SAMe 400 mg®

Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.

This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.

Serving Size: 1 Tablet(s) · 2–4 per day

Not Present

• 

  NOW Foods SAMe 400 mg 60 Tablets

  Fruitful Yield4.7(417)

  $45.99
• 

  NOW SAMe 400mg Tablets

  Village Vitamin Store4.7(417)

  $36.56
• 

  (2 pack) NOW Foods SAMe Nervous System Support, 400mg, 30 Ct, Size: 3.45

  Walmart - Fruitful Yield4.7(417)

  $50.52
• 

  NOW Softgels with Vitamin E-400

  NOW4.8(12000)

  $25.99
• 

  NOW Foods Sun-E 400 Softgels

  iHerb4.8(327)

  $16.52
• 

  NOW Foods Vitamin E-400 With Mixed Tocopherols

  NOW4.8(12000)

  $19.99
• 

  Nature Made SAM-e Complete 400 mg

  Walmart4.6(190)

  $52.97
• 

  Now Foods E-400 Softgels

  Swanson Health Products4.8(12000)

  $30.49

Enter your city or ZIP code to find supplement & health stores in your area that may carry this product.

Showing representative supplement & health retailers — search above for stores in your area.

• The Vitamin Shoppe

  4.6 (171)

  Vitamin & supplements store

  780 Truse Pkwy, Memphis, TN 38117

  Directions(901) 682-0334

• GNC

  4.1 (54)

  Vitamin & supplements store

  3619 Riverdale Rd Ste 101, Memphis, TN 38115

  Directions(901) 546-0561

• The Vitamin Shoppe

  4.6 (99)

  Vitamin & supplements store

  7670 Winchester Rd #103, Memphis, TN 38125

  Directions(901) 309-3470

• GNC

  4.5 (59)

  Vitamin & supplements store

  3452 Poplar Ave, Memphis, TN 38111

  Directions(901) 324-7700

• The Vitamin Shoppe

  4.6 (159)

  Vitamin & supplements store

  2286 N Germantown Parkyway Ste 102, Cordova, TN 38016

  Directions(901) 384-4909

• GNC

  4.5 (21)

  Vitamin & supplements store

  5985 Stage Rd Ste 28, Bartlett, TN 38134

  Directions(901) 382-8999

• GNC

  4.7 (51)

  Vitamin & supplements store

  7447 Goodman Rd, Olive Branch, MS 38654

  Directions(662) 893-3871

• GNC

  3.7 (21)

  Vitamin & supplements store

  9155 US-72 SPACE #11, Germantown, TN 38138

  Directions(901) 755-4745

• … of a novel oral formulation of S-adenosylmethionine (MSI-195) in healthy subjects: dose escalation, food effect and comparison to a commercial nutritional supplement …

  BR Cameron, L Ferreira, ID MacDonald - BMC Pharmacology and …, 2020 - Springer

  … The test article used in the present study has a dosage strength of 400 mg (based on the weight of the free base). The SAM-e counter-ions are disulfate tosylate and the overall tablet …

  202014 citations

• Safety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis

  KL Soeken, WL Lee, RB Bausell, M Agelli… - J Fam Pract, 2002 - cdn.mdedge.com

  … (SAMe), a dietary supplement now available in the United … 1999 as a dietary supplement to promote joint health, mobility, … 600 mg per day orally17,21,25; and one used 400 mg per …

  2002174 citations

• S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial.[ISRCTN36233495]

  WI Najm, S Reinsch, F Hoehler, JS Tobis… - BMC musculoskeletal …, 2004 - Springer

  … S-Adenosylmethionine (SAMe) is a dietary supplement used … On most functional health measures both groups showed a … An ANOVA on pain-today scores in SAMe treated subjects with …

  2004213 citations

• A role for supplements in optimizing health: the metabolic tune-up

  BN Ames - Archives of biochemistry and biophysics, 2004 - Elsevier

  An optimum intake of micronutrients and metabolites, which varies with age and genetic constitution, would tune up metabolism and give a marked increase in health, particularly for the …

  2004189 citations

• A decade of nutraceutical patents: where are we now in 2018?

  P Daliu, A Santini, E Novellino - Expert opinion on therapeutic …, 2018 - Taylor & Francis

  … of a food that has medical or health benefits, including the … be considered in the same way as for any food supplement or … in the range between 400 mg/day and 700 mg/day. Again in …

  2018164 citations

• The supplement handbook: a trusted expert's guide to what works & what's worthless for more than 100 conditions

  M Moyad, J Lee - 2014 - books.google.com

  … Now, more than 20 years later, I have the same position, but the endowment has grown substantially … I think the time has arrived for supplements to be included in these everyday health …

  201417 citations

Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2025-07-24. DSLD Label ID: 335305. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.