SAM-e Complete 400 mg®

Other Combinations

Brand: Nature Made

Tablet or PillOther CombinationsOn Market
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Net Contents

60 Enteric Coated Tablet(s)

Serving Size

1 Tablet(s)

Servings Per Container

Not specified

Supplement Form

Tablet or Pill

Bar Code (UPC/SKU)

0 31604 01163 5

Product Version

List No: 1163 P202 Cat: A852 1A232 ITEM # 590598

Label Analysis

Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.

2Active Ingredients

2 distinct active ingredients are disclosed in Supplement Facts.

100%Amount Transparency

Every active ingredient discloses a specific amount per serving.

1Dietary Attributes

Label states: Gluten-Free.

This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.

Allergen Guide

Free From

  • Gluten

Allergen flags are parsed automatically from the official label's claims and statements. Always verify against the physical product label before use, especially if you have a severe allergy.

Supplement Facts

Serving Size: 1 Tablet(s) · 1 per day

IngredientAmount Per Serving
Protein< 1 Gram(s)
SAM-e400 mg

Not Present

Other Ingredients

S-Adenosylmethionine Tosylate DisulfateCellulose GelMethacrylic Acid CopolymerStearic AcidSilicon DioxideTriethyl CitrateMagnesium StearateColor addedMannitolSodium Starch Glycolate

Target Groups

Adult (18 - 50 Years)Gluten Free

Label Claims

All OtherStructure/Function

Directions & Suggested Use

Suggested/Recommended/Usage/Directions

Suggested use: Start with 1 tablet per day. For easier swallowing, take with water before and during ingestion. The best time to take SAM-e is on an empty stomach at least 30 minutes before a meal. If benefits are not achieved within two weeks, you may require a higher level of supplementation. To determine the proper level of supplementation that works for you, gradually increase the number of tablets (maximum 1600mg/day) until benefits are achieved.

Warnings & Precautions

Precautions re: All Other

Foil blister pack ensures safety and freshness. Do not use if temper evident printed foil seal over tablets is broken.

Precautions re: Children

Store in a cool, dry place, out of reach of children.

Precautions re: All Other

Caution: People with bipolar (manic) depression or who are experiencing severe issues with mood, including thoughts of suicide, should not take this or any other product containing SAM-e except under a doctor's supervision.

Precautions re: Pregnant or Nursing or Prescription Medications

If you are pregnant or nursing, or taking prescription medications, including antidepressants, consult your doctor before using this product.

Storage

Storage

Store in a cool, dry place, out of reach of children.

Formulation

Formulation re: Does NOT Contain

This product is gluten free.

FDA Statements

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Other Label Statements

General Statements: All Other Content

SAM-e is a moisture sensitive product. That is why at Nature Made, we use foil blister packaging to ensure that each tablet of our SAM-e Complete is fresh and safe when you take it.

General Statements: All Other Content

Helps support A health mood & joint comfort Clinically studied ingredient Restores a healthy mood in as little as 7-14 days

General: Product/Version Code

List No: 1163 P202 Cat: A852 1A232 ITEM # 590598

Brand IP Statement(s) re: (c), (TM), (SM)

SAM-e Complete tablets are made to Nature Made's guaranteed purity and potency standards.

Brand IP Statement(s) re: (c), (TM), (SM)

From the #1 pharmacist recommended mood health supplement brand, Nature Made SAM-e helps support a healthy mood.

General Statements: All Other Content

When your emotions are healthy & balanced, you feel like yourself. However, sometimes emotions can get out of balance, causing you to feel moody. This imbalance can be associated with low levels of SAM-e (S-adenosylmethionine), a naturally occurring molecule produced by the body. SAM-e levels can run low due to various factors such as diet and aging. Mood improvement Days Replenish your SAM-e levels and feel the difference in as little as 7-14 days when taken daily. Helps support joint comfort Nature Made SAM-e also helps support joint comfort, which may naturally deteriorate with physical activity and age. SAM-e provides a source of sulfur, which is a critical component of joint tissue. Nature Made St. John's Wort is the #1 Pharmacist Recommended Mood Health supplement followed by Nature Made SAM-e based on the U.S. News & World Report - Pharmacy Times Survey Complete because studies have shown that SAM-e helps support a healthy mood & joint comfort

General Statements: All Other Content

Restores a healthy mood in as little as 7-14 days when taken daily

Manufacturer & Distributor

Distributor

Nature Made Nutritional Products

Mission Hills, CA, 91346-9606, U.S.A.

1-800-276-2878

Market Reference

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Where to Buy Locally

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Showing representative supplement & health retailers — search above for stores in your area.

  • 健康食品添加剂

    Store

    China, Sichuan, Chengdu, Jinniu District, 站西路2号附2号 邮政编码: 610081

  • Nutrition Dabenying

    Health food store

    China, CN 重庆市 巴南区 鱼轻路 19 19号附20号 邮政编码: 401320

  • Shi Chuang You Pin Image Shop

    Drug store

    China, Henan, Pingdingshan, Ruzhou, 200, 米维也纳新城西门正南方向10米 邮政编码: 467599

  • Kangxi Nufarm

    Health food store

    238 Wanshou S St, Bozhou District, Zunyi, Guizhou, China, 563100

  • Tongkang Drugs Supermarket

    MRF2+8PJ, Renmin E Rd, Liangping District, Chongqing, China, 405299

  • GNC

    4.0 (1)

    Vitamin & supplements store

    Dongcheng, Beijing, China, 100051

  • The Vitamin Shoppe

    4.1 (115)

    Vitamin & supplements store

    45450 Dulles Crossing Plaza #185, Sterling, VA 20166, United States

  • GNC

    Vitamin & supplements store

    XC6Q+GVJ, Qisheng S Rd, Chaoyang, Beijing, China, 100013

Research & Studies

  • … of a novel oral formulation of S-adenosylmethionine (MSI-195) in healthy subjects: dose escalation, food effect and comparison to a commercial nutritional supplement …

    BR Cameron, L Ferreira, ID MacDonald - BMC Pharmacology and …, 2020 - Springer

    … event profile similar to the SAM-e Complete™ comparator product. The relative bioavailability of MSI-195 was approximately 2.8-fold higher than SAM-e Complete based on area under …

    202014 citations
  • S-Adenosylmethionine (SAMe) for Central Nervous System Health: A Systematic Review

    KER Baden, H McClain, E Craig, N Gibson, JA Draime… - Nutrients, 2024 - mdpi.com

    … 400 mg once or twice daily, 400 mg daily titrated to 800 mg twice daily for ADHD, and 400 mg daily titrated to 800 mg … For depression, SAMe was dosed between 200 and 3200 mg daily, …

    202410 citations
  • The SAM-e Solution: The Essential Guide to the Revolutionary Antidepression Supplement

    D Mitchell - 2000 - books.google.com

    … During the course of their research, investigators have found that low SAM-e levels are characteristic of many different medical conditions, which are discussed at length in this book. …

    20004 citations
  • Nutritional Supplements and PTSD.

    CD Townsend - … Perspectives: Journal of the Council on …, 2018 - search.ebscohost.com

    … SAM-e also helps with healthy nerve … mg twice daily, for the first day, then increase to 400 mg twice daily on day three, then to 400mg three times daily on day 10, and finally to the full …

    2018
  • Ease aching joints: natural supplements can help reduce inflammation, build cartilage, and help repair damaged joints.

    B Kallen - Natural Health, 2008 - go.gale.com

    … by Nature Made or Life Extension, brands that test for potency. Dosage: The current recommended intake is 400 … Some doctors suggest taking B-vitamins with SAM-e, since large …

    2008
  • Ademetionina-SAMe-Samyr

    WDSAM Do - cfsitalia.it

    … SAMe supplements, and the comprehensive scientific reference section. When reading this article keep in mind that with any health … SAM-e: This supplement should be avoided by any …

Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2018-07-25. DSLD Label ID: 179365. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.