REMfresh®
Non-Nutrient / Non-BotanicalBrand: REMfresh
Functions
Net Contents
36 Caplet(s)
Serving Size
1 Caplet(s)
Servings Per Container
36
Supplement Form
Other (e.g. tea bag)
Bar Code (UPC/SKU)
8 57150 00636 5
Product Version
P1187C02 C21 12473930 VC16-1248D
Label Analysis
Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.
Single-ingredient formula listed in Supplement Facts.
Every active ingredient discloses a specific amount per serving.
This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.
Allergen Guide
Contains
- Wheat
Allergen flags are parsed automatically from the official label's claims and statements. Always verify against the physical product label before use, especially if you have a severe allergy.
Supplement Facts
Serving Size: 1 Caplet(s) · 1–5 per day
| Ingredient | Amount Per Serving | |
|---|---|---|
| UltraMel(Melatonin) | 2 mg | — |
Not Present
Other Ingredients
Target Groups
Label Claims
Directions & Suggested Use
Suggested/Recommended/Usage/Directions
Suggested usage: Take 1 caplet 30 to 90 minutes before intended bedtime. For extra suppport, take 2 caplets nightly. Do not exceed 5 caplets nightly. Intended for occasional sleeplessness.
Warnings & Precautions
Precautions re: Allergies
Contains: Wheat
Precautions re: Children
Warning: Consult a healthcare provider if you are experiencing long-term sleep difficulties, before use in children, before use in pregnant or lactating women, those with a medical condition, and those taking medication.
Precautions re: Pregnant or Nursing or Prescription Medications
Warning: Consult a healthcare provider if you are experiencing long-term sleep difficulties, before use in children, before use in pregnant or lactating women, those with a medical condition, and those taking medication.
Precautions re: All Other
Do not drive or operate machinery when taking melatonin.
Precautions re: Pregnant or Nursing or Prescription Medications
This product may be contraindicated for individuals taking corticosteroids.
Precautions re: Children
Keep out of reach of children.
Precautions re: All Other
Do not use if blister is torn or ripped or if there is any other evidence of tampering.
Precautions re: Allergies
Contains a bioengineered food ingredient.
Storage
Storage
Store in a cool, dry place.
Formulation
Formula re: Contains
REMfresh, made with 99% ultrapure UltraMel melatonin, helps support the body's own natural levels of melatonin for up to 7 hours. The REMfresh advantage Only REMfresh has the breakthrough melatonin IPP (Ion-Powered Pump) technology that promotes continuous release and absorption, allowing you to sleep longer and wake up ready to conquer the day.
Formulation re: Other
REMfresh 7 hour absorption, known as the MESA-WAVE, has been shown in a clinical trial. Fall asleep faster Stay asleep longer Improve sleep quality Wake up REfreshed
Formulation re: Other
Clinically tested
Formula re: Contains
Advanced ion-powered melatonin
Formula re: Contains
REMfresh 2 mg UltraMel melatonin
FDA Statements
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Other Label Statements
General Statements: All Other Content
Trouble sleeping? As we age and lead busier lives, our bodies produce less melatonin, the key ingredient we need to fall asleep and stay asleep.
General Statements: All Other Content
Sleep doctor #1 recommended
General Statements: All Other Content
Vista Color
General Statements: All Other Content
Among primary care physicians with a certification in sleep disorders who recommended a non-prescription sleep aid brand. IQVIA ProVoice 2020 survey
Brand IP Statement(s) re: (c), (TM), (SM)
REMfresh is protected by U.S. patents No.: 8,691,275; 9,186,351; 9,241,926; 9,549,900; 10,226,447; 10,751,323.
General Statements: All Other Content
Questions/comments: Call us toll free 1-866-554-7071 Or visit www.REMfresh.com REM Absorption Kinetics Trial (REMAKT), a pharmacokinetic trial of 5 mg REMfresh, not a sleep study. Approved after peer review and then published in Primary Care Companion for CNS Disorders, 2019. Individual results may vary.
Brand IP Statement(s) re: (c), (TM), (SM)
All trademarks are owned by Societe des Produits Nestle S.A., Vevey, Switzerland. Copyright 2021 Nestle.
Manufacturer & Distributor
Distributor
Nestle HealthCare Nutrition, Inc.
Bridgewater, NJ, 08807, USA
1-866-554-7071
Market Reference
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Target4.4(745)$16.29Re-Fresh Vanilla Bean Tea Smoke Odor Eliminator 4 FL OZ 118ML Non-Aerosol (2x Pieces) | Triple Traders
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Target4.1(537)$16.79Refresh Tears PF Lubricant Eye Drops
Hy-Vee3.5(105)$16.99RepHresh Clean Balance Feminine Freshness 2-Step Kit
Instacart4.7(27)$7.17Lowest
Where to Buy Locally
Enter your city or ZIP code to find supplement & health stores in your area that may carry this product.
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ITL Health
5.0 (37)Vitamin & Supplements Shop
50 Broadway, London SW1H 0BL
Nutrapad Ltd –Pharmacy-friendly, Hydration, Immunity & Wellness Support - oxford street
5.0 (4)Vitamin & Supplements Shop
41 Bloomsbury Way, London WC1A 2SA
RightNutri
4.9 (78)Vitamin & Supplements Shop
26 Queenstown Rd, London SW8 3RX
The Pure Supplements
5.0 (3)Vitamin & Supplements Shop
Capital Business Centre, 22 Carlton Rd, South Croydon CR2 0BS
Research & Studies
0395 Clinical Practice Guideline For The Pharmacologic Treatment Of Chronic Insomnia In Adults: An American Academy Of Sleep Medicine Clinical Practice …
MJ Sateia, D Buysse, AD Krystal… - Journal of Sleep and …, 2017 - academic.oup.com
… SLEEP, Volume 40, Abstract Supplement, 2017 Methods: In an ongoing trial, eight healthy … The IPP-melatonin (ion powered pump melatonin delivery system; REMfresh) was devel…
20174 citations36-Month Post Marketing Surveillance Report For REMfresh®, The First And Only Drug-Free Sleep Product Of Its Type1, Shows Excellent Safety And …
L Lézard - lelezard.com
… REMfresh was designed as a hydrogel matrix tablet with its patented, scientifically … REMfresh is a dietary supplement and is regulated under the Federal Dietary Supplement Health and …
… , CLINICAL PHARMACOKINETICS EVALUATION OF AN ION POWERED PUMP MELATONIN DELIVERY SYSTEM IN HEALTHY NON-SMOKING ADULTS
DC Brodner, SM Shah - Sleep, 2017 - search.proquest.com
… The IPP-melatonin (ion powered pump melatonin delivery system; REMfresh) was developed to provide an exogenous melatonin pharmacokinetic (PK) profile that mimics normal …
20171 citations0388 CLINICAL EVALUATION OF THE ION POWERED PUMP (IPP) MELATONIN DELIVERY SYSTEM
DC Brodner, SM Shah - Sleep, 2017 - search.proquest.com
… in a regional military healthcare network, focusing on the … Melatonin supplementation has been shown to promote and … IPP-melatonin delivery system (REMfresh) was designed to …
2017Exogenous melatonin boosts vaccine-induced immunity in individuals with high pre-existing influenza immunity
K Oda, J Danko, E Villasante… - Frontiers in …, 2025 - frontiersin.org
… were enrolled after eligibility/health screening and informed written consent. … REMfresh ® 5mg caplets (Nestle Health Science), an over the counter (OTC) melatonin supplement…
2025A randomized clinical trial of the impact of melatonin on influenza vaccine: Outcomes from the melatonin and vaccine response immunity and chronobiology study …
RU Lee, NL Watson, GL Glickman, L White… - Human vaccines & …, 2024 - Taylor & Francis
… Participants randomized to the treatment group were given REMfresh® 5 mg caplets (Nestle Health Science), an OTC melatonin supplement as recommended by a board-certified …
20244 citations
Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2023-07-18. DSLD Label ID: 289153. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.
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