SAMe 400 mg®
Non-Nutrient / Non-BotanicalBrand: NOW
Net Contents
60 Tablet(s)
Serving Size
1 Tablet(s)
Servings Per Container
Not specified
Supplement Form
Tablet or Pill
Bar Code (UPC/SKU)
7 33739 00141 2
Product Version
CODE 0141B V4
Label Analysis
Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.
Single-ingredient formula listed in Supplement Facts.
Every active ingredient discloses a specific amount per serving.
Label states: Vegan, Vegetarian, Gluten-Free.
This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.
Supplement Facts
Serving Size: 1 Tablet(s) · 2–4 per day
| Ingredient | Amount Per Serving | |
|---|---|---|
| SAMe | 400 mg | — |
| from 800 mg of S-Adenosyl-L-Methionine Disulfate Tosylate | 800 mg | — |
Not Present
Other Ingredients
Target Groups
Label Claims
Directions & Suggested Use
Suggested/Recommended/Usage/Directions
SUGGESTED USAGE: As a dietary supplement, take 1 tablet 2 to 4 times daily, preferably on an empty stomach.
Warnings & Precautions
Precautions re: Allergies
Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.
Precautions re: All Other
Do Not Eat Freshness Packets. Keep in Bottle.
Precautions re: All Other
Caution: For adults only. Individuals with bipolar (manic) depression and those with anxiety disorders should not take SAMe unless under professional medical supervision.
Precautions re: Pregnant or Nursing or Prescription Medications
Consult physician if pregnant/nursing, taking medication, or have a medical condition.
Precautions re: Children
Keep out of reach of children.
Storage
Storage
Refrigeration recommended after opening.
Formulation
Formulation re: Vegetarian/Vegan
Vegetarian/Vegan
Formulation re: Does NOT Contain
Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients.
FDA Statements
FDA Statement of Identity
A Dietary Supplement
FDA Disclaimer Statement
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Other Label Statements
General Statements: All Other Content
- Supports Emotional Well-Being - Supports Joint Health*
General Statements: All Other Content
ENTERIC COATED
Seals/Symbols
GMP QUALITY ASSURED
General Statements: All Other Content
For more product information visit www.nowfoods.com/0141
General Statements: All Other Content
Please Recycle.
General Statements: All Other Content
SAMe (S-adenosylmethionine), a compound native to the body, is a critical component of many biochemical reactions, including those that affect brain biochemistry and joint health. Numerous studies have indicated that SAMe can help to temporarily alleviate minor joint discomfort resulting from overexertion or stress. In addition, because SAMe is also necessary for the synthesis of neurotransmitters, it plays an important role in mood support.
Brand IP Statement(s) re: (c), (TM), (SM)
NOW(R) SAMe is enteric-coated, which makes it very well tolerated and protects it from degradation.*
General Statements: All Other Content
Made in the USA
General: Product/Version Code
CODE 0141B V4
General Statements: All Other Content
NERVOUS SYSTEM SUPPORT
Manufacturer & Distributor
Other
Distributor
NOW FOODS
395 S. Glen Ellyn Rd., Bloomingdale, IL, 60108, USA
Where to Buy Locally
Enter your city or ZIP code to find supplement & health stores in your area that may carry this product.
Showing representative supplement & health retailers — search above for stores in your area.
GNC
4.3 (40)Vitamin & supplements store
1320 Centennial Ave, Piscataway, NJ 08854
The Vitamin Shoppe
4.5 (85)Vitamin & supplements store
1579 US-22 W, Watchung, NJ 07069
Pyramid Vitamin & Health Foods
4.6 (16)Vitamin & supplements store
449 Main St, Metuchen, NJ 08840
GNC
3.2 (29)Vitamin & supplements store
907A Oak Tree Rd, South Plainfield, NJ 07080
The Vitamin Shoppe
4.5 (153)Vitamin & supplements store
185 US-1 S, Metuchen, NJ 08840
The Vitamin Shoppe
4.5 (116)Vitamin & supplements store
1255 Raritan Rd #280, Clark, NJ 07066
GNC
4.1 (39)Vitamin & supplements store
922 Easton Ave, Somerset, NJ 08873
The best nutrition
5.0 (27)Vitamin & supplements store
7 Harmony St, North Plainfield, NJ 07060
Research & Studies
… of a novel oral formulation of S-adenosylmethionine (MSI-195) in healthy subjects: dose escalation, food effect and comparison to a commercial nutritional supplement …
BR Cameron, L Ferreira, ID MacDonald - BMC Pharmacology and …, 2020 - Springer
… The test article used in the present study has a dosage strength of 400 mg (based on the weight of the free base). The SAM-e counter-ions are disulfate tosylate and the overall tablet …
202014 citationsSafety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis
KL Soeken, WL Lee, RB Bausell, M Agelli… - J Fam Pract, 2002 - cdn.mdedge.com
… (SAMe), a dietary supplement now available in the United … 1999 as a dietary supplement to promote joint health, mobility, … 600 mg per day orally17,21,25; and one used 400 mg per …
2002174 citationsS-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial.[ISRCTN36233495]
WI Najm, S Reinsch, F Hoehler, JS Tobis… - BMC musculoskeletal …, 2004 - Springer
… S-Adenosylmethionine (SAMe) is a dietary supplement used … On most functional health measures both groups showed a … An ANOVA on pain-today scores in SAMe treated subjects with …
2004213 citationsA role for supplements in optimizing health: the metabolic tune-up
BN Ames - Archives of biochemistry and biophysics, 2004 - Elsevier
An optimum intake of micronutrients and metabolites, which varies with age and genetic constitution, would tune up metabolism and give a marked increase in health, particularly for the …
2004189 citationsA decade of nutraceutical patents: where are we now in 2018?
P Daliu, A Santini, E Novellino - Expert opinion on therapeutic …, 2018 - Taylor & Francis
… of a food that has medical or health benefits, including the … be considered in the same way as for any food supplement or … in the range between 400 mg/day and 700 mg/day. Again in …
2018164 citationsThe supplement handbook: a trusted expert's guide to what works & what's worthless for more than 100 conditions
M Moyad, J Lee - 2014 - books.google.com
… Now, more than 20 years later, I have the same position, but the endowment has grown substantially … I think the time has arrived for supplements to be included in these everyday health …
201417 citations
Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2013-10-25. DSLD Label ID: 26825. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.
Related Products
01-02-Go
Pure Nootropics
100% Caffeine
MuscleTech
100% Creatine Unflavored
Six Star Pro Nutrition
100% Creatine Unflavored
Six Star Pro Nutrition