Berberinenone

Other Combinations

Brand: Signature Supplements

CapsuleOther CombinationsOn Market

Functions

Blood Sugar Support

Product label for Berberine — Click to view full label

Net Contents

100 Capsule(s)

Serving Size

2–3 Capsule(s)

Servings Per Container

Supplement Form

Capsule

Bar Code (UPC/SKU)

Not specified

Product Version

Not Present

Label Analysis

Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.

2Active Ingredients

2 distinct active ingredients are disclosed in Supplement Facts.

100%Amount Transparency

Every active ingredient discloses a specific amount per serving.

1Dietary Attributes

Label states: Gluten-Free.

This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.

Supplement Facts

Serving Size: 2–3 Capsule(s) · 1 per day

Ingredient	Amount Per Serving
Berberine Hydrochloride(Indian Barberry Root Extract)	400 mg	—
Oregon Grape(Berberis aquifolium)	355 mg	—

Not Present

Other Ingredients

CelluloseDiatomaceous Earth

Target Groups

Adult (18 - 50 Years)Gluten FreeDairy FreeSugar Free

Label Claims

All OtherStructure/Function

Directions & Suggested Use

Suggested/Recommended/Usage/Directions

Directions: For adults, take 2 to 3 capsules daily, preferably before a meal.

Warnings & Precautions

Precautions re: Pregnant or Nursing or Prescription Medications

As a reminder, discuss the supplements and medications you take with your health care provider

Precautions re: Children

Keep out of reach of children store in a dry place and avoid excessive heat.

Storage

Keep out of reach of children store in a dry place and avoid excessive heat.

Formulation

Formulation re: Does NOT Contain

No: Chemical Fillers or Binders, Artificial coloring, artificial flavor, preservatives, yeast, corn, milk or milk derivatives, lactose, salt, sodium, soy, sugar, gluten, starch or wheat.

Formulation re: Other

From a GMP Facility

Formula re: Contains

Berberine is a golden yellow alkaloid obtained from the roots and stems of plants such as Indian barberry and Oregon grape. These berberine containing plants have been used throughout the world dating back over 3,000 years. It is favored among herbalists because it may help support overall cardiovascular health and glucose levels.

FDA Statements

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Manufacturer & Distributor

Distributor

Signature Supplements

P.O. Box 1112, San Clemente, CA

Market Reference

$7.50 – $71.40· 40 listings

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DG Health Berberine Ceylon Cinnamon Complex Herbal Supplement
Dollar General
$7.50Lowest
Enzymedica Berberine Phytosome 60 Capsules
Life Extension4.7(1000)
$18.56
Irwin Naturals Berberine-Body + Fat Burner
Hy-Vee4.6(376)
$27.99
Nature Made Berberine Phytosome Capsules
CVS Pharmacy4.4(94)
$49.99
Thorne Berberine 60 Capsules
Natures Food Markets4.7(4800)
$31.99

Where to Buy Locally

Enter your city or ZIP code to find supplement & health stores in your area that may carry this product.

Showing representative supplement & health retailers — search above for stores in your area.

The Vitamin Shoppe
4.3 (135)
Vitamin & supplements store
1505 Hilliard Rome Rd, Columbus, OH 43228
Directions (614) 878-6597
GNC
3.9 (26)
Vitamin & supplements store
1724 Stringtown Rd #16, Grove City, OH 43123
Directions (614) 317-9018
SupZilla
4.7 (73)
Vitamin & supplements store
3668 Fishinger Blvd, Hilliard, OH 43026
Directions (614) 363-4120
Vince's Muscle Shop
4.9 (116)
Vitamin & supplements store
828 Bethel Rd, Columbus, OH 43214
Directions (614) 266-4047
Bullfrog Nutrition Columbus
4.9 (160)
Vitamin & supplements store
1109 Worthington Woods Blvd, Columbus, OH 43085
Directions (614) 546-7848
The Vitamin Shoppe
4.4 (102)
Vitamin & supplements store
1540 Olentangy River Rd, Columbus, OH 43212
Directions (614) 299-2253
CVS
2.2 (124)
Vitamin & supplements store
3499 Clime Rd, Columbus, OH 43223
Directions (614) 276-2651
Basic Health Brands
4.6 (14)
Wholesaler
885 Claycraft Rd, Columbus, OH 43230
Directions (614) 863-3004

Research & Studies

Berberine suppresses colon inflammation via integrated modulation of host metabolism, microbial ecology, and innate immune signaling
Y Xiao, X Li, Y Fang, M Guo, M Shui, G Zhong… - …, 2026 - pmc.ncbi.nlm.nih.gov
… analysis between berberine and DSS group in myeloid and T cells. (B) Venn diagram illustrating the 87 downregulated gene signature shared by myeloid and T cells. This signature is …
20261 citations
A comprehensive compendium of berberine: sources, chemistry, and pharmacological activities
N Mohapatra, TG Singh, M Kumar… - Journal of the Science …, 2025 - Wiley Online Library
… signatures and fragment profiles associated with berberine and its metabolites. … found, including berberine and an excipient in pellets allowed the berberine to dissolve rapidly without …
2025
Polyherbal dietary supplementation for prediabetic adults: study protocol for a randomized controlled trial
T Feinberg, LS Wieland, LE Miller, K Munir, TI Pollin… - Trials, 2019 - Springer
… Berberine-induced AMPK activation is likely a consequence of … of berberine’s potential effects in the treatment of diabetes derive from stimulation of AMPK activity [79]. Berberine also …
201929 citations
Berberine as a bioactive alkaloid: multi-omics perspectives on its role in obesity management
B Zieniuk, M Pawełkowicz - Metabolites, 2025 - mdpi.com
… : combining berberine with metformin in diabetic mice produced a greater fall in blood glucose than either drug alone and generated a distinct microbiota signature—higher …
202520 citations
Efficacy and safety of berberine on the components of metabolic syndrome: a systematic review and meta-analysis of randomized placebo-controlled trials
D Liu, H Zhao, Y Zhang, J Hu, H Xu - Frontiers in Pharmacology, 2025 - frontiersin.org
… Notably, specific berberine refers to berberine with a purity greater than 95% and not … whether the results were influenced by berberine (berberine) dosage and intervention duration. …
202520 citations
Mitochondrial Health Through Nicotinamide Riboside and Berberine: Shared Pathways and Therapeutic Potential
F Visalli, M Capobianco, F Cappellani… - International …, 2026 - pmc.ncbi.nlm.nih.gov
… Both nicotinamide riboside (NR) and berberine (BBR) have emerged from very different … Across the NR studies included in this review, supplementation consistently increases …
20269 citations

Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2025-09-25. DSLD Label ID: 338613. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.