SAMe 400 mg®
Non-Nutrient / Non-BotanicalBrand: NOW
Net Contents
60 Tablet(s)
Serving Size
1 Tablet(s)
Servings Per Container
Not specified
Supplement Form
Tablet or Pill
Bar Code (UPC/SKU)
7 33739 00141 2
Product Version
CODE 0141B V5
Label Analysis
Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.
Single-ingredient formula listed in Supplement Facts.
Every active ingredient discloses a specific amount per serving.
Label states: Vegan, Vegetarian, Gluten-Free.
This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.
Supplement Facts
Serving Size: 1 Tablet(s) · 2–4 per day
| Ingredient | Amount Per Serving | |
|---|---|---|
| SAMe(S-Adenosyl-L-Methionine Disulfate Tosylate) | 400 mg | — |
Not Present
Other Ingredients
Target Groups
Label Claims
Directions & Suggested Use
Suggested/Recommended/Usage/Directions
Suggested Usage: Take 1 tablet 2 to 4 times daily, preferably on an empty stomach.
Warnings & Precautions
Precautions re: All Other
SAMe (S-adenosylmethionine), a compound native to the body, is a component of many biochemical reactions, including those that affect brain biochemistry and joint health.* Numerous studies have indicated that SAMe can help to alleviate transient minor aches and pains resulting from overexertion or strain.* In addition, because SAMe is also necessary for the synthesis of neurotransmitters, it plays an important role in mood support.*
Precautions re: All Other
Caution: For adults only.
Precautions re: Pregnant or Nursing or Prescription Medications
Individuals with bipolar depression, anxiety disorders or taking antidepressant medications should not take SAMe unless under professional medical supervision. Consult physician if pregnant/nursing, taking medication, or have a medical condition.
Precautions re: Children
Keep out of reach of children.
Precautions re: Allergies
Not manufactured with wheat, gluten, soy, milk, egg, fish or shellfish ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.
Precautions re: All Other
Do Not Eat Freshness Packets. Keep in Bottle.
Storage
Storage
Refrigeration recommended after opening.
Formulation
Formulation re: Vegetarian/Vegan
Vegetarian/Vegan
Formulation re: Does NOT Contain
Not manufactured with wheat, gluten, soy, milk, egg, fish or shellfish ingredients.
FDA Statements
FDA Disclaimer Statement
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
FDA Statement of Identity
A Dietary Supplement
Other Label Statements
Brand IP Statement(s) re: (c), (TM), (SM)
NOW SAMe is enteric-coated, which makes it very well tolerated and protects it from degradation.
General: Product/Version Code
CODE 0141B V5
General Statements: All Other Content
Nervous System Support*
General Statements: All Other Content
~ Supports Emotional Well-Being* ~ Supports Joint Health*
General Statements: All Other Content
ENTERIC COATED
General Statements: All Other Content
Amino Acids
General Statements: All Other Content
Family owned since 1968.
General Statements: All Other Content
Natural color variation may occur in this product. Please Recycle.
Seals/Symbols
GMP QUALITY ASSURED
Manufacturer & Distributor
Manufacturer
NOW Foods
395 S. Glen Ellyn Rd., Bloomingdale, IL, 60108, USA
Market Reference
NOW Foods SAMe 400 mg 30 Tablets
Vitacost.com4.7(414)$28.16NOW SAMe 400mg Tablets
Village Vitamin Store4.0(4)$36.76(2 pack) NOW Foods SAMe Nervous System Support, 400mg, 30 Ct, Size: 3.45
Walmart - Fruitful Yield4.7(414)$50.51NOW Vitamin E Mixed 400 IU 100 Softgels
NOW4.8(317)$19.99Now Foods E-400 Softgels
Vitacost.com4.7(447)$15.91NOW Foods Sun-E 400 Softgels
Swanson Health Products4.8(322)$15.66Now SAM-E 400MG 60 tablets
William's Natural Foods4.7(414)$71.99Now Foods Dry E-400 Capsules
Vitacost.com4.8(728)$17.13
Where to Buy Locally
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Athletic Nutrition Angers
4.9 (163)Vitamin & supplements store
2 Av. du Général Patton, 49000 Angers
Fitness Shop
Vitamin & supplements store
58 Rue Plantagenêt, 49100 Angers
Research & Studies
… of a novel oral formulation of S-adenosylmethionine (MSI-195) in healthy subjects: dose escalation, food effect and comparison to a commercial nutritional supplement …
BR Cameron, L Ferreira, ID MacDonald - BMC Pharmacology and …, 2020 - Springer
… The test article used in the present study has a dosage strength of 400 mg (based on the weight of the free base). The SAM-e counter-ions are disulfate tosylate and the overall tablet …
202014 citationsSafety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis
KL Soeken, WL Lee, RB Bausell, M Agelli… - J Fam Pract, 2002 - cdn.mdedge.com
… (SAMe), a dietary supplement now available in the United … 1999 as a dietary supplement to promote joint health, mobility, … 600 mg per day orally17,21,25; and one used 400 mg per …
2002175 citationsS-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial.[ISRCTN36233495]
WI Najm, S Reinsch, F Hoehler, JS Tobis… - BMC musculoskeletal …, 2004 - Springer
… S-Adenosylmethionine (SAMe) is a dietary supplement used … On most functional health measures both groups showed a … An ANOVA on pain-today scores in SAMe treated subjects with …
2004213 citationsA role for supplements in optimizing health: the metabolic tune-up
BN Ames - Archives of biochemistry and biophysics, 2004 - Elsevier
An optimum intake of micronutrients and metabolites, which varies with age and genetic constitution, would tune up metabolism and give a marked increase in health, particularly for the …
2004190 citationsA decade of nutraceutical patents: where are we now in 2018?
P Daliu, A Santini, E Novellino - Expert opinion on therapeutic …, 2018 - Taylor & Francis
… of a food that has medical or health benefits, including the … be considered in the same way as for any food supplement or … in the range between 400 mg/day and 700 mg/day. Again in …
2018165 citationsThe supplement handbook: a trusted expert's guide to what works & what's worthless for more than 100 conditions
M Moyad, J Lee - 2014 - books.google.com
… Now, more than 20 years later, I have the same position, but the endowment has grown substantially … I think the time has arrived for supplements to be included in these everyday health …
201417 citations
Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2015-12-23. DSLD Label ID: 55108. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.
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