SAMe 400 mg®
Non-Nutrient / Non-BotanicalBrand: Natrol
Net Contents
20 Enteric Coated Tablet(s)
Serving Size
2 Tablet(s)
Servings Per Container
10
Supplement Form
Tablet or Pill
Bar Code (UPC/SKU)
0 47469 16141 5
Product Version
ITEM: 16141 F: 3000008 B: 2007417-13015
Label Analysis
Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.
Single-ingredient formula listed in Supplement Facts.
Every active ingredient discloses a specific amount per serving.
Label states: Vegetarian, Gluten-Free.
This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.
Allergen Guide
Free From
- Milk
Allergen flags are parsed automatically from the official label's claims and statements. Always verify against the physical product label before use, especially if you have a severe allergy.
Supplement Facts
Serving Size: 2 Tablet(s) · 1 per day
| Ingredient | Amount Per Serving | |
|---|---|---|
| S-Adenosyl-Methionine(S-Adenosyl-Methionine Disulfate Tosylate) | 400 mg | — |
Not Present
Other Ingredients
Target Groups
Label Claims
Directions & Suggested Use
Suggested/Recommended/Usage/Directions
Directions: Take 2 tablets, one time daily, with a meal.
Warnings & Precautions
Precautions re: Pregnant or Nursing or Prescription Medications
Consult your healthcare professional prior to use if you have or suspect a medical condition, or are taking prescription drugs or any prescription antidepressant. Do not use this product if you have bipolar disorder (manic depression) or are pregnant or lactating.
Precautions re: Children
Keep out of reach of children.
Storage
Storage
Store in a cool, dry place.
Formulation
Formulation re: Does NOT Contain
No milk, egg, fish, crustacean shellfish, tree nuts, wheat, peanuts, soybeans, yeast, corn, glutens, artificial flavors, added sugar, starch or preservatives
Formula re: Contains
SAMe 400 mg per serving
Formulation re: Vegetarian/Vegan
100% vegetarian
FDA Statements
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Other Label Statements
General Statements: All Other Content
SAMe (S-Adenosyl-Methionine) is an amino acid that is produced by the body for positive mood. Diet, aging and other factors may lower SAMe levels.
Brand IP Statement(s) re: (c), (TM), (SM)
Fortunately Natrol SAMe helps support beneficial levels of SAMe in the body.
General Statements: All Other Content
SAMe is also beneficial for joint comfort and healthy liver function.
General Statements: All Other Content
Made in USA
General: Product/Version Code
ITEM: 16141 F: 3000008 B: 2007417-13015
General Statements: All Other Content
Helps support mood SAMe helps support healthy liver function Promote joint health
Manufacturer & Distributor
Distributor
NATROL, INC.
Chatsworth, CA, 91311
Market Reference
Nature Made SAM-e Complete 400 mgNature Made SAM-e Complete 400 mg
Walmart$52.97Walgreens Sam-e 400 mg Coated CapletsWalgreens Sam-e 400 mg Coated Caplets
Walgreens.comFree deliveryFree delivery$49.99Nutralife The Original SAMe 400 mg Enteric Coated TabletsNutralife The Original SAMe 400 mg Enteric Coated Tablets
TargetFree delivery on $35+Free delivery on $35+$22.99Natrol Ultra Sleep 3-in-1 Fast Dissolve TabletsNatrol Ultra Sleep 3-in-1 Fast Dissolve Tablets
WalmartNext-day delivery $7Next-day delivery $7$8.09Natrol Melatonin Free Sleep & Restore 60 CapsulesNatrol Melatonin Free Sleep & Restore 60 Capsules
TargetFree delivery on $35+Free delivery on $35+$22.99Spring Valley SAMeSpring Valley SAMe
WalmartNext-day delivery $7Next-day delivery $7$24.96Denestra SAMe 400mg 60 TabletsDenestra SAMe 400mg 60 Tablets
Chewy.comFree delivery by SatFree delivery by Sat$49.49BESTVITE Same 400mg 30 TabletsBESTVITE Same 400mg 30 Tablets
Walmart - BESTVITE INCFree deliveryFree delivery$19.99
Where to Buy Locally
Enter your city or ZIP code to find supplement & health stores in your area that may carry this product.
Showing representative supplement & health retailers — search above for stores in your area.
GNC
3.3 (23)Vitamin & supplements store
38045 47th St E, Palmdale, CA 93552
The Vitamin Shoppe
4.1 (158)Vitamin & supplements store
39256 10th St W Ste A, Palmdale, CA 93551
GNC
3.9 (70)Vitamin & supplements store
1066 W Ave K, Lancaster, CA 93534
Righteous Sports Nutrition
4.9 (19)Vitamin & supplements store
2271 E Palmdale Blvd # D, Palmdale, CA 93550
Club de Nutricion Herbalife NutriFit.
5.0 (14)Vitamin & supplements store
38209 42nd St E, Palmdale, CA 93552
Prime Time Nutrition
4.6 (51)Grocery store
2247 E Palmdale Blvd, Palmdale, CA 93550
adrianas herbal supplements
5.0 (1)Vitamin & supplements store
2520 E Palmdale Blvd #03-12, Palmdale, CA 93550
Sport Formula 99 Raw Powder Vitamins and Nutrient Blends
5.0 (132)Store
8780 19th St #217, Rancho Cucamonga, CA 91701
Research & Studies
Efficacy of the Dietary Supplement S-Adenosyl-L-Methionine
CW Fetrow, JR Avila - Annals of Pharmacotherapy, 2001 - journals.sagepub.com
… to receive oral ibuprofen 400 mg three times daily or oral SAMe 400 mg three times daily for … sold as a dietary supplement in the US under the Dietary Supplement Health Education Act. …
200163 citationsHerbs and nutrients in the treatment of depression, anxiety, insomnia, migraine, and obesity
RP Brown, PL GERBARG - Journal of Psychiatric Practice, 2001 - ovid.com
… supplements, found that only 2 out of 8 brands contained adequate hyperforin: Natures Way Standardized Extract and Natrol … Health food companies in the United States sell SAM-e in …
200159 citationsPhytochemicals as nutraceuticals: a review
JS Dhumal, AK Thikekar, AB Kumbhar… - J Neonatal …, 2025 - researchgate.net
… effects in our health and possess medicinal activities … medical or health benefits, including the prevention and treatment of disease. Such products may range from dietary supplements …
20251 citationsThe Effects of Physical Activity Programs with Nutritional Supplementation in Children Until 12 Years Old Recruited from Schools: A Systematic Review of …
M Rico-González, CD Gómez-Carmona… - Nutrients, 2025 - pmc.ncbi.nlm.nih.gov
… health, 2–3% higher increases in bone mineral content at loaded sites were reported with exercise combined with calcium supplementation. … supplementation yield synergistic health …
20256 citationsHerb-drug interactions and mechanistic and clinical considerations
XW Chen, KB Sneed, SY Pan, C Cao… - Current drug …, 2012 - ingentaconnect.com
… caplets (Natrol, each caplet contains 3.6 mg garlic powdered … through simultaneous effects on the same drug targets [14, 148]… and dietary supplement disclosure to health care providers …
2012224 citationsWeight loss nutritional supplements
JM Eckerson - Nutritional Supplements in Sports and Exercise, 2015 - Springer
… Because of the medical implications and health-care costs … nutritional weight loss supplements hoping for a quick fix, and … in the same laboratory, and supplementation occurred in …
20157 citations
Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2017-09-21. DSLD Label ID: 77813. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.
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