Brand: NOW

Tablet or PillNon-Nutrient/Non-BotanicalOff Market
Click to view full label

Net Contents

30 Tablet(s)

Serving Size

1 Tablet(s)

Servings Per Container

Not specified

Supplement Form

Tablet or Pill

Bar Code (UPC/SKU)

7 33739 00139 9

Product Version

CODE 0139B V5

Label Analysis

Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.

1Active Ingredients

Single-ingredient formula listed in Supplement Facts.

100%Amount Transparency

Every active ingredient discloses a specific amount per serving.

3Dietary Attributes

Label states: Vegan, Vegetarian, Gluten-Free.

This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.

Supplement Facts

Serving Size: 1 Tablet(s) · 2–4 per day

IngredientAmount Per Serving
SAMe(S-Adenosyl-L-Methionine Disulfate Tosylate)400 mg

Not Present

Other Ingredients

CelluloseCroscarmellose SodiumMagnesium StearateSilicaStearic AcidAscorbic AcidCitric AcidEnteric Coating

Target Groups

VeganVegetarianAdult (18 - 50 Years)Gluten FreeDairy Free

Label Claims

All OtherStructure/Function

Directions & Suggested Use

Suggested/Recommended/Usage/Directions

Suggested Usage: Take 1 tablet 2 to 4 times daily, preferably on an empty stomach.

Warnings & Precautions

Precautions re: All Other

SAMe (S-adenosylmethionine), a compound native to the body, is a component of many biochemical reactions, including those that affect brain biochemistry and joint health.* Numerous studies have indicated that SAMe can help to alleviate transient minor aches and pains resulting from overexertion or strain.* In addition, because SAMe is also necessary for the synthesis of neurotransmitters, it plays an important role in mood support.*

Precautions re: All Other

Caution: For adults only.

Precautions re: Pregnant or Nursing or Prescription Medications

Individuals with bipolar depression, anxiety disorders or taking antidepressant medications should not take SAMe unless under professional medical supervision. Consult physician if pregnant/nursing, taking medication, or have a medical condition.

Precautions re: Children

Keep out of reach of children.

Precautions re: Allergies

Not manufactured with wheat, gluten, soy, milk, egg, fish or shellfish ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Precautions re: All Other

Do Not Eat Freshness Packets. Keep in Bottle.

Storage

Storage

Refrigeration recommended after opening.

Formulation

Formulation re: Vegetarian/Vegan

Vegetarian/Vegan

Formulation re: Does NOT Contain

Not manufactured with wheat, gluten, soy, milk, egg, fish or shellfish ingredients.

FDA Statements

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

A Dietary Supplement

Other Label Statements

Seals/Symbols

GMP QUALITY ASSURED

Brand IP Statement(s) re: (c), (TM), (SM)

NOW SAMe is enteric-coated, which makes it very well tolerated and protects it from degradation.

General: Product/Version Code

CODE 0139B V5

General Statements: All Other Content

Nervous System Support*

General Statements: All Other Content

~ Supports Emotional Well-Being* ~ Supports Joint Health*

General Statements: All Other Content

ENTERIC COATED

General Statements: All Other Content

Amino Acids

General Statements: All Other Content

Family owned since 1968.

General Statements: All Other Content

Natural color variation may occur in this product. Please Recycle.

Manufacturer & Distributor

Manufacturer

NOW Foods

395 S. Glen Ellyn Rd., Bloomingdale, IL, 60108, USA

Market Reference

$3.00 – $124.99· 40 listings
  • NOW Foods SAMe 400 mg 30 Tablets

    iHerb4.7(414)
    $28.16
  • NOW SAMe 400mg Tablets

    Village Vitamin Store4.0(4)
    $36.77
  • Now Foods E-400 Softgels

    Vitacost.com4.7(447)
    $15.91
  • (2 pack) NOW Foods SAMe Nervous System Support, 400mg, 30 Ct, Size: 3.45

    Walmart - Fruitful Yield4.7(414)
    $50.51
  • NOW Foods Sun-E 400 Softgels

    Swanson Health Products4.8(322)
    $15.66
  • Now SAM-E 400MG 60 tablets

    William's Natural Foods4.7(414)
    $71.99
  • Now Foods E-400 D-Alpha Tocopheryl 250 Softgels

    Target4.8(10000)
    $30.99
  • Nature Made SAM-e Complete 400 mg

    Walmart4.5(310)
    $53.98

Where to Buy Locally

Enter your city or ZIP code to find supplement & health stores in your area that may carry this product.

Showing representative supplement & health retailers — search above for stores in your area.

  • Active Nutrition

    5.0 (21)

    Vitamin & Supplements Shop

    2168 Coventry Rd, Sheldon, Birmingham B26 3JB

  • Master of Nutrition

    4.6 (112)

    Vitamin & Supplements Shop

    110 Bordesley Grn, Birmingham B9 4TS

  • Starplus Vitamins Ltd

    3.5 (2)

    Vitamin & Supplements Shop

    Kings Rd, Tyseley, Birmingham B11 2AL

  • Bodyshocker Sports Supplement Warehouse

    4.9 (26)

    Sports Nutrition Shop

    Monkspath Business Park, Highlands Rd, Shirley, Solihull B90 4NZ

  • PHILOSOFIT SPORTS & NUTRITION

    5.0 (51)

    Sports Nutrition Shop

    891b Washwood Heath Rd, Ward End, Birmingham B8 2NA

  • Midland Fitness and Nutrition ( Midland Supplements)

    4.8 (23)

    Health food shop

    818 Bristol Rd S, Northfield, Birmingham B31 2NS

  • Body Mania

    4.7 (179)

    Vitamin & Supplements Shop

    328 Slade Rd, Birmingham B23 7LP

  • Dietary Supplements Store

    Vitamin & Supplements Shop

    14 Cannon St, Birmingham B2 5EP

Research & Studies

  • … of a novel oral formulation of S-adenosylmethionine (MSI-195) in healthy subjects: dose escalation, food effect and comparison to a commercial nutritional supplement …

    BR Cameron, L Ferreira, ID MacDonald - BMC Pharmacology and …, 2020 - Springer

    … The test article used in the present study has a dosage strength of 400 mg (based on the weight of the free base). The SAM-e counter-ions are disulfate tosylate and the overall tablet …

    202014 citations
  • Safety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis

    KL Soeken, WL Lee, RB Bausell, M Agelli… - J Fam Pract, 2002 - cdn.mdedge.com

    … (SAMe), a dietary supplement now available in the United … 1999 as a dietary supplement to promote joint health, mobility, … 600 mg per day orally17,21,25; and one used 400 mg per …

    2002175 citations
  • S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial.[ISRCTN36233495]

    WI Najm, S Reinsch, F Hoehler, JS Tobis… - BMC musculoskeletal …, 2004 - Springer

    … S-Adenosylmethionine (SAMe) is a dietary supplement used … On most functional health measures both groups showed a … An ANOVA on pain-today scores in SAMe treated subjects with …

    2004213 citations
  • A role for supplements in optimizing health: the metabolic tune-up

    BN Ames - Archives of biochemistry and biophysics, 2004 - Elsevier

    An optimum intake of micronutrients and metabolites, which varies with age and genetic constitution, would tune up metabolism and give a marked increase in health, particularly for the …

    2004190 citations
  • A decade of nutraceutical patents: where are we now in 2018?

    P Daliu, A Santini, E Novellino - Expert opinion on therapeutic …, 2018 - Taylor & Francis

    … of a food that has medical or health benefits, including the … be considered in the same way as for any food supplement or … in the range between 400 mg/day and 700 mg/day. Again in …

    2018165 citations
  • The supplement handbook: a trusted expert's guide to what works & what's worthless for more than 100 conditions

    M Moyad, J Lee - 2014 - books.google.com

    … Now, more than 20 years later, I have the same position, but the endowment has grown substantially … I think the time has arrived for supplements to be included in these everyday health …

    201417 citations

Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2015-12-23. DSLD Label ID: 55107. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.