Bone Strength Formula With KoAct®

Suggested/Recommended/Usage/Directions

Dosage and Use ~ Take four capsules daily in divided doses with or without food, or as recommended by a healthcare practitioner.

Formula re: Contains

Life Extension brings you this exciting formulation with KoAct(R), a patented chelated form of calcium and collagen designed to maintain optimal bone health.

Formula re: Contains

Additional plant extracts from bamboo and dried plum have also been added for bone-protective minerals and polyphenols.2-8

Formula re: Contains

Bone Strength Formula with KoAct(R) contains the following ingredients: Vitamin D3 ~ Facilitates absorption of calcium into the bloodstream. ~ Regulates how much calcium enters and leaves bone tissue. ~ Helps regulate healthy cell division and differentiation. ~ Functions as a vital co-factor in bone mineralization through the absorption of calcium and phosphorus. Calcium ~ KoAct(R) is a unique patented chelated compound of calcium and hydrolyzed collagen peptides (type I collagen) designed to enhance collagen support and turnover while supporting optimal bone mineral density and strength. Magnesium ~ A critical component of our skeletin, with 50-60% of totally body magnesium found in bone ~ Positively influences the bone mineral matrix and its ability to metabolize minerals needed for repair and rebuilding. Silicon ~ Plays an important role in bone formation through the synthesis and/or stabilization of collagen. Dried Plu ~ Supports osteoblas (bone building cells) activity and function by upregulating cell-signaling compounds (Runx2, Osterix and IGF-1) and enhancing expression of an enzyme (lysyl oxidase) that is involved in collagen cross-linking. Boron ~ Impacts steroid hormone metabolism - affecting the levels of estrogens and testosterone.

Formula re: Contains

Calcium Collagen Oxide

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging.

Brand IP Statement(s) re: (c), (TM), (SM)

Foundation for Longer Life

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The use of diets high in collagen to improve bone health dates back to ancient cultures.

Brand IP Statement(s) re: (c), (TM), (SM)

KoAct(R) helps maintain bone strength and mineral density.1

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This remarkable ingredient allows for greater strength and flexibility, so your bones can absorb energy, reducing the risk of age-related injuries.

Brand IP Statement(s) re: (c), (TM), (SM)

If you need extra bone support, ask your healthcare professional how Bone Strength Formula with KoAct(R) can be part of a comprehensive nutritional program in conjunction with proper resistance exercise. Life Extension offers several mineral formulas that may complement Bone Strength Formula with KoAct(R) to ensure optimal mineral intake.

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If you have any questions about this, please call a Life Extension Health Advisor who can help to tailor a supplement program that meets your individual bone-care needs at 1-800-226-2370.

Brand IP Statement(s) re: (c), (TM), (SM)

KoAct(R) is a registered trademark of AIDP, Inc. Fruitex B(R) and OsteoBoron(R) are registered trademarks of VDF Futureceuticals, Inc. U.S. Patent No. 5,962,049.

Brand IP Statement(s) re: (c), (TM), (SM)

All contents Copyright (C) 1995-2013 Life Extension(R) All rights reserved

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References 1. Hooshmand 5 et al. Evidence for bone reversal properties of a calcium-collagen chelate, a novel dietary supplement. J Food Nutr Disor. 2013;2(1):1-6. 2. Jugdaohsingh R et al. Dietary Silicon Intake is Positively Associated with Bone Mineral Density In Men and Premenopausal Women of the Framingham Offspring Cohort. J Bone Miner Res. 2004;19(2):297-307. 3. Arjmandi BH, Khalil DA, Lucas EA, et al. Dried plums improve indices of bone formatino in postmenopausal women. J Womens Health Gend Based Med. 2002 Jan;11(1):61-8. 4. Bu SY, Lerner M, Stoecker BJ, et al. Dried plum polyphenols inhibit osteoclastogenesis by down-regulating NFATc1 and inflammatory mediators. Calcif Tissue Int. 2008 Jun;82(6):475-88. 5. Franklin M, BuSY, Lerner MR, et al. Dried Plum prevents bone loss in a male osteoporosis model via IGF-I and the RANK pathway. Bone.2006 Dec;39(6):1331-42. 6. Bu Sy, Hunt TS, Smith BJ. Dried plum polyphenols attenuate the detrimental effects of TNF-alpha on osteoblast function coincident with up-regulation of Runx2, osterix and IGF-I. J Nutr biochem. 2009 Jan;20(1):35-44. 7. Bu Sy, Lucas EA, Franklin M, et al. Comparison of dried plum supplementation and intermittent PTH in restoring bone in osteopenic orchidectomized rats. Osteoporos Int. 2007 Jul;18(7):931-42. 8. Deyhim F, Stoecker BJ, Brusewitz GH, Devareddy L, Arjimandi BH. Dried plum reverses bone loss in an osteopenic rat model of osteoporosis. Menopause. 2005 Nov;12(67):755-62.