SAMe (S-Adenosylmethionine)®

Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.

This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.

Allergen flags are parsed automatically from the official label's claims and statements. Always verify against the physical product label before use, especially if you have a severe allergy.

Serving Size: 1 Capsule(s) · 1–2 per day

Not Present

• 

  Pure Encapsulations SAMe 60 Capsules

  Target4.4(70)

  $84.50
• 

  Pure Encapsul Same 30CPS

  Spectrum Innovations4.4(70)

  $10.00Lowest
• 

  Pure Encapsulations SAMe 30 Capsules

  Bikeinn.com4.7(3)

  $62.99
• 

  Pure Encapsulations SP Ultimate

  PureFormulas.com4.7(27)

  $67.00
• 

  HM Complex Pure Encapsulations

  Pure Prescriptions4.8(14)

  $55.00
• 

  Pure Encapsulations PS Plus 60 Capsules

  Target4.9(9)

  $97.00
• 

  Energy Xtra Pure Encapsulations

  www.pleijsalon.com4.8(72)

  $15.20
• 

  Pure Encapsulations Methyl Assist Capsules

  Instacart4.8(68)

  $53.99

Enter your city or ZIP code to find supplement & health stores in your area that may carry this product.

Showing representative supplement & health retailers — search above for stores in your area.

• Love-R-Health Foods

  4.1 (10)

  Vitamin & supplements store

  220 W 3rd St, La Junta, CO 81050

  Directions(888) 384-4540

• Nutritional Fuel

  5.0 (436)

  Vitamin & supplements store

  444 S Prairie Ave, Pueblo, CO 81005

  Directions(719) 369-7070

• COLORADO DISCOUNT NUTRITION

  5.0 (678)

  Vitamin & supplements store

  445 E Cheyenne Mountain Blvd Ste D, Colorado Springs, CO 80906

  Directions(719) 465-3291

• 5 Star Nutrition Fort Carson

  4.9 (322)

  Vitamin & supplements store

  4451 Venetucci Blvd #140, Colorado Springs, CO 80906

  Directions(719) 576-9234

• Three-month nutritional and lifestyle intervention reduces biological age: A pilot study using dna methylation clocks

  D Furness, P Taylor - Journal of the Australasian College of …, 2025 - search.informit.org

  … Pure Encapsulations (Global) and RN Labs (Australia), commercially available and formulated to support methylation, mitochondrial function, and cellular health… S-adenosylmethionine (…

  2025

• Synthesis of L-methionine-loaded chitosan nanoparticles for controlled release and their in vitro and in vivo evaluation

  PM Nuzaiba, S Gupta, S Gupta, SB Jadhao - Scientific Reports, 2023 - nature.com

  … , used in myriad of medical conditions have proved more efficacious over … SAMe is relatively expensive and unstable, its precursor, methionine can be a good choice for supplementation…

  202314 citations

• … of a novel oral formulation of S-adenosylmethionine (MSI-195) in healthy subjects: dose escalation, food effect and comparison to a commercial nutritional supplement …

  BR Cameron, L Ferreira, ID MacDonald - BMC Pharmacology and …, 2020 - Springer

  … 1600 mg of MSI-195 S-Adenosylmethionine (SAMe) was orally administered under fasted … the determination of plasma concentration of S-adenosylmethionine in a repeated-measure …

  202014 citations

• S-Adenosylmethionine (SAMe) for Central Nervous System Health: A Systematic Review

  KER Baden, H McClain, E Craig, N Gibson, JA Draime… - Nutrients, 2024 - mdpi.com

  … S-adenosylmethionine (SAMe) is a nutraceutical marketed … SAMe is produced in the liver from L-methionine and adenosine … use of all supplements and nutraceuticals, including SAMe. …

  202410 citations

• Protective role of S-adenosylmethionine on high fat/high cholesterol diet-induced hepatic and aortic lesions and oxidative stress in guinea pigs.

  İ Bingül, C Küçükgergin, AF Aydın… - General Physiology …, 2024 - search.ebscohost.com

  … The chemical, S-adenosyl-L methionine disulfate tosylate was donated by Pure Encapsulations, Inc. … In this study, SAM was injected to animals at the same time period with HFHC diet to …

  20249 citations

• The efficacy of S-adenosyl methionine and probiotic supplementation on depression: a synergistic approach

  H Ullah, A Khan, KRR Rengasamy, A Di Minno… - Nutrients, 2022 - mdpi.com

  … Routinely prescribed in Europe for decades and gaining popularity in the United States as a dietary supplement since 1998–1999, SAMe has been proposed for many medical …

  202247 citations

Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2019-01-07. DSLD Label ID: 185227. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.