SAMe 200®
Non-Nutrient / Non-BotanicalBrand: ProThera
Net Contents
30 Enteric Coated Tablet(s) in Foil Blister Pack
Serving Size
1–6 Tablet(s)
Servings Per Container
Not specified
Supplement Form
Tablet or Pill
Bar Code (UPC/SKU)
8 28054 01020 8
Product Version
SAM rev100112A
Label Analysis
Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.
Single-ingredient formula listed in Supplement Facts.
Every active ingredient discloses a specific amount per serving.
This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.
Allergen Guide
Contains
- Milk
- Egg
- Fish
- Shellfish
- Tree Nuts
- Peanut
- Wheat
- Soy
- Gluten
Allergen flags are parsed automatically from the official label's claims and statements. Always verify against the physical product label before use, especially if you have a severe allergy.
Supplement Facts
Serving Size: 1–6 Tablet(s) · 1 per day
| Ingredient | Amount Per Serving | |
|---|---|---|
| S-Adenosyl L-Methionine | 200 mg | — |
| S-Adenosyl L-Methionine Tosylate Disulfate | 400 mg | — |
Not Present
Other Ingredients
Target Groups
Label Claims
Directions & Suggested Use
Suggested/Recommended/Usage/Directions
Suggested use: 1 to 6 tablets daily on an empty stomach.
Warnings & Precautions
Precautions re: All Other
Warning: Individuals being treated for neurological conditions, including those using prescribed medications such as antidepressants, serotonin reuptake inhibitors, and MAO inhibitors, should consult their healthcare professional before using this product. Individuals with bipolar disorder or manic depression should not take SAMe unless under medical supervision.
Precautions re: Pregnant or Nursing or Prescription Medications
Warning: Individuals being treated for neurological conditions, including those using prescribed medications such as antidepressants, serotonin reuptake inhibitors, and MAO inhibitors, should consult their healthcare professional before using this product.
Precautions re: All Other
Do not use if outer seal of blister pack is broken.
Precautions re: Children
Keep out of reach of children.
Storage
Storage
Store in a cool, dry place (59(0)F-85(0)F) away from direct light.
Formulation
Formula re: Contains
200 mg Elemental SAMe s-adenosyl l-methionine
Formulation re: Does NOT Contain
Free of the following common allergens: milk/casein, egg, fish, shellfish, tree nuts, peanuts, wheat/gluten, and soybeans.
Formula re: Contains
Each tablet contains a full 200 mg of elemental SAMe from 400 mg SAMe tosylate disulfate.
FDA Statements
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Other Label Statements
Brand IP Statement(s) re: (c), (TM), (SM)
ProThera, Inc.
General Statements: All Other Content
ProThera's SAMe 200 is provided in individual foil blister-packets to maximize product stability.
General: Product/Version Code
SAM rev100112A
General Statements: All Other Content
Made in Italy
General Statements: All Other Content
ProThera provides pharmaceutical grade, stabilized SAMe manufactured under low temperature and low humidity conditions. An enteric tablet coating resistant to gastric acidity helps to further ensure a biologically active product.
General Statements: All Other Content
SAMe (S-Adenosylmethionine) is a derivative of the essential amino acid methionine and is formed by combining ATP with methionine.
General Statements: All Other Content
SAMe has a long history of clinical use with proven benefits for brain metabolism, joint function, and liver detoxification. Some of the reported beneficial actions of SAMe include: Joint and connective tissue strength SAMe supports production of healthy connective tissue and joint structures by contributing its sulfur component for transulfuration processes that help form glucosamine and chondroitin sulfates, critical components of connective tissues. Brain metabolism SAMe serves as a major source of methyl groups used by the brain in the synthesis of neurotransmitters such as serotonin, L-dopa, dopamine, and related hormones involved in mood regulation. Liver function Metabolism of SAMe supports synthesis of glutathione and glutathione-dependant enzymes (glutathione peroxidase and glutathione-S-transferase), which are important antioxidants used in liver detoxification processes.
Manufacturer & Distributor
Distributor
ProThera, Inc.
Reno, NV, 89521
888-488-2488
Market Reference
Protocol For Life Balance SAMe 200 mg 60 Capsules
OC Whole Family Wellness4.9(75)$28.67Klaire Labs SAMe 200 Hypoallergenic S-adenosylme
SFI Health5.0(1)$49.99NOW Foods SAMe 200 mg 60 Capsules
Vitacost.com4.7(447)$45.92SAMe 200
Pure Prescriptions$59.99Bestvite's SAMe 200mg 60 Tablets
Walmart - BESTVITE INC4.7(343)$24.99Pure Encapsulations SAMe 60 Capsules
iHerb4.4(70)$84.50Jarrow Formulas SAM-e 200 mg Tablets
Walsh Natural Health4.6(444)$18.49LowestProtocol for Life Balance SAMe 200 mg 60 Tablets
Curated Wellness$40.00
Where to Buy Locally
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Good Life Nutrition
4.8 (22)Vitamin & supplements store
437 Kiely Blvd, San Jose, CA 95117
SNAC | Sport Supplements
4.2 (5)Vitamin & supplements store
1100 Industrial Rd Ste 12, San Carlos, CA 94070
Palmetto Superfoods - Santana Row
4.3 (176)Health food restaurant
3055 Olin Ave #1010, San Jose, CA 95128
Whole Foods Market
4.4 (1456)Grocery store
150 E McKinley Ave, Sunnyvale, CA 94086
Walgreens
3.3 (83)Vitamin & supplements store
200 N Winchester Blvd Walgreens, Santa Clara, CA 95050
Revive Body MD
4.6 (128)Weight loss service
636 E Santa Clara St, San Jose, CA 95112
Whole Foods Market
4.3 (2530)Grocery store
20955 Stevens Creek Blvd, Cupertino, CA 95014
Walgreens
2.7 (135)Vitamin & supplements store
105 E El Camino Real, Sunnyvale, CA 94087
Research & Studies
The Health Detective's 456 Most Powerful Healing Secrets (Volume 2 of 2)(EasyRead Comfort Edition)
N Kathryn Fuchs Ph D - books.google.com
… Your doctor may know of a supplement company that has high-quality hormones. ProThera (in the Resources section) is … This study used 120mg of sage a day, the same amount found …
The Health Detective's 456 Most Powerful Healing Secrets (Volume 2 of 2)(EasyRead Edition)
N Kathryn Fuchs Ph D - books.google.com
… Your doctor may know of a supplement company that has high-quality hormones. ProThera (in … This study used 120mg of sage a day, the same amount found in the formulas listed in the …
Black Maitake mushroom (Grifola frondosa) extract exerts anti-cancer effects and enhances the efficacy of chemotherapeutic drugs in 2D and 3D models of …
S DeMarco, S Regonda, S Pandey - Journal of Complementary …, 2026 - degruyterbrill.com
… led to increased interest in natural health products (NHPs) as … Maitake Odaira Extract – Prothera (BMOE) manufactured by … were taken at a magnification of 200× using the LAS AF6000 …
2026The Health Detective's 456 Most Powerful Healing Secrets (Volume 2 of 2)(EasyRead Large Bold Edition)
N Kathryn Fuchs Ph D - books.google.com
… But phytoestrogens in foods and supplements are not the same. There’s simply no way to duplicate … Soy-based supplements often contain high amounts of isoflavones without the same …
Evaluating the anticancer potential of black maitake extract in A375 human malignant melanoma cells
J Mathews, S Regonda, A Grewal… - Journal of …, 2026 - degruyterbrill.com
… This study evaluates Black Maitake Odaira Extract Prothera (… Fluorescent images were taken at 200× magnification using … the therapeutic promise of natural health products like BME, …
2026Probiotics and disease: a comprehensive summary—part 1, mental and neurological health
KE Dolan, HJ Finley, CM Burns… - Integrative Medicine …, 2016 - pmc.ncbi.nlm.nih.gov
… In part 1, we explore the role of probiotics in balancing mental health and neurological issues. Conditions in mental health include anxiety, depression, attention-deficit/hyperactivity …
201630 citations
Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2017-02-24. DSLD Label ID: 71135. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.
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