SAM-e Complete 400 mg®
Other CombinationsBrand: Nature Made
Functions
Net Contents
60 Enteric Coated Tablet(s)
Serving Size
1 Tablet(s)
Servings Per Container
Not specified
Supplement Form
Tablet or Pill
Bar Code (UPC/SKU)
0 31604 01163 5
Product Version
List No: 1163 P202 Cat: A852 1A232 ITEM # 590598
Label Analysis
Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.
2 distinct active ingredients are disclosed in Supplement Facts.
Every active ingredient discloses a specific amount per serving.
Label states: Gluten-Free.
This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.
Allergen Guide
Free From
- Gluten
Allergen flags are parsed automatically from the official label's claims and statements. Always verify against the physical product label before use, especially if you have a severe allergy.
Supplement Facts
Serving Size: 1 Tablet(s) · 1 per day
| Ingredient | Amount Per Serving | |
|---|---|---|
| Protein | < 1 Gram(s) | — |
| SAM-e | 400 mg | — |
Not Present
Other Ingredients
Target Groups
Label Claims
Directions & Suggested Use
Suggested/Recommended/Usage/Directions
Suggested use: Start with 1 tablet per day. For easier swallowing, take with water before and during ingestion. The best time to take SAM-e is on an empty stomach at least 30 minutes before a meal. If benefits are not achieved within two weeks, you may require a higher level of supplementation. To determine the proper level of supplementation that works for you, gradually increase the number of tablets (maximum 1600mg/day) until benefits are achieved.
Warnings & Precautions
Precautions re: All Other
Foil blister pack ensures safety and freshness. Do not use if temper evident printed foil seal over tablets is broken.
Precautions re: Children
Store in a cool, dry place, out of reach of children.
Precautions re: All Other
Caution: People with bipolar (manic) depression or who are experiencing severe issues with mood, including thoughts of suicide, should not take this or any other product containing SAM-e except under a doctor's supervision.
Precautions re: Pregnant or Nursing or Prescription Medications
If you are pregnant or nursing, or taking prescription medications, including antidepressants, consult your doctor before using this product.
Storage
Storage
Store in a cool, dry place, out of reach of children.
Formulation
Formulation re: Does NOT Contain
This product is gluten free.
FDA Statements
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Other Label Statements
General Statements: All Other Content
SAM-e is a moisture sensitive product. That is why at Nature Made, we use foil blister packaging to ensure that each tablet of our SAM-e Complete is fresh and safe when you take it.
General Statements: All Other Content
Helps support A health mood & joint comfort Clinically studied ingredient Restores a healthy mood in as little as 7-14 days
General: Product/Version Code
List No: 1163 P202 Cat: A852 1A232 ITEM # 590598
Brand IP Statement(s) re: (c), (TM), (SM)
SAM-e Complete tablets are made to Nature Made's guaranteed purity and potency standards.
Brand IP Statement(s) re: (c), (TM), (SM)
From the #1 pharmacist recommended mood health supplement brand, Nature Made SAM-e helps support a healthy mood.
General Statements: All Other Content
When your emotions are healthy & balanced, you feel like yourself. However, sometimes emotions can get out of balance, causing you to feel moody. This imbalance can be associated with low levels of SAM-e (S-adenosylmethionine), a naturally occurring molecule produced by the body. SAM-e levels can run low due to various factors such as diet and aging. Mood improvement Days Replenish your SAM-e levels and feel the difference in as little as 7-14 days when taken daily. Helps support joint comfort Nature Made SAM-e also helps support joint comfort, which may naturally deteriorate with physical activity and age. SAM-e provides a source of sulfur, which is a critical component of joint tissue. Nature Made St. John's Wort is the #1 Pharmacist Recommended Mood Health supplement followed by Nature Made SAM-e based on the U.S. News & World Report - Pharmacy Times Survey Complete because studies have shown that SAM-e helps support a healthy mood & joint comfort
General Statements: All Other Content
Restores a healthy mood in as little as 7-14 days when taken daily
Manufacturer & Distributor
Distributor
Nature Made Nutritional Products
Mission Hills, CA, 91346-9606, U.S.A.
1-800-276-2878
Market Reference
Nature Made SAM-e Complete 400 mg
Walmart - Mayrip LLC4.6(190)$52.98
Nature Made Natural Plant Sourced Softgels
Target4.7(594)$21.78Lowest
Nature Made 400,IU Softgels (Pack of 2)
Walmart - Pharma Frills4.7(594)$25.41
Walgreens Sam-e 400 mg Coated Caplets
Walgreens.com$49.99
Sam-E, 400mg, Complete Ds Value, 36 Tablets
Med-Vet International$62.60
SAM-e 400mg
Pure Prescriptions4.7(430)$58.99
Nature Made Vitamin E 400 Iu 350 Softgels Antioxidant Ct 2 Pack Total
eBay4.7(74)$54.99
Sam-e 400mg 120 Enteric Coated Caplets (2 Boxes Of 60) - Vegan,
eBay - 123christina0_64.3(32)$112.99
Where to Buy Locally
Enter your city or ZIP code to find supplement & health stores in your area that may carry this product.
Showing representative supplement & health retailers — search above for stores in your area.
Princess Anne Nutrition Corner
5.0 (46)Vitamin & supplements store
3813 Princess Anne Rd #128, Virginia Beach, VA 23456
The Vitamin Shoppe
4.4 (255)Vitamin & supplements store
233 Independence Blvd #102, Virginia Beach, VA 23462
GNC
4.0 (25)Vitamin & supplements store
5020 Ferrell Pkwy, Virginia Beach, VA 23464
MASF Supplements
4.9 (32)Vitamin & supplements store
200 Tintern Ct #111, Chesapeake, VA 23320
Coastal Vitamin & Herb
5.0 (9)Vitamin & supplements store
1043 Kempsville Road, Providence Square Shopping Center, Virginia Beach, VA 23464
The Vitamin Shoppe
4.7 (95)Vitamin & supplements store
1721 Laskin Rd, Virginia Beach, VA 23454
Greenbrier Nutrition Corner
4.8 (21)Vitamin & supplements store
600 Jarman Rd, Chesapeake, VA 23320
The Vitamin Shoppe
4.5 (179)Vitamin & supplements store
1412 Greenbrier Pkwy #125, Chesapeake, VA 23320
Research & Studies
… of a novel oral formulation of S-adenosylmethionine (MSI-195) in healthy subjects: dose escalation, food effect and comparison to a commercial nutritional supplement …
BR Cameron, L Ferreira, ID MacDonald - BMC Pharmacology and …, 2020 - Springer
… event profile similar to the SAM-e Complete™ comparator product. The relative bioavailability of MSI-195 was approximately 2.8-fold higher than SAM-e Complete based on area under …
202014 citationsS-Adenosylmethionine (SAMe) for Central Nervous System Health: A Systematic Review
KER Baden, H McClain, E Craig, N Gibson, JA Draime… - Nutrients, 2024 - mdpi.com
… 400 mg once or twice daily, 400 mg daily titrated to 800 mg twice daily for ADHD, and 400 mg daily titrated to 800 mg … For depression, SAMe was dosed between 200 and 3200 mg daily, …
202410 citationsNutritional Supplements and PTSD.
CD Townsend - … Perspectives: Journal of the Council on …, 2018 - search.ebscohost.com
… SAM-e also helps with healthy nerve … mg twice daily, for the first day, then increase to 400 mg twice daily on day three, then to 400mg three times daily on day 10, and finally to the full …
2018Ease aching joints: natural supplements can help reduce inflammation, build cartilage, and help repair damaged joints.
B Kallen - Natural Health, 2008 - go.gale.com
… by Nature Made or Life Extension, brands that test for potency. Dosage: The current recommended intake is 400 … Some doctors suggest taking B-vitamins with SAM-e, since large …
2008Utility of nutraceutical products marketed for cognitive and memory enhancement
GJ McDougall Jr, V Austin-Wells… - Journal of Holistic …, 2005 - journals.sagepub.com
… nutraceuticals, medical and allied health care professionals … Sam-e is a shortening of the technical name and is trademarked under this name. Sam-e is used as a nutritional supplement …
200519 citationsEvidence for S-adenosyl-L-methionine (SAM-e) for the treatment of major depressive disorder.
GI Papakostas - Journal of Clinical Psychiatry, 2009 - psychiatrist.com
… increasingly interested in nonpharmaceutical supplements for treating depression. One of the best-studied of these supplements is S-adenosyl-l-methionine (SAM-e), a naturally …
2009178 citations
Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2018-07-25. DSLD Label ID: 179365. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.
Related Products
01-02 Enhanced Fat Melting Matrix
ATS Labs
1000 mg Vitamin C Acai Berry
Emergen-C
1000 mg Vitamin C Cranberry Pomegranate
Emergen-C
1000 MG Vitamin C Cranberry-Pomegranate
Emergen-C