SAMe (S-Adenosylmethionine)

Suggested Use

Recommendations: As a dietary supplement; take 1 capsule; 1-2 times daily; between meals; or as directed by a health professional.

• 

  Pure Encapsulations SAMe 60 Capsules

  Pure For You4.4(70)

  $84.50
• 

  Pure Encapsulations SAMe 200mg Capsules

  www.pleijsalon.com4.4(70)

  $84.50
• 

  SAMe (S-Adenosylmethionine)

  Spectrum Innovations4.4(70)

  $10.00Lowest
• 

  SAMe (S Adenosylmethionine)

  Waters Wellness4.4(70)

  $84.50
• 

  Pure Encapsulations Adenosyl & Hydroxy B12 90 Veggie Caps

  Pure Prescriptions4.8(106)

  $31.00
• 

  Pure Encapsulations All In One 60 capsules

  Cosmetic2Go4.7(236)

  $26.68
• 

  Pure Encapsulations Daily Stress Formula 90 Capsules

  Pure Prescriptions4.9(58)

  $41.50
• 

  Pure Encapsulations PureGenomics Multivitamin

  Target4.5(199)

  $26.00

Enter your city or ZIP code to find supplement & health stores in your area that may carry this product.

Showing representative supplement & health retailers — search above for stores in your area.

• SWEET NUTRITION

  5.0 (6)

  Vitamin & supplements store

  610 Union Ave, Bronx, NY 10455

  Directions(347) 963-5264

• GNC

  3.8 (93)

  Vitamin & supplements store

  2958 3rd Ave, Bronx, NY 10455

  Directions(718) 292-4304

• Urban Nutrition Spot - Healthy Spot, Protein Plant Based Nutrition, Low calories, Smoothies, Waffles, Energy Drinks and More

  4.8 (16)

  Vitamin & supplements store

  197 Brook Ave, Bronx, NY 10454

  Directions(646) 945-5475

• Herbalife Ind. Dist. Nutrition Club The Nutrition House

  5.0 (6)

  Vitamin & supplements store

  609 Southern Blvd, Bronx, NY 10455

  Directions(646) 245-4737

• Parkchester Nutrition Club

  4.9 (18)

  Vitamin & supplements store

  1916 Benedict Ave, Bronx, NY 10462

  Directions(646) 372-9286

• NutriShop

  4.8 (83)

  Vitamin & supplements store

  1601 Williamsbridge Rd, Bronx, NY 10461

  Directions(347) 281-9989

• Nutri - Life Nutritional Center

  4.6 (17)

  Vitamin & supplements store

  1469 St Nicholas Ave, New York, NY 10033

  Directions(212) 740-2221

• The Vitamin Shoppe

  4.3 (126)

  Vitamin & supplements store

  661 W 181st St, New York, NY 10033

  Directions(212) 927-2849

• Three-month nutritional and lifestyle intervention reduces biological age: A pilot study using dna methylation clocks

  D Furness, P Taylor - Journal of the Australasian College of …, 2025 - search.informit.org

  … Pure Encapsulations (Global) and RN Labs (Australia), commercially available and formulated to support methylation, mitochondrial function, and cellular health… S-adenosylmethionine (…

  2025

• Synthesis of L-methionine-loaded chitosan nanoparticles for controlled release and their in vitro and in vivo evaluation

  PM Nuzaiba, S Gupta, S Gupta, SB Jadhao - Scientific Reports, 2023 - nature.com

  … , used in myriad of medical conditions have proved more efficacious over … SAMe is relatively expensive and unstable, its precursor, methionine can be a good choice for supplementation…

  202314 citations

• … of a novel oral formulation of S-adenosylmethionine (MSI-195) in healthy subjects: dose escalation, food effect and comparison to a commercial nutritional supplement …

  BR Cameron, L Ferreira, ID MacDonald - BMC Pharmacology and …, 2020 - Springer

  … 1600 mg of MSI-195 S-Adenosylmethionine (SAMe) was orally administered under fasted … the determination of plasma concentration of S-adenosylmethionine in a repeated-measure …

  202014 citations

• S-Adenosylmethionine (SAMe) for Central Nervous System Health: A Systematic Review

  KER Baden, H McClain, E Craig, N Gibson, JA Draime… - Nutrients, 2024 - mdpi.com

  … S-adenosylmethionine (SAMe) is a nutraceutical marketed … SAMe is produced in the liver from L-methionine and adenosine … use of all supplements and nutraceuticals, including SAMe. …

  202410 citations

• Protective role of S-adenosylmethionine on high fat/high cholesterol diet-induced hepatic and aortic lesions and oxidative stress in guinea pigs.

  İ Bingül, C Küçükgergin, AF Aydın… - General Physiology …, 2024 - search.ebscohost.com

  … The chemical, S-adenosyl-L methionine disulfate tosylate was donated by Pure Encapsulations, Inc. … In this study, SAM was injected to animals at the same time period with HFHC diet to …

  20248 citations

• The efficacy of S-adenosyl methionine and probiotic supplementation on depression: a synergistic approach

  H Ullah, A Khan, KRR Rengasamy, A Di Minno… - Nutrients, 2022 - mdpi.com

  … Routinely prescribed in Europe for decades and gaining popularity in the United States as a dietary supplement since 1998–1999, SAMe has been proposed for many medical …

  202245 citations

Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2019-01-07. DSLD Label ID: 185227. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.