5-MTHF®

Vitamins

Brand: Priority One Nutritional Supplements

CapsuleVitaminOff Market

Product label for 5-MTHF — Click to view full label

Net Contents

120 Capsule(s)

Serving Size

1 Capsule(s)

Servings Per Container

Not specified

Supplement Form

Capsule

Bar Code (UPC/SKU)

8 15354 02179 9

Product Version

1650-6955R6

Label Analysis

Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.

1Active Ingredients

Single-ingredient formula listed in Supplement Facts.

100%Amount Transparency

Every active ingredient discloses a specific amount per serving.

1% Daily Value Coverage

1 ingredients report a %DV; 1 meet or exceed 100% DV.

1Dietary Attributes

Label states: Non-GMO.

This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.

Supplement Facts

Serving Size: 1 Capsule(s) · 1 per day

Ingredient	Amount Per Serving	% Daily Value
Folate(L-5-Methyltetrahydrofolate)	1000 mcg	250%
L-5-Methyltetrahydrofolate	1370 mcg	—

Not Present

Other Ingredients

Rice ChelateCapsule

Target Groups

Adult (18 - 50 Years)

Label Claims

NutrientAll OtherStructure/Function

Directions & Suggested Use

Suggested/Recommended/Usage/Directions

Recommendations: Take one (1) capsule daily, or as directed by your physician.

Warnings & Precautions

Precautions re: Pregnant or Nursing or Prescription Medications

Warning: If you are pregnant or breast feeding, consult your physician before using this product.

Precautions re: Children

Keep out of reach of children.

Storage

Keep container tightly closed, store in a cool, dry place.

Formulation

Formulation re: Does NOT Contain

Contains no preservatives. Bisphenol-A (BPA) & Phthalate Free

Formula re: Contains

L-5-Methyltetrahydrofolate Calcium

Formulation re: Does NOT Contain

Non-GMO

FDA Statements

FDA Statement of Identity

A Dietary Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Other Label Statements

Seals/Symbols

GMP Certified

General Statements: All Other Content

Priority One Nutritional Supplements Inc since 1988

General Statements: All Other Content

For professional use only.

Manufacturer & Distributor

Distributor

Priority One Nutritional Supplements, Inc.

Manufacturer

First Priority Manufacturing, Inc.

2681 Delta Ring Road, Ferndale, WA, 98248

Market Reference

$18.00 – $169.99· 40 listings

Priority One Complete One Daily 90 Capsules
Priority One Vitamins5.0(1)
$66.00
Priority Folate — Optifolin+ Active L-Methylfolate | Priority One (30) count
Priority One Vitamins5.0(1)
$24.20
Priority One Fibro Plus 90 Veggie Caps
Priority One Vitamins5.0(2)
$29.00
Priority One Folate Methylation 60 Capsules
Priority One Vitamins4.5(2)
$54.00
Priority One Daily Foundations Bundle
Priority One Vitamins
$130.00
Priority One Vitamins Priority Folate 60 Capsules
GoSupps.com
$109.99
Priority One Immune Defense Bundle — Mushrooms & Multi-Ingredient Immune Support
Priority One Vitamins
$60.00
Priority One Thyroid Plus 120 Capsules
Priority One Vitamins4.7(28)
$111.10

Where to Buy Locally

Enter your city or ZIP code to find supplement & health stores in your area that may carry this product.

Showing representative supplement & health retailers — search above for stores in your area.

Village Green Apothecary
4.8 (489)
Vitamin & supplements store
5415 W Cedar Ln, Bethesda, MD 20814
Directions (301) 530-0800

Research & Studies

Safety of monosodium salt of l‐5‐methyltetrahydrofolic acid as a novel food pursuant to Regulation (EU) 2015/2283 and the bioavailability of folate from this source in …
EFSA Panel on Nutrition, Novel Foods and Food … - EFSA …, 2023 - Wiley Online Library
… (5-MTHF), glucosamine salt as an alternative source of folate added for nutritional purposes to food supplements. … mg/day, which equates to 1 mg 5-MTHF and 0.8 mg glucosamine) are …
20236 citations
[6S]-5-Methyltetrahydrofolic Acid and Folic Acid Pregnancy Diets Differentially Program Metabolic Phenotype and Hypothalamic Gene Expression of Wistar …
E Pannia, R Hammoud, R Simonian, E Arning… - Nutrients, 2020 - mdpi.com
… reduction of FA or 5-MTHF naturally present in foods. 5-MTHF participates in the biosynthesis of … pregnancy and long-term outcomes should be a priority to inform food regulatory actions …
202016 citations
How increased dietary folic acid intake impacts health outcomes through changes in inflammation, angiogenesis, and neurotoxicity
S Gunnala, LM Buhlman, NM Jadavji - Nutrients, 2025 - mdpi.com
… (5-MTHF) [1]. Homocysteine is typically methylated from 5-MTHF with the assistance of vitamin … Understanding what happens in conditions of overnutrition has not been a priority outside …
20257 citations
Folate bioavailability: UK food standards agency workshop report
P Sanderson, H McNulty, P Mastroiacovo… - … Journal of Nutrition, 2003 - cambridge.org
… of folate bioavailability of whole diets should be a high priority for future research. … folate: dietary counselling to add around 200 mg natural folate/d; 200 mg folic acid/d; 200 mg 5-MTHF/d…
2003109 citations
Folic acid supplementation in prevention of neural tube defects
E Jasovic Siveska - Reprod Syst Sex Disord 4, 2015 - eprints.uklo.edu.mk
… FA are converted to 5-MTHF. A nature-identical folate of 5-MTHF as 6S-5-MTHF has been … environmental risk factors is a crucial policy priority, including preconceptional care and whole …
20152 citations
B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges
K Pentieva, A Caffrey, B Duffy, M Ward… - … of the Nutrition Society, 2025 - cambridge.org
… Maternal 5-MTHF supplementation associated with improved conflict solving ability (… and fetal growth and maintain maternal health is an urgent priority. Another challenge is the limited …
202522 citations

Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2020-09-25. DSLD Label ID: 235579. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.