SAMe 400 mg®
Non-Nutrient / Non-BotanicalBrand: NOW
Net Contents
60 Tablet(s)
Serving Size
1 Tablet(s)
Servings Per Container
60
Supplement Form
Tablet or Pill
Bar Code (UPC/SKU)
7 33739 00141 2
Product Version
CODE 0141D V9
Label Analysis
Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.
Single-ingredient formula listed in Supplement Facts.
Every active ingredient discloses a specific amount per serving.
Label states: Gluten-Free, Kosher.
This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.
Supplement Facts
Serving Size: 1 Tablet(s) · 2–4 per day
| Ingredient | Amount Per Serving | |
|---|---|---|
| SAMe(S-Adenosyl-L-Methionine Disulfate Tosylate) | 400 mg | — |
Not Present
Other Ingredients
Target Groups
Label Claims
Directions & Suggested Use
Suggested/Recommended/Usage/Directions
Suggested Usage: Take 1 tablet 2 to 4 times daily, preferably on an empty stomach.
Warnings & Precautions
Precautions re: Children
Caution: For adults only.
Precautions re: Pregnant or Nursing or Prescription Medications
Individuals with bipolar, depression, anxiety disorders or taking antidepressant medications should not take SAMe unless under professional medical supervision. Consult physician if pregnant/nursing, taking medication, or have a medical condition.
Precautions re: Children
Keep out of reach of children.
Precautions re: Allergies
Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or sesame ingredients. Produced in a GMP facility that produces other ingredients containing these allergens.
Storage
Storage
Store in a cool, dry place after opening.
Formulation
Formula re: Contains
SAMe (S-adenoslymethionine), a compound native to the body, is a component of many biochemical reactions, including those that affect brain biochemistry and joint health. Numerous studies have indicated that SAMe can help to alleviate transient minor aches and pains resulting from overexertion or strain. In addition, because SAMe is also necessary for the synthesis of neurotransmitters, it plays an important role in mood support.
Formulation re: Other
Nervous system support No enteric coating needed Supports joint health
Formula re: Kosher
Triangle K (Kosher)
Formulation re: Other
Made and quality tested in the USA with globally sourced ingredients.
Formulation re: Does NOT Contain
Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or sesame ingredients.
Formulation re: Other
Natural color variation may occur with this product.
FDA Statements
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
FDA Statement of Identity
A Dietary Supplement
Other Label Statements
Seals/Symbols
Triangle K (Kosher)
General Statements: All Other Content
Amino acids Family owned since 1968.
Seals/Symbols
GMP Quality Assured
Manufacturer & Distributor
Distributor
NOW FOODS
395 S. Glen Ellyn Rd., Bloomingdale, IL, 60108, USA
Market Reference
NOW Foods SAMe 400 mg 60 Tablets
Fruitful Yield4.7(417)$45.99NOW SAMe 400mg Tablets
Village Vitamin Store4.7(417)$36.56(2 pack) NOW Foods SAMe Nervous System Support, 400mg, 30 Ct, Size: 3.45
Walmart - Fruitful Yield4.7(417)$50.52NOW Softgels with Vitamin E-400
NOW4.8(12000)$25.99NOW Foods Vitamin E-400 With Mixed Tocopherols
NOW4.8(12000)$19.99Magnesium 400mg 180 Caps
H-E-B4.8(9800)$13.63NOW Foods Sun-E 400 Softgels
iHerb4.8(327)$16.52Nature Made SAM-e Complete 400 mg
Walmart4.6(190)$52.97
Where to Buy Locally
Enter your city or ZIP code to find supplement & health stores in your area that may carry this product.
Showing representative supplement & health retailers — search above for stores in your area.
GNC
4.4 (28)Vitamin & supplements store
156 Town Center Pkwy, Slidell, LA 70458
The Vitamin Shoppe
4.7 (104)Vitamin & supplements store
179 Northshore Blvd #7, Slidell, LA 70460
Walgreens
2.9 (203)Drug store
1260 Front St, Slidell, LA 70458
GNC
4.5 (19)Vitamin & supplements store
1573 Gause Blvd, Slidell, LA 70458
Walgreens
2.6 (104)Drug store
4142 Pontchartrain Dr Walgreens, Slidell, LA 70458
GNC
Vitamin & supplements store
150 Northshore Blvd, Slidell, LA 70460
Research & Studies
… of a novel oral formulation of S-adenosylmethionine (MSI-195) in healthy subjects: dose escalation, food effect and comparison to a commercial nutritional supplement …
BR Cameron, L Ferreira, ID MacDonald - BMC Pharmacology and …, 2020 - Springer
… The test article used in the present study has a dosage strength of 400 mg (based on the weight of the free base). The SAM-e counter-ions are disulfate tosylate and the overall tablet …
202014 citationsSafety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis
KL Soeken, WL Lee, RB Bausell, M Agelli… - J Fam Pract, 2002 - cdn.mdedge.com
… (SAMe), a dietary supplement now available in the United … 1999 as a dietary supplement to promote joint health, mobility, … 600 mg per day orally17,21,25; and one used 400 mg per …
2002174 citationsS-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial.[ISRCTN36233495]
WI Najm, S Reinsch, F Hoehler, JS Tobis… - BMC musculoskeletal …, 2004 - Springer
… S-Adenosylmethionine (SAMe) is a dietary supplement used … On most functional health measures both groups showed a … An ANOVA on pain-today scores in SAMe treated subjects with …
2004213 citationsA role for supplements in optimizing health: the metabolic tune-up
BN Ames - Archives of biochemistry and biophysics, 2004 - Elsevier
An optimum intake of micronutrients and metabolites, which varies with age and genetic constitution, would tune up metabolism and give a marked increase in health, particularly for the …
2004189 citationsA decade of nutraceutical patents: where are we now in 2018?
P Daliu, A Santini, E Novellino - Expert opinion on therapeutic …, 2018 - Taylor & Francis
… of a food that has medical or health benefits, including the … be considered in the same way as for any food supplement or … in the range between 400 mg/day and 700 mg/day. Again in …
2018164 citationsThe supplement handbook: a trusted expert's guide to what works & what's worthless for more than 100 conditions
M Moyad, J Lee - 2014 - books.google.com
… Now, more than 20 years later, I have the same position, but the endowment has grown substantially … I think the time has arrived for supplements to be included in these everyday health …
201417 citations
Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2024-07-25. DSLD Label ID: 314067. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.
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