may also …

    202132 citations
  • A randomized clinical trial of coenzyme Q10 and GPI-1485 in early Parkinson disease

    Ninds Net-PD Investigators - Neurology, 2007 - neurology.org

    … from this review were coenzyme Q 10 and GPI-1485. … CoQ 10 is a widely used dietary supplement that appears safe … 10 or GPI-1485; or any clinically significant medical condition that …

    2007248 citations
  • Pallidal activity in Parkinson's disease patients with intraoperative dyskinesias

    P Pavlovsky, A Gamaleya, S Asriyants, A Tomskiy… - Clinical …, 2025 - Elsevier

    … Our findings suggest that the GPi is more uniformly responsive … result of synchronized bursting in the STN-GPe-GPi network. … -replacement therapy with levodopa on the GPe and GPi at …

    2025
  • Recommendations for deep brain stimulation device management during a pandemic

    S Miocinovic, JL Ostrem, MS Okun… - Journal of …, 2020 - journals.sagepub.com

    … For these patients, replacement of the IPG prior to depletion should be considered a very … it is possible that GPi and other brain targets also are at risk. Medical intensivists and general …

    202063 citations

Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2013-12-24. DSLD Label ID: 28703. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.