REMfresh Extra Strength®

Non-Nutrient / Non-Botanical

Brand: REMfresh

Other (e.g. tea bag)Non-Nutrient/Non-BotanicalOn Market
Click to view full label

Net Contents

12 Caplet(s)

Serving Size

1 Caplet(s)

Servings Per Container

12

Supplement Form

Other (e.g. tea bag)

Bar Code (UPC/SKU)

8 57150 00606 8

Product Version

44174404 H21 12478527 VC16-1247D REV.02.2022

Label Analysis

Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.

1Active Ingredients

Single-ingredient formula listed in Supplement Facts.

100%Amount Transparency

Every active ingredient discloses a specific amount per serving.

This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.

Allergen Guide

Contains

  • Wheat

Allergen flags are parsed automatically from the official label's claims and statements. Always verify against the physical product label before use, especially if you have a severe allergy.

Supplement Facts

Serving Size: 1 Caplet(s) · 1–2 per day

IngredientAmount Per Serving
UltraMel(Melatonin)5 mg

Not Present

Other Ingredients

Microcrystalline CelluloseCitric AcidHydroxypropyl MethylcelluloseCorn Starch, ModifiedTalcMagnesium StearateSilicon DioxideCellulose GumDextroseTitanium DioxidePolyvinyl AlcoholCelluloseBlue 1 LakePolyethylene GlycolMica-based Pearlescent PigmentGlycerinPolysorbate 80

Target Groups

Adult (18 - 50 Years)

Label Claims

All OtherStructure/Function

Directions & Suggested Use

Suggested/Recommended/Usage/Directions

Suggested Usage: Adults, take 1 caplet 30 to 90 minutes before intended bedtime. Do not exceed 2 caplets nightly. Intended for occasional sleeplessness.

Warnings & Precautions

Precautions re: Allergies

Contains: Wheat

Precautions re: Pregnant or Nursing or Prescription Medications

Warning: Consult a healthcare provider if you are experiencing long-term sleep difficulties, before use in children, before use in pregnant or lactating women, those with a medical condition, and those taking medication.

Precautions re: Children

Warning: Consult a healthcare provider if you are experiencing long-term sleep difficulties, before use in children, before use in pregnant or lactating women, those with a medical condition, and those taking medication.

Precautions re: All Other

Do not drive or operate machinery when taking melatonin.

Precautions re: Pregnant or Nursing or Prescription Medications

This product may be contraindicated for individuals taking corticosteroids.

Precautions re: Children

Keep out of reach of children.

Precautions re: All Other

Do not use if blister is torn or ripped or if there is any other evidence of tampering.

Precautions re: Allergies

Contains a bioengineered food ingredient.

Storage

Storage

Store in a cool, dry place.

Formulation

Formula re: Contains

Trouble sleeping? As we age and lead busier lives, our bodies produce less melatonin, the key ingredient we need to fall asleep and stay asleep. REMfresh, made with 99% ultrapure UltraMel melatonin, helps support the body’s own natural levels of melatonin for up to 7 hours.

Formulation re: Other

The REMfresh advantage Only REMfresh has the breakthrough melatonin IPP (Ion-Powered Pump) technology that promotes continuous release and absorption, allowing you to sleep longer and wake up ready to conquer the day. REMfrest 7 hour absorption, known as the MESA-WAVE, has been shown in a clinical trial. Fall asleep faster Stay asleep longer Improve sleep quality Wake up Refreshed

Formulation re: Other

Clinically tested

Formula re: Contains

Advanced Ion-powered melatonin

Formulation re: Other

7 hour absorption

Formulation re: Other

Fall asleep faster Say asleep longer Improve sleep quality Wake up REfreshed

Formula re: Contains

5 mg UltraMel Melatonin

FDA Statements

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Other Label Statements

General Statements: All Other Content

For illustrative purposes only. Vista Color

General Statements: All Other Content

REMfresh Extra Strength has 5 mg of melatonin per serving compared to the 0.5 mg and 2 mg per serving REMfresh products.

General Statements: All Other Content

Sleep Doctor Recommended Brand Among physicians with a certification in sleep medicine who recommended a modified release melatonin for sleep support. Lieberman 2021

Brand IP Statement(s) re: (c), (TM), (SM)

REMfresh is protected by U.S. patents No.: 8,691,275; 9,186,351; 9,241,926; 9,549,900; 10,226,447; 10,751,323.

General Statements: All Other Content

Questions/comments: Call us toll free 1-866-554-7071 or visit www.REMfresh.com

General Statements: All Other Content

REM Absorption Kinetics Trial (REMAKT) a pharmacokinetic trial of 5 mg REMfresh, not a sleep study. Approved after peer review and then published in Primary Care Companion for CNS Disorders, 2019.

General Statements: All Other Content

Individual results may vary.

Brand IP Statement(s) re: (c), (TM), (SM)

All trademarks are owned by Societe des Produits S.S., Vevey, Switzerland. Copyright 2022 Nestle.

Manufacturer & Distributor

Distributor

Nestle HealthCare Nutrition, Inc.

Bridgewater, NJ, 08807, USA

1-866-554-7071

Market Reference

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Where to Buy Locally

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Research & Studies

  • 36-Month Post Marketing Surveillance Report For REMfresh®, The First And Only Drug-Free Sleep Product Of Its Type1, Shows Excellent Safety And …

    L Lézard - lelezard.com

    … mg (Lite), 2 mg and 5mg (Extra Strength) UltraMel ® melatonin. UltraMel melatonin is a … REMfresh is a dietary supplement and is regulated under the Federal Dietary Supplement Health …

  • A randomized clinical trial of the impact of melatonin on influenza vaccine: Outcomes from the melatonin and vaccine response immunity and chronobiology study …

    RU Lee, NL Watson, GL Glickman, L White… - Human vaccines & …, 2024 - Taylor & Francis

    … Participants randomized to the treatment group were given REMfresh® 5 mg caplets (Nestle Health Science), an OTC melatonin supplement as recommended by a board-certified …

    20244 citations
  • Exogenous melatonin boosts vaccine-induced immunity in individuals with high pre-existing influenza immunity

    K Oda, J Danko, E Villasante… - Frontiers in …, 2025 - frontiersin.org

    … were enrolled after eligibility/health screening and informed written consent. … REMfresh ® 5mg caplets (Nestle Health Science), an over the counter (OTC) melatonin supplement…

    2025
  • Melatonin Supplementation in Young Adults: Its Prevalence and Effect on Nocturnal Sleep and Morning Cognition

    EMDG Wernette - 2023 - search.proquest.com

    … supplements in young adults with healthy sleep. The evidence on whether melatonin affects sleep in young individuals with health … We chose to use REMfresh brand melatonin because …

    2023
  • Influenza vaccine response is predicted by chronotype and differentially associated with pre-and post-vaccination sleep

    EM Harrison, RU Lee, CK Porter, SD Isidean… - … , & Immunity-Health, 2026 - Elsevier

    … Participants in the melatonin group were provided with melatonin caplets (REMfresh 5 mg, Nestle Health Science) at V1 and instructed to take them one hour before bedtime for 14 …

    2026
  • Effects of absorption kinetics on the catabolism of melatonin released from CAP-coated mesoporous silica drug delivery vehicles

    I Moroni, AE Garcia-Bennett - Pharmaceutics, 2021 - mdpi.com

    … that vary from 1.99 mg (REMfresh ® [8]) to 20 mg (Nutricology ® ). Melatonin can be purchased both as over-the-counter products and with a medical prescription, but its efficacy for …

    20216 citations

Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2023-08-24. DSLD Label ID: 289158. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.