Brand: PhysioLogics

Tablet or PillOff Market
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Net Contents

30 Enteric Coated Tablet(s)

Serving Size

1 Tablet(s)

Servings Per Container

Not specified

Supplement Form

Tablet or Pill

Bar Code (UPC/SKU)

7 16963 50260 3

Product Version

Not specified

Suggested Use

Directions: For adults; take one (1) tablet three times daily; preferably on an empty stomach. In order to obtain maximum benefits; SAM-e should be taken at least 30 minutes prior to a meal or follow the advice of your health care professional.

Market Reference

$7.58 – $112.99· 40 listings
  • Nature Made SAM-e Complete 400 mg

    CVS Pharmacy4.6(190)
    $64.99
  • (3 pack) Spring Valley SAMe Dietary Supplement Value Pack, 400 mg, 40 Count

    Walmart4.6(186)
    $74.88
  • Walgreens Sam-e 400 mg Coated Caplets

    Walgreens.com
    $49.99
  • Jarrow Formulas SAM-e 400 60 Tablets

    Life Extension4.7(430)
    $38.99
  • Doctor's Best SAMe 400 mg Double Strength Enteric Coated Tablets

    Target4.7(771)
    $52.99
  • BrainMD SAMe Mood & Movement 400 30 Tablets

    BrainMD by Dr Amen4.4(121)
    $44.96
  • 2 Pack-sam-e 400 Mg Vegan, Kosher, Non-gmo, Soy-, Gluten-,

    eBay4.3(32)
    $73.55
  • Swanson 400 mg SAMe 30 Tablets

    Swanson Health Products4.6(394)
    $25.69

Where to Buy Locally

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Research & Studies

  • S-Adenosylmethionine (SAMe) for Central Nervous System Health: A Systematic Review

    KER Baden, H McClain, E Craig, N Gibson, JA Draime… - Nutrients, 2024 - mdpi.com

    … 400 mg once or twice daily, 400 mg daily titrated to 800 mg twice daily for ADHD, and 400 mg daily titrated to 800 mg … For depression, SAMe was dosed between 200 and 3200 mg daily, …

    202410 citations
  • … of a novel oral formulation of S-adenosylmethionine (MSI-195) in healthy subjects: dose escalation, food effect and comparison to a commercial nutritional supplement …

    BR Cameron, L Ferreira, ID MacDonald - BMC Pharmacology and …, 2020 - Springer

    … MSI discovered that formulations of SAM-e including propyl gallate have enhanced … has a dosage strength of 400 mg (based on the weight of the free base). The SAM-e counter-ions are …

    202014 citations
  • Safety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis

    KL Soeken, WL Lee, RB Bausell, M Agelli… - J Fam Pract, 2002 - cdn.mdedge.com

    … ring sulphur-containing physiologic compound synthesized … as a dietary supplement to promote joint health, mobility, and … ,” “Sammy,” and “SAM-e.” Results were then combined into the …

    2002174 citations
  • A comprehensive review on the efficacy of S-Adenosyl-L-methionine in Major Depressive Disorder.

    D De Berardis, L Orsolini, N Serroni… - CNS & Neurological …, 2016 - ingentaconnect.com

    … Data Synthesis: SAMe is an important physiologic compound, … after supplementation of 800-1600 mg/d of oral SAMe. … Sadenosylmethionine (SAM-e) for the treatment of depression in …

    201695 citations
  • Rapid review of breast cancer treatment side effects and dietary supplement/integrative options from A to Z: what helps, harms, or does nothing?

    MA Moyad - Integrative Medicine for Breast Cancer: An Evidence …, 2016 - Springer

    … physiologic locations where it can help to ameliorate pain. … SAM-e in my experience is prohibitive cost because SAM-e … sexual health should also be investigated from SAM-e depression …

    20166 citations
  • Evidence for S-adenosyl-L-methionine (SAM-e) for the treatment of major depressive disorder.

    GI Papakostas - Journal of Clinical Psychiatry, 2009 - psychiatrist.com

    … increasingly interested in nonpharmaceutical supplements for treating depression. One of the best-studied of these supplements is S-adenosyl-l-methionine (SAM-e), a naturally …

    2009178 citations

Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2014-01-24. DSLD Label ID: 29147. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.