Dr. Joints Advancednone

Suggested/Recommended/Usage/Directions

Directions: Suggested Use: As a dietary supplement, take 3 Dr. Joints Advanced capsules once daily and with a meal. To be used as part of a healthy lifestyle with regular physical activity and a proper diet.

Storage

Store in a dry place and avoid excessive heat.

Formula re: Contains

Contains shellfish.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s) re: (c), (TM), (SM)

Calcium Fructoborate (FruiteX-B) is a registered trademark of VDF FutureCeuticals, Inc. manufactured under US Patent #5,962,049.

General Statements: All Other Content

1. McAlindon TE, LaValley MP, Gulin JP, Felson DT. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. JAMA. 283(11):1469-75. 2. Kelly GS. (1998) The role of glucosamine sulfate and chondroitin sulfates in the treatment of degenerative joint disease. Altern Med Rev. 3(1):27-39. 3. Pavelka k, et al. (2002) Glucosamine sulfate use and delay of progression of knee osteoarthritis. Arch Internal Med. 162(18):2113-23. 4. Siemandi, H. (1997) The effect of cis-9-cetyl myristoleate (CMO) and adjunctive therapy on arthritis and auto immune disease: a randomized trial. Townsend Latter for Doctors and Patients. Aug/Sept: 58-63. 5. Diehl HW, May EL. (1994) Cetyl myristoleate (CMO) isolated from Swiss albino mice: an apparent protective agent against adjuvant arthritis in rats. J Pharm Sci. 83(3): 296-9. 6. Uebelhart D, Malaise M, Marcolongo R, et al. (2004) Intermittent treatment of knee osteoarthritis with oral chondroitin sulfate: A one-year, randomize, double-blind, multicenter study versus placebo. Osteoarthritis Cartilage. 12:296-76. 7. Kahan A. (2006) Study ion Osteoarthritis Progression Prevention" a new two-year trial with chondroitin 4&6 sulfate (CS). Available at: www.ibsa-ch.com/eular_2006_amsterdam_vignon-2.pdf.

Brand IP Statement(s) re: (c), (TM), (SM)

Clinically proven FruiteX-B

General Statements: All Other Content

Significant improvements can be observed in as little as 7 days over baseline, with even greater improvement with continued use. 29% reduction in joint discomfort within 14 days vs. baseline values 8,9 {Chart} % Change Study measuring the improvement of joint comfort and mobility (WOMAC Standardization Assessment) 18% improvement 29% improvement Day 1 Day 7 Day 14

General Statements: All Other Content

8. Reyes-Izquierdo et al. (2011). Short-term intake of Calcium Fructoborate improves WOMAC and McGill scores and beneficially modulates biomarkers associated with knee osteoarthritis: A pilot clinical double-blind placebo-controlled study. American Journal of Biomedical Science. ISSN: 1937-9080. 9. Scorei et al. (2011). A double-blind, placebo-controlled pilot study to evaluate the effect of Calcium Fructoborate on systemic infalmmation and dyslipidemia markers for middle-aged people with primary osteoarthritis. Biol Trace Elem Res. 144:253-263. 10. Reyes-Izquierdo T, et al. (2014). Short-term efficacy of a combination of glucosamine and chondroitin sulfate compared to a combination of glucosamine, chondroitin sulfate and calcium Fructoborate (CFB) on improvement of knee discomfort conditions in healthy subjects. A comparative, double-blind, placebo controlled acute clinical study. Journal of Aging Research & Clinical Practice. 3(4):223-228. 11. Pietrzkowski Z, et al. (2014). Short-term efficacy of calcium Fructoborate on subjects with knee discomfort: a comparative double-blind, placebo-controlled clinical study. Clinical Interventions in Aging. 9:895-899.

General Statements: All Other Content

Joint health and wellness formula

General Statements: All Other Content

Essential joint health ingredients Glucosamine Sulfate 1,2,3 Glucosamine is a natural compound found in the body, but levels tend to decline with age. Glucosamine sulfate has been shown to significantly improve symptoms of joint discomfort and functionality. Moreover, when combined with Chondroitin, glucosamine can have an even greater effect. Cetyl-Myristoleate 4,5 Cetyl Myristoleate is a fatty acid reported to function in multiple ways: as a lubricant, as an immune system modulator, and as an anti-inflammatory agent. Studies have shown its ability to improve function and mobility in those who suffer from joint discomfort. Chondroitin 6,7 Chondroitin is a compound found naturally in human connective tissue. Research has demonstrated its efficacy in controlling joint discomfort and improving functionality, particularly in the areas of the knee and hip.

Brand IP Statement(s) re: (c), (TM), (SM)

Clinically proven FruiteX-B reduces joint discomfort and improves mobility

General Statements: All Other Content

Joint health formula Support for: Joint comfort + ease Joint flexibility + mobility Fighting joint inflammation Strengthened joint tissue

Brand IP Statement(s) re: (c), (TM), (SM)

FruiteX-B (Calcium Fructoborate) 8,9,10,11 With over a dozen published clinical studies on its unique properties and potential health benefits, Calcium Fructoborate (FruiteX-B) has been clinically proven to reduce joint discomfort and improve mobility.