5-MTHF 1 mg®

Vitamins

Brand: Thorne

CapsuleVitaminOn Market

Functions

Women's Health

Product label for 5-MTHF 1 mg — Click to view full label

Net Contents

60 Capsule(s)

Serving Size

1 Capsule(s)

Servings Per Container

Supplement Form

Capsule

Bar Code (UPC/SKU)

6 93749 12901 1

Product Version

B129 LB12912

Label Analysis

Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.

1Active Ingredients

Single-ingredient formula listed in Supplement Facts.

100%Amount Transparency

Every active ingredient discloses a specific amount per serving.

1% Daily Value Coverage

1 ingredients report a %DV; 1 meet or exceed 100% DV.

1Dietary Attributes

Label states: Gluten-Free.

This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.

Allergen Guide

Free From

Gluten

Allergen flags are parsed automatically from the official label's claims and statements. Always verify against the physical product label before use, especially if you have a severe allergy.

Supplement Facts

Serving Size: 1 Capsule(s) · 1–3 per day

Ingredient	Amount Per Serving	% Daily Value
Folate	1.7 mg DFE	425%
Extrafolate-S(L-5-Methyltetrahydrofolate)	1 mg	—

Not Present

Other Ingredients

Microcrystalline CelluloseHypromelloseLeucineSilicon Dioxide

Target Groups

Adult (18 - 50 Years)Gluten Free

Label Claims

NutrientAll OtherStructure/Function

Directions & Suggested Use

Suggested/Recommended/Usage/Directions

Suggested use: Take 1 capsule one to three times daily or as recommended by your healthcare practitioner.

Warnings & Precautions

Precautions re: All Other

Tamper evident: Use only if bottle is sealed.

Precautions re: Pregnant or Nursing or Prescription Medications

If pregnant, consult your health-care practitioner before using this product.

Storage

Store tightly sealed in a cool, dry place.

Formulation

Formulation re: Does NOT Contain

Gluten free

Formula re: Contains

Methylfolate

Formula re: Contains

This product uses Gnosis S.p.A.’s L-5-Methyltetrahydrofolate (Extra-folate-S).

FDA Statements

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Other Label Statements

General Statements: All Other Content

Foundational Mood Heart/Vessels

Seals/Symbols

Manufactured in the USA using US & imported ingredients

Brand IP Statement(s) re: (c), (TM), (SM)

Extrafolate-S is a registered trademark of Gnosis S.p.A.

Manufacturer & Distributor

Manufacturer

Thorne Research, Inc.

1-800-228-1966

Market Reference

$24.00 – $94.00· 17 listings

Thorne 5-MTHF 1 mg 60 Capsules
Mayo Clinic Store4.8(2200)
$24.00Lowest
Thorne Research 5-MTHF 1mg Folate Supplement 60 Capsules
Village Vitamin Store4.9(16)
$24.96
5-MTHF 1 mg 60 capsules
Life Extension5.0(4)
$24.00Lowest
Thorne Research 5-MTHF 5mg 60 Capsules
iHerb4.8(506)
$68.00
Thorne Research Methyl-Guard Plus 90 Capsules
Target4.8(1300)
$62.00
Thorne Metabolic Health Capsules
Thorne4.6(322)
$60.00
Thorne Research 5-HTP
Target4.6(690)
$39.00
Thorne Methyl-Guard Capsules
Thorne4.8(1000)
$56.00

Where to Buy Locally

Enter your city or ZIP code to find supplement & health stores in your area that may carry this product.

Showing representative supplement & health retailers — search above for stores in your area.

Village Green Apothecary
4.8 (489)
Vitamin & supplements store
5415 W Cedar Ln, Bethesda, MD 20814
Directions (301) 530-0800
Nutriessential
2.0 (16)
Vitamin & supplements store
5880 Collins Ave, Miami Beach, FL 33140
Directions (786) 623-4117

Research & Studies

Effect of L-Methylfolate Supplementation on Sleep for Patients with Reduced Methylenetetrahydrofolate Reductase Activity
AS Carmon, RJ Amato, SM Patel… - … of Dietary Supplements, 2024 - Taylor & Francis
… The goal of this study was to evaluate the effects of L-5-MTHF supplementation on sleep in … supplementation. For the sake of consistency, 5 mg of 5-L-MTHF manufactured by Thorne …
20243 citations
Methyltetrahydrofolate vs folic acid supplementation in idiopathic recurrent miscarriage with respect to methylenetetrahydrofolate reductase C677T and A1298C …
A Hekmatdoost, F Vahid, Z Yari, M Sadeghi… - PloS one, 2015 - journals.plos.org
… randomization to receive either 1mg folic acid or 1 mg 5-MTHF during the study period. The … with the supplements. The supplements were purchased from Thorne Research Company, ID…
201558 citations
The methylation, neurotransmitter, and antioxidant connections between folate and depression.
AL Miller - Alternative medicine review, 2008 - search.ebscohost.com
… , in the form of 5-MTHF, regenerates … , 5-MTHF "stands in" for BH4 at the enzyme level."* The chemical structures of BH4 and 5-MTHF are similar enough that eNOS will accept 5-MTHF …
2008420 citations
B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges
K Pentieva, A Caffrey, B Duffy, M Ward… - Proceedings of the …, 2025 - cambridge.org
… with habitually low riboflavin intake in the range 0·5–1 mg/d(65,66). Compared with the maternal … Maternal 5-MTHF supplementation associated with improved conflict solving ability (…
202522 citations
Comparative effectiveness of a prenatal medical food to prenatal vitamins on hemoglobin levels and adverse outcomes: a retrospective analysis
S Bentley, A Hermes, D Phillips, YA Daoud, S Hanna - Clinical therapeutics, 2011 - Elsevier
… In the present study, supplementation with a prenatal medical food containing L-methylfolate and high-dose vitamin B 12 may maintain hemoglobin levels and decrease rates of anemia …
201131 citations
Maternal folate nutrition and offspring health: evidence and current controversies
A Caffrey, H McNulty, RE Irwin, CP Walsh… - Proceedings of the …, 2019 - cambridge.org
… study found that FA supplement usage of >1 mg/d as … of mothers with FA intakes of 0·4 mg/d during the second and third … Maternal 5-MTHF supplementation associated with improved …
201973 citations

Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2023-02-21. DSLD Label ID: 284181. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.