SAM-e S-Adenosylmethionine 200 mg®

Non-Nutrient / Non-Botanical

Brand: PhysioLogics

Tablet or PillNon-Nutrient/Non-BotanicalOff Market
Click to view full label

Net Contents

30 Enteric Coated Tablet(s)

Serving Size

2 Tablet(s)

Servings Per Container

15

Supplement Form

Tablet or Pill

Bar Code (UPC/SKU)

7 16963 07116 1

Product Version

PROD. NO. 7116 B36221 04D

Label Analysis

Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.

1Active Ingredients

Single-ingredient formula listed in Supplement Facts.

100%Amount Transparency

Every active ingredient discloses a specific amount per serving.

1Dietary Attributes

Label states: Gluten-Free.

This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.

Supplement Facts

Serving Size: 2 Tablet(s) · 3 per day

IngredientAmount Per Serving
S-Adenosylmethionine400 mg

Not Present

Other Ingredients

CelluloseMannitolPolymethacrylateVegetable Magnesium StearateContains Less Than 2% of

Target Groups

Adult (18 - 50 Years)Gluten FreeDairy FreeSugar Free

Label Claims

All OtherStructure/Function

Directions & Suggested Use

Suggested/Recommended/Usage/Directions

Directions: For adults, we recommend taking two (2) tablets three times daily, preferably on an empty stomach. In order to obtain maximum benefits, SAM-e should be taken at least 30 minutes prior to a meal or follow the advice of your health care professional.

Warnings & Precautions

Precautions re: Pregnant or Nursing or Prescription Medications

WARNING: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Precautions re: All Other

Discontinue use and consult your doctor if any adverse reactions occur.

Precautions re: All Other

TAMPER RESISTANT: Do not use if blister seal is cut, torn or open.

Precautions re: Children

KEEP OUT OF REACH OF CHILDREN.

Storage

Storage

Store at room temperature and avoid excessive heat.

Formulation

Formulation re: Does NOT Contain

FREE OF: artificial flavor, preservatives, sugar, milk, lactose, soy, gluten, wheat, yeast, fish.

FDA Statements

FDA Disclaimer Statement

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Other Label Statements

General Statements: All Other Content

Supports Mood and Emotional Well-being

Brand IP Statement(s) re: (c), (TM), (SM)

(C)PhysioLogics, 2011

General Statements: All Other Content

A NOTE ABOUT OUR ENTERIC COATING: The enteric coating helps the breakdown of SAM-e occur in the small intestine.* In addition, the enteric coating is designed to protect SAM-e from moisture and serve as a protective barrier so that SAM-e can be absorbed where it can provide you with its benefits.*

General Statements: All Other Content

Part No. 22-71165

General Statements: All Other Content

PRODUCT BENEFITS: SAM-e is involved in over 35 biochemical reactions involving enzymatic transmethylation.* The methylation process is the mechanism by which the body rids itself of potentially damaging compounds, synthesizes neurotransmitters, regulates enzyme activity within the cell and maintains the flexibility of cell membranes.* Sam-e supports mood and emotional well-being.*

General Statements: All Other Content

Laboratory Tested to Guarantee Quality

General Statements: All Other Content

For Health Care Professional Use Only

General: Product/Version Code

PROD. NO. 7116 B36221 04D

General Statements: All Other Content

As a reminder, discuss the supplements and medications you take with your health care providers.

Manufacturer & Distributor

Other

Other

1-800-765-6775

Manufacturer

PhysioLogics, LLC

2100 Smithtown Avenue, Ronkonkoma, NY, 11779, U.S.A.

Market Reference

$10.00 – $101.03· 40 listings
  • Pure Encapsulations SAMe 60 Capsules

    Pure For You4.4(70)
    $84.50
  • NOW Foods SAMe 200 mg 60 Capsules

    Walmart - DailyVita4.7(447)
    $23.41
  • Jarrow Formulas SAM-e 200 mg Tablets

    iHerb4.6(444)
    $18.34
  • Doctor's Best SAM-e 200 mg Enteric Coated Tablets

    Target4.7(665)
    $36.99
  • SuperSmart SAM-e 200mg

    supersmart.com4.6(65)
    $50.23
  • Protocol For Life Balance SAMe 200 mg 60 Capsules

    Walmart - Pattern4.9(75)
    $40.00
  • Source Naturals SAMe 200 mg Tablets

    Vitacost.com4.7(136)
    $46.89
  • NOW Foods SAMe 200 mg 60 Veg Capsules

    NOW
    $74.99

Where to Buy Locally

Enter your city or ZIP code to find supplement & health stores in your area that may carry this product.

Research & Studies

  • S-Adenosylmethionine (SAMe) for Central Nervous System Health: A Systematic Review

    KER Baden, H McClain, E Craig, N Gibson, JA Draime… - Nutrients, 2024 - mdpi.com

    … depressive symptoms were seen ranging from 200 mg to 3200 mg. Many studies started at … doses starting at 200 mg to 800 mg for mild–moderate depression and 800 mg daily in one to …

    202410 citations
  • Safety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis

    KL Soeken, WL Lee, RB Bausell, M Agelli… - J Fam Pract, 2002 - cdn.mdedge.com

    … ring sulphur-containing physiologic compound synthesized … as a dietary supplement to promote joint health, mobility, and … ,” “Sammy,” and “SAM-e.” Results were then combined into the …

    2002175 citations
  • S-adenosylmethionine (SAMe) as treatment for depression: a systematic review

    A Williams, C Girard, D Jui, A Sabina… - Clinical and …, 2005 - search.proquest.com

    … used to pair more than 200 medical conditions with CAM … 200 mg oral SAMe twice daily and increased to 1600 mg by … received 200 mg oral SAMe twice daily and increased to 1600 mg …

    2005146 citations
  • S-adenosylmethionine

    T Bottiglieri, PL Gerbarg, RP Brown - … and Integrative Treatments …, 2017 - books.google.com

    … biochemistry at the National Institute of Mental Health. An amino acid–derived metabolite… mg/day as tolerated. Elderly, debilitated, or medication-sensitive patients should start at 200 mg…

    20179 citations
  • Complementary and Alternative Medicine in Pharmacology

    L Dehner - Pharmacology for Rehabilitation Professionals-E …, 2010 - books.google.com

    … (CS), and S-adenosylmethionine (SAM-e) for the pain and … liver, has varied physiologic functions, including stimulation … 1.2 g (600 mg 2 day) of SAM-e or 200 mg (100 mg 2 day) of …

    2010
  • S-Adenosyl-L-methionine for major depressive disorder

    D De Berardis, L Orsolini, F Iasevoli… - Melatonin …, 2016 - Springer

    … SAMe is an important physiologic compound, widely distributed throughout the body tissues and … The dose range is typically 100–200 mg/day (or 200–400 mg/day) IM or 800–1,200 mg/…

    20163 citations

Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2014-01-24. DSLD Label ID: 29146. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.