SPM Active

Suggested Use

Directions: Take two softgels once daily or as directed by your healthcare practitioner.

• 

  Metagenics SPM Active

  iHerb4.7(309)

  $124.95
• 

  Metagenics SPM Active Softgels

  Covenant Health Products4.6(71)

  $73.95
• 

  Metagenics SPM Active One Daily

  Metagenics4.4(200)

  $59.16
• 

  SPM Active Metagenics

  Atlanta Functional Medicine4.6(71)

  $73.95
• 

  SPM Active One Daily Metagenics 60softgels

  Life Science Pharmacy4.4(200)

  $124.95
• 

  SPM Active (Metagenics) 120 Softgels

  boulevardcompounding.com4.6(71)

  $124.95
• 

  SPM Active by Metagenics - 120 Softgels

  sheilakilbane.com

  $124.75
• 

  SPM Active | Body & Joint Soreness - 60 & 120 Softgels 120 Softgels

  Femologist4.7(309)

  $124.75

Enter your city or ZIP code to find supplement & health stores in your area that may carry this product.

Showing representative supplement & health retailers — search above for stores in your area.

• Discount Nutrition Superstore

  4.9 (1072)

  Vitamin & supplements store

  1912 E Camelback Rd, Phoenix, AZ 85016

  Directions(602) 606-2513

• Power Nutrition - Vitamins & Sports Supplements

  4.6 (33)

  Vitamin & supplements store

  5052 W Olive Ave, Glendale, AZ 85302

  Directions(623) 939-0899

• Peak Nutrition

  5.0 (470)

  Vitamin & supplements store

  6501 E Greenway Pkwy Unit 150, Scottsdale, AZ 85254

  Directions(480) 428-4999

• Performance-Supp.com

  4.8 (43)

  Vitamin & supplements store

  2636 S Wilson St Ste 104, Tempe, AZ 85282

  Directions(602) 559-2386

• Peak Nutrition

  5.0 (345)

  Vitamin & supplements store

  1840 E Warner Rd Ste 107, Tempe, AZ 85284

  Directions(480) 378-6319

• Rexius Nutrition Tempe

  5.0 (123)

  Vitamin & supplements store

  101 E Southern Ave, Tempe, AZ 85282

  Directions(602) 549-4679

• DS Sports Nutrition Scottsdale

  4.8 (78)

  Vitamin & supplements store

  18529 N Scottsdale Rd, Scottsdale, AZ 85255

  Directions(480) 607-6947

• Natural Supplements USA

  5.0 (1)

  Vitamin & supplements store

  4500 S Lakeshore Dr #510, Tempe, AZ 85282

  Directions

• Enriched marine oil supplements increase peripheral blood specialized pro-resolving mediators concentrations and reprogram host immune responses: a randomized …

  PR Souza, RM Marques, EA Gomez, RA Colas… - Circulation …, 2020 - ahajournals.org

  … Of note, recent studies found that supplementation of healthy volunteers … supplementation, given in the form of an enriched marine oil supplement SPM Active produced by Metagenics …

  2020177 citations

• Early evidence of efficacy for orally administered SPM-enriched marine lipid fraction on quality of life and pain in a sample of adults with chronic pain

  N Callan, D Hanes, R Bradley - Journal of translational medicine, 2020 - Springer

  … Generally Recognized As Safe (GRAS), commercialized by Metagenics Inc. The SPM Active… showed an acute increase in circulating SPMs in healthy individuals occurring within 2 h of …

  202042 citations

• Treatment with a marine oil supplement alters lipid mediators and leukocyte phenotype in healthy patients and those with peripheral artery disease

  MS Schaller, M Chen, RA Colas… - Journal of the …, 2020 - ahajournals.org

  … The enriched marine oil supplement test product was provided by Metagenics, Inc. It … The enriched marine lipid fraction used in this study is standardized to the SPM precursors …

  202049 citations

• Integrating downstream mediators of Omega-3 fatty acids into enteral nutrition for improved patient care: An expert panel consensus

  R Martindale, MS Mundi, D Waitzberg, E De Waele… - Clinical Nutrition, 2025 - Elsevier

  … that healthy volunteers receiving SPM precursor-enriched marine 534 oil supplements … from Metagenics Inc. JD received payment for expert 718 testimony from Perkin Coie. 719 …

  20253 citations

• Bacillus megaterium DSM 32963 Enhances Specialized Pro-Resolving Mediator Production from an n-3 PUFA Salt in a Dynamic Model of the Human …

  B Speckmann, PM Jordan, O Werz, RK Hofstetter… - Metabolites, 2025 - mdpi.com

  … healthy individuals and probed with an n-3 PUFA lysine salt with and without Bacillus megaterium DSM 32963 or an SPM-… of the dietary supplement SPM Active ® (Metagenics, Ostend, …

  20251 citations

• Inhaled toxicants and pulmonary lipid metabolism: biological consequences and therapeutic interventions

  HB Lovins, BE Bathon, SR Shaikh… - Toxicological …, 2023 - academic.oup.com

  … One field currently under investigation is the impact of diet on overall health. SPM dietary supplementation is being utilized to potentially overcome inhaled toxicant-induced …

  20238 citations

Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2020-03-24. DSLD Label ID: 216248. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.