SAM-e 400 mg®
Non-Nutrient / Non-BotanicalBrand: PhysioLogics
Net Contents
30 Enteric Coated Tablet(s)
Serving Size
1 Tablet(s)
Servings Per Container
Not specified
Supplement Form
Tablet or Pill
Bar Code (UPC/SKU)
7 16963 50260 3
Product Version
PROD. NO. 50260 B36222 02B
Label Analysis
Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.
Single-ingredient formula listed in Supplement Facts.
Every active ingredient discloses a specific amount per serving.
Label states: Gluten-Free.
This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.
Supplement Facts
Serving Size: 1 Tablet(s) · 3 per day
| Ingredient | Amount Per Serving | |
|---|---|---|
| S-Adenosylmethionine | 400 mg | — |
Not Present
Other Ingredients
Target Groups
Label Claims
Directions & Suggested Use
Suggested/Recommended/Usage/Directions
Directions: For adults, take one (1) tablet three times daily, preferably on an empty stomach. In order to obtain maximum benefits, SAM-e should be taken at least 30 minutes prior to a meal or follow the advice of your health care professional.
Warnings & Precautions
Precautions re: Pregnant or Nursing or Prescription Medications
WARNING: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.
Precautions re: All Other
Discontinue use and consult your doctor if any adverse reactions occur.
Precautions re: All Other
TAMPER RESISTANT: Do not use if blister seal is cut, torn or open.
Precautions re: Children
KEEP OUT OF REACH OF CHILDREN.
Storage
Storage
Store at room temperature and avoid excessive heat.
Formulation
Formulation re: Does NOT Contain
FREE OF: artificial flavor, preservatives, sugar, milk, lactose, soy, gluten, wheat, yeast, fish.
FDA Statements
FDA Disclaimer Statement
*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Other Label Statements
General Statements: All Other Content
As a reminder, discuss the supplements and medications you take with your health care providers.
General Statements: All Other Content
PRODUCT BENEFITS: SAM-e is involved in over 35 biochemical reactions involving enzymatic transmethylation.* The methylation process is the mechanism by which the body rids itself of potentially damaging compounds, synthesizes neurotransmitters, regulates enzyme activity within the cell and maintains the flexibility of cell membranes.* Sam-e can support mood and emotional well-being.*
General Statements: All Other Content
A NOTE ABOUT OUR ENTERIC COATING: The enteric coating helps the breakdown of SAM-e occur in the small intestine.* In addition, the enteric coating is designed to protect SAM-e from moisture and serve as a protective barrier so that SAM-e can be absorbed where it can provide you with the greatest benefits.*
General Statements: All Other Content
Part No. 22-50260
General Statements: All Other Content
Double Strength - Supports Mood and Emotional Well-being - Healthy liver function - Healthy joint function
General Statements: All Other Content
Laboratory Tested to Guarantee Quality
General Statements: All Other Content
For Health Care Professional Use Only
Brand IP Statement(s) re: (c), (TM), (SM)
(C)PhysioLogics, 2011
General: Product/Version Code
PROD. NO. 50260 B36222 02B
Manufacturer & Distributor
Distributor
PhysioLogics, LLC
2100 Smithtown Ave, Ronkonkoma, NY, 11779, U.S.A.
Other
Other
1-800-765-6775
Market Reference
Nature Made SAM-e Complete 400 mg
CVS Pharmacy4.6(190)$64.99
(3 pack) Spring Valley SAMe Dietary Supplement Value Pack, 400 mg, 40 Count
Walmart4.6(186)$74.88
Walgreens Sam-e 400 mg Coated Caplets
Walgreens.com$49.99
Jarrow Formulas SAM-e 400 60 Tablets
Life Extension4.7(430)$38.99
Doctor's Best SAMe 400 mg Double Strength Enteric Coated Tablets
Target4.7(771)$52.99
BrainMD SAMe Mood & Movement 400 30 Tablets
BrainMD by Dr Amen4.4(121)$44.96
2 Pack-sam-e 400 Mg Vegan, Kosher, Non-gmo, Soy-, Gluten-,
eBay4.3(32)$73.55
Swanson 400 mg SAMe 30 Tablets
Swanson Health Products4.6(394)$25.69
Where to Buy Locally
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The Vitamin Shoppe
4.4 (119)Vitamin & supplements store
2021 Gunbarrel Rd, Chattanooga, TN 37421
GNC
3.2 (42)Vitamin & supplements store
2100 Hamilton Pl Blvd #252, Chattanooga, TN 37421
Nature's Finest Nutrition
4.7 (85)Vitamin & supplements store
7232 Lee Hwy, Chattanooga, TN 37421
Nutrition World
5.0 (1737)Health food store
6201 Lee Hwy, Chattanooga, TN 37421
STACK'd Supplements
5.0 (133)Vitamin & supplements store
5724 TN-153 b, Hixson, TN 37343
Nutrition Shoppe
5.0 (18)Vitamin & supplements store
112 Herron St, Fort Oglethorpe, GA 30742
NutritionFaktory.com
4.5 (39)Vitamin & supplements store
6053 Artesian Cir, Ooltewah, TN 37363
The Vitamin Shoppe
4.7 (80)Vitamin & supplements store
5546 TN-153 #114, Hixson, TN 37343
Research & Studies
S-Adenosylmethionine (SAMe) for Central Nervous System Health: A Systematic Review
KER Baden, H McClain, E Craig, N Gibson, JA Draime… - Nutrients, 2024 - mdpi.com
… 400 mg once or twice daily, 400 mg daily titrated to 800 mg twice daily for ADHD, and 400 mg daily titrated to 800 mg … For depression, SAMe was dosed between 200 and 3200 mg daily, …
202410 citations… of a novel oral formulation of S-adenosylmethionine (MSI-195) in healthy subjects: dose escalation, food effect and comparison to a commercial nutritional supplement …
BR Cameron, L Ferreira, ID MacDonald - BMC Pharmacology and …, 2020 - Springer
… MSI discovered that formulations of SAM-e including propyl gallate have enhanced … has a dosage strength of 400 mg (based on the weight of the free base). The SAM-e counter-ions are …
202014 citationsSafety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis
KL Soeken, WL Lee, RB Bausell, M Agelli… - J Fam Pract, 2002 - cdn.mdedge.com
… ring sulphur-containing physiologic compound synthesized … as a dietary supplement to promote joint health, mobility, and … ,” “Sammy,” and “SAM-e.” Results were then combined into the …
2002174 citationsA comprehensive review on the efficacy of S-Adenosyl-L-methionine in Major Depressive Disorder.
D De Berardis, L Orsolini, N Serroni… - CNS & Neurological …, 2016 - ingentaconnect.com
… Data Synthesis: SAMe is an important physiologic compound, … after supplementation of 800-1600 mg/d of oral SAMe. … Sadenosylmethionine (SAM-e) for the treatment of depression in …
201695 citationsRapid review of breast cancer treatment side effects and dietary supplement/integrative options from A to Z: what helps, harms, or does nothing?
MA Moyad - Integrative Medicine for Breast Cancer: An Evidence …, 2016 - Springer
… physiologic locations where it can help to ameliorate pain. … SAM-e in my experience is prohibitive cost because SAM-e … sexual health should also be investigated from SAM-e depression …
20166 citationsEvidence for S-adenosyl-L-methionine (SAM-e) for the treatment of major depressive disorder.
GI Papakostas - Journal of Clinical Psychiatry, 2009 - psychiatrist.com
… increasingly interested in nonpharmaceutical supplements for treating depression. One of the best-studied of these supplements is S-adenosyl-l-methionine (SAM-e), a naturally …
2009178 citations
Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2014-01-24. DSLD Label ID: 29147. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.
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