SAMe 400 mg®
Non-Nutrient / Non-BotanicalBrand: NOW
Net Contents
60 Tablet(s)
Serving Size
1 Tablet(s)
Servings Per Container
Not specified
Supplement Form
Tablet or Pill
Bar Code (UPC/SKU)
7 33739 00141 2
Product Version
CODE 0141C V7
Label Analysis
Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.
Single-ingredient formula listed in Supplement Facts.
Every active ingredient discloses a specific amount per serving.
Label states: Vegan, Vegetarian, Gluten-Free, Kosher.
This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.
Supplement Facts
Serving Size: 1 Tablet(s) · 2–3 per day
| Ingredient | Amount Per Serving | |
|---|---|---|
| SAMe(S-Adenosyl-L-Methionine Disulfate Tosylate) | 400 mg | — |
Not Present
Other Ingredients
Target Groups
Label Claims
Directions & Suggested Use
Suggested/Recommended/Usage/Directions
Suggested Usage: Take 1 tablet 2 to 3 times daily, preferably on an empty stomach.
Warnings & Precautions
Precautions re: All Other
Caution: For adults only.
Precautions re: Pregnant or Nursing or Prescription Medications
Individuals with bipolar, depression, anxiety disorders or taking antidepressant medications should not take SAMe unless under professional medical supervision. Consult physician if pregnant/nursing, taking medication, or have a medical condition.
Precautions re: Children
Keep out of reach of children.
Precautions re: Allergies
Not manufactured with wheat, gluten, soy, milk, egg, fish or shellfish ingredients. Produced in a GMP facility that produces other ingredients containing these allergens.
Storage
Storage
Refrigeration recommended after opening.
Formulation
Formula re: Contains
SAMe (S-adenoslymethionine), a compound native to the body, is a component of many biochemical reactions, including those that affect brain biochemistry and joint health. Numerous studies have indicated that SAMe can help to alleviate transient minor aches and pains resulting from overexertion or strain. In addition, because SAMe is also necessary for the synthesis of neurotransmitters, it plays an important role in mood support. NOW SAMe is enteric-coated, which makes it very well tolerated and protects it from degradation.
Formulation re: Other
Nervous system support Supports emotional well-being Supports joint health
Formulation re: Vegetarian/Vegan
Vegetarian/Vegan
Formula re: Kosher
Triangle K
Formulation re: Does NOT Contain
Not manufactured with wheat, gluten, soy, milk, egg, fish or shellfish ingredients.
Formulation re: Other
Natural color variation may occur with this product.
FDA Statements
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
FDA Statement of Identity
A Dietary Supplement
Other Label Statements
General Statements: All Other Content
New oval tablet Enteric coated
Seals/Symbols
Triangle K
General Statements: All Other Content
Amino acids Family owned since 1968.
Seals/Symbols
GMP Quality Assured
Manufacturer & Distributor
Packager
NOW Foods
395 S. Glen Ellyn Rd., Bloomingdale, IL, 60108, USA
Market Reference
NOW Foods SAMe 400 mg 30 Tablets
Vitacost.com4.7(414)$28.16NOW SAMe 400mg Tablets
Village Vitamin Store4.0(4)$36.76(2 pack) NOW Foods SAMe Nervous System Support, 400mg, 30 Ct, Size: 3.45
Walmart - Fruitful Yield4.7(414)$50.51NOW Vitamin E Mixed 400 IU 100 Softgels
NOW4.8(317)$19.99Now Foods E-400 Softgels
Vitacost.com4.7(447)$15.91NOW Foods Sun-E 400 Softgels
Swanson Health Products4.8(322)$15.66Nature Made SAM-e Complete 400 mg
Walmart4.5(310)$53.98Now SAM-E 400MG 60 tablets
William's Natural Foods4.7(414)$71.99
Where to Buy Locally
Enter your city or ZIP code to find supplement & health stores in your area that may carry this product.
Showing representative supplement & health retailers — search above for stores in your area.
Supplement Shop
2.0 (258)Vitamin & supplements store
Hohe Str. 30, 50667 Köln, Germany
Supernaturals Nutrition GmbH
4.4 (14)Vitamin & supplements store
Atelierstraße 10, 81671 München, Germany
Vitamin360
4.8 (3474)Vitamin & supplements store
Priemyselná 6734, 929 01 Dunajská Streda, Slovakia
Double - S - Nutrition
4.8 (69)Vitamin & supplements store
Arcaden Passage, Vilbeler Straße 27, 60313 Frankfurt am Main, Germany
Supplemented
4.7 (192)Vitamin & supplements store
Online Retail Ltd Box 1031A, Surbiton, Kingston upon Thames KT1 9AH, United Kingdom
Nutrition Shop Germany
3.8 (18)Vitamin & supplements store
Am Wiesenpfad 43, 53340 Meckenheim, Germany
Supplementen.nl - Supplementen BV
5.0 (32)Vitamin & supplements store
Valkenkamp 138, 3607 LH Maarssen, Netherlands
Sugars Muscle Nutrition - Online-Shop
5.0 (1)Vitamin & supplements store
ONLINE SHOP, Grandstraße 39, 45357 Essen, Germany
Research & Studies
… of a novel oral formulation of S-adenosylmethionine (MSI-195) in healthy subjects: dose escalation, food effect and comparison to a commercial nutritional supplement …
BR Cameron, L Ferreira, ID MacDonald - BMC Pharmacology and …, 2020 - Springer
… The test article used in the present study has a dosage strength of 400 mg (based on the weight of the free base). The SAM-e counter-ions are disulfate tosylate and the overall tablet …
202014 citationsSafety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis
KL Soeken, WL Lee, RB Bausell, M Agelli… - J Fam Pract, 2002 - cdn.mdedge.com
… (SAMe), a dietary supplement now available in the United … 1999 as a dietary supplement to promote joint health, mobility, … 600 mg per day orally17,21,25; and one used 400 mg per …
2002175 citationsS-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial.[ISRCTN36233495]
WI Najm, S Reinsch, F Hoehler, JS Tobis… - BMC musculoskeletal …, 2004 - Springer
… S-Adenosylmethionine (SAMe) is a dietary supplement used … On most functional health measures both groups showed a … An ANOVA on pain-today scores in SAMe treated subjects with …
2004213 citationsA role for supplements in optimizing health: the metabolic tune-up
BN Ames - Archives of biochemistry and biophysics, 2004 - Elsevier
An optimum intake of micronutrients and metabolites, which varies with age and genetic constitution, would tune up metabolism and give a marked increase in health, particularly for the …
2004190 citationsA decade of nutraceutical patents: where are we now in 2018?
P Daliu, A Santini, E Novellino - Expert opinion on therapeutic …, 2018 - Taylor & Francis
… of a food that has medical or health benefits, including the … be considered in the same way as for any food supplement or … in the range between 400 mg/day and 700 mg/day. Again in …
2018165 citationsThe supplement handbook: a trusted expert's guide to what works & what's worthless for more than 100 conditions
M Moyad, J Lee - 2014 - books.google.com
… Now, more than 20 years later, I have the same position, but the endowment has grown substantially … I think the time has arrived for supplements to be included in these everyday health …
201417 citations
Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2019-12-22. DSLD Label ID: 210365. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.
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