SAMe (S-Adenosylmethionine)®

Non-Nutrient / Non-Botanical

Brand: Pure Encapsulations

CapsuleNon-Nutrient/Non-BotanicalOff Market

Product label for SAMe (S-Adenosylmethionine) — Click to view full label

Net Contents

60 Capsule(s)

Serving Size

1 Capsule(s)

Servings Per Container

Supplement Form

Capsule

Bar Code (UPC/SKU)

7 66298 01504 0

Product Version

code: SAM6 v4

Label Analysis

Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.

1Active Ingredients

Single-ingredient formula listed in Supplement Facts.

100%Amount Transparency

Every active ingredient discloses a specific amount per serving.

This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.

Supplement Facts

Serving Size: 1 Capsule(s) · 1–2 per day

Ingredient	Amount Per Serving
SAMe(S-Adenosyl-L-Methionine Disulfate Tosylate)	200 mg	—

Not Present

Other Ingredients

Vegetarian Capsulehypoallergenic Plant FiberCalcium OxideAscorbyl PalmitateCalcium Chloride

Target Groups

Adult (18 - 50 Years)No Allergies

Label Claims

All Other

Directions & Suggested Use

Suggested/Recommended/Usage/Directions

Recommendations: As a dietary supplement, take 1 capsule, 1-2 times daily, between meals, or as directed by a health professional.

Warnings & Precautions

Precautions re: All Other

Tamper Resistant: Use only if safety seal is intact.

Precautions re: Pregnant or Nursing or Prescription Medications

Warning: If you are pregnant or lactating, have any health condition or are taking any medication, particularly if you have bipolar disorder or are taking antidepressant medication, consult your health professional before use.

Precautions re: Children

Keep out of the reach of children.

Storage

Store sealed in a cool dry area

Formulation

Formulation re: Does NOT Contain

Commitment to Quality Program Sourced and manufactured to avoid: Artificial additives Allergens GMOs Environmental contaminants Added excipients www.PureEncapsulations.com/QualityControl See supplement facts for specific product details

Formulation re: Other

Hypoallergenic

FDA Statements

FDA Statement of Identity

Dietary Supplement

Other Label Statements

General Statements: All Other Content

Acid-resistant capsules with pH targeted release

General: Product/Version Code

v4 code: SAM6

Manufacturer & Distributor

Manufacturer

Pure Encapsulations, Inc.

Sudbury, MA, USA

1-800-753-2277

Market Reference

$10.00 – $107.00· 40 listings

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Energy Xtra Pure Encapsulations
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$15.20
Aller Essentials Pure Encapsulations
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$39.00

Where to Buy Locally

Enter your city or ZIP code to find supplement & health stores in your area that may carry this product.

Showing representative supplement & health retailers — search above for stores in your area.

Primal Nutrition
4.7 (75)
Vitamin & supplements store
8114 Roosevelt Blvd, Philadelphia, PA 19152
Directions (215) 613-5693
The Vitamin Shoppe
4.6 (121)
Vitamin & supplements store
2383 Cottman Ave Suite 38B, Philadelphia, PA 19149
Directions (215) 331-2023
Ares Nutrition Philadelphia
5.0 (240)
Vitamin & supplements store
3354 Grant Ave, Philadelphia, PA 19114
Directions (215) 464-5976
Fusion Nutrition Center
5.0 (81)
Vitamin & supplements store
2801 Grant Ave, Philadelphia, PA 19114
Directions (215) 821-3451
Philly Gainz
4.9 (85)
Vitamin & supplements store
6011 Ridge Ave C1, Philadelphia, PA 19128
Directions (215) 921-1951
Holly Hill Health Foods, Inc.
4.7 (160)
Vitamin & supplements store
1200 Welsh Rd Ste N, North Wales, PA 19454
Directions (215) 361-7770
GNC
4.1 (50)
Vitamin & supplements store
4640 E Roosevelt Blvd F2, Philadelphia, PA 19124
Directions (215) 288-9130
The Vitamin Shoppe
4.3 (169)
Vitamin & supplements store
1701 Chestnut St, Philadelphia, PA 19103
Directions (215) 568-4898

Research & Studies

Three-month nutritional and lifestyle intervention reduces biological age: A pilot study using dna methylation clocks
D Furness, P Taylor - Journal of the Australasian College of …, 2025 - search.informit.org
… Pure Encapsulations (Global) and RN Labs (Australia), commercially available and formulated to support methylation, mitochondrial function, and cellular health… S-adenosylmethionine (…
2025
Synthesis of L-methionine-loaded chitosan nanoparticles for controlled release and their in vitro and in vivo evaluation
PM Nuzaiba, S Gupta, S Gupta, SB Jadhao - Scientific Reports, 2023 - nature.com
… , used in myriad of medical conditions have proved more efficacious over … SAMe is relatively expensive and unstable, its precursor, methionine can be a good choice for supplementation…
202314 citations
… of a novel oral formulation of S-adenosylmethionine (MSI-195) in healthy subjects: dose escalation, food effect and comparison to a commercial nutritional supplement …
BR Cameron, L Ferreira, ID MacDonald - BMC Pharmacology and …, 2020 - Springer
… 1600 mg of MSI-195 S-Adenosylmethionine (SAMe) was orally administered under fasted … the determination of plasma concentration of S-adenosylmethionine in a repeated-measure …
202014 citations
S-Adenosylmethionine (SAMe) for Central Nervous System Health: A Systematic Review
KER Baden, H McClain, E Craig, N Gibson, JA Draime… - Nutrients, 2024 - mdpi.com
… S-adenosylmethionine (SAMe) is a nutraceutical marketed … SAMe is produced in the liver from L-methionine and adenosine … use of all supplements and nutraceuticals, including SAMe. …
202410 citations
Protective role of S-adenosylmethionine on high fat/high cholesterol diet-induced hepatic and aortic lesions and oxidative stress in guinea pigs.
İ Bingül, C Küçükgergin, AF Aydın… - General Physiology …, 2024 - search.ebscohost.com
… The chemical, S-adenosyl-L methionine disulfate tosylate was donated by Pure Encapsulations, Inc. … In this study, SAM was injected to animals at the same time period with HFHC diet to …
20249 citations
The efficacy of S-adenosyl methionine and probiotic supplementation on depression: a synergistic approach
H Ullah, A Khan, KRR Rengasamy, A Di Minno… - Nutrients, 2022 - mdpi.com
… Routinely prescribed in Europe for decades and gaining popularity in the United States as a dietary supplement since 1998–1999, SAMe has been proposed for many medical …
202247 citations

Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2019-02-25. DSLD Label ID: 184921. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.