SPM Active®

Fats & Fatty Acids

Brand: Metagenics

Softgel CapsuleFat/Fatty AcidOff Market

Product label for SPM Active — Click to view full label

Net Contents

60 Softgel(s)

Serving Size

2 Softgel(s)

Servings Per Container

Supplement Form

Softgel Capsule

Bar Code (UPC/SKU)

Not specified

Product Version

Not Present

Label Analysis

Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.

4Active Ingredients

4 distinct active ingredients are disclosed in Supplement Facts.

100%Amount Transparency

Every active ingredient discloses a specific amount per serving.

2% Daily Value Coverage

2 ingredients report an established %DV per serving.

2Dietary Attributes

Label states: Non-GMO, Gluten-Free.

This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.

Allergen Guide

Contains

Fish

Free From

Gluten

Allergen flags are parsed automatically from the official label's claims and statements. Always verify against the physical product label before use, especially if you have a severe allergy.

Supplement Facts

Serving Size: 2 Softgel(s) · 1 per day

Ingredient	Amount Per Serving	% Daily Value
Calories	10 Calorie(s)	—
Calories from Fat	10 Calorie(s)	—
Total Fat	1 Gram(s)	2%
Cholesterol	< 5 mg	2%
active fractionated Marine Lipid Concentrate(17-Hydroxy-Docosahexaenoic Acid, 18-Hydroxy-Eicosapentaenoic Acid)	1 Gram(s)	—

Percent Daily Values are based on a 2,000 calorie diet.

Other Ingredients

Fractionated Marine Lipid concentrateSoftgel shellSilica

Target Groups

Adult (18 - 50 Years)Gluten Free

Label Claims

All OtherStructure/Function

Directions & Suggested Use

Suggested/Recommended/Usage/Directions

Directions: Take two softgels once daily or as directed by your healthcare practitioner.

Warnings & Precautions

Precautions re: Pregnant or Nursing or Prescription Medications

Caution: If pregnant, nursing, or taking nutritional supplements or medications, consult your healthcare practitioner before use.

Precautions re: Children

Keep out of the reach of children.

Precautions re: All Other

Do not use if safety seal is missing or broken.

Precautions re: Allergies

Contains: Fish (anchovy, sardine, and mackerel).

Storage

Storage: Keep tightly closed in a cool dry place.

Formulation

Formulation re: Other

SPM Active is designed to help support the body's natural capacity to respond to physical challenges and resolve the immune response.

Formulation re: Does NOT Contain

This product is non-GMO and gluten-free.

Formulation re: Other

Specialized pro-resolving mediators

FDA Statements

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Other Label Statements

Brand IP Statement(s) re: (c), (TM), (SM)

Lipinova is a registered trademark of Solutex Lipinova Specialized pro-resolving lipid mediators

General Statements: All Other Content

New & improved

General Statements: All Other Content

Practitioner exclusive

Manufacturer & Distributor

Distributor

Metagenics

Gig Harbor, WA, 98332

800 692 9400

Market Reference

$14.60 – $184.99· 40 listings

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boulevardcompounding.com4.6(71)
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SPM Active | Naturally Support Relief Pain Management
Cromwell Family Chiropractic4.6(71)
$106.04

Where to Buy Locally

Enter your city or ZIP code to find supplement & health stores in your area that may carry this product.

Showing representative supplement & health retailers — search above for stores in your area.

The Vitamin Shoppe
4.2 (116)
Vitamin & supplements store
2590 David H McLeod Blvd, Florence, SC 29501
Directions (843) 669-3347
The Healthy Food Store
4.5 (148)
Health food store
2051 Elijah Ludd Rd #1, Florence, SC 29501
Directions (843) 629-9204

Research & Studies

Enriched marine oil supplements increase peripheral blood specialized pro-resolving mediators concentrations and reprogram host immune responses: a randomized …
PR Souza, RM Marques, EA Gomez, RA Colas… - Circulation …, 2020 - ahajournals.org
… Of note, recent studies found that supplementation of healthy volunteers … supplementation, given in the form of an enriched marine oil supplement SPM Active produced by Metagenics …
2020177 citations
Early evidence of efficacy for orally administered SPM-enriched marine lipid fraction on quality of life and pain in a sample of adults with chronic pain
N Callan, D Hanes, R Bradley - Journal of translational medicine, 2020 - Springer
… Generally Recognized As Safe (GRAS), commercialized by Metagenics Inc. The SPM Active… showed an acute increase in circulating SPMs in healthy individuals occurring within 2 h of …
202042 citations
Treatment with a marine oil supplement alters lipid mediators and leukocyte phenotype in healthy patients and those with peripheral artery disease
MS Schaller, M Chen, RA Colas… - Journal of the …, 2020 - ahajournals.org
… The enriched marine oil supplement test product was provided by Metagenics, Inc. It … The enriched marine lipid fraction used in this study is standardized to the SPM precursors …
202049 citations
Integrating downstream mediators of Omega-3 fatty acids into enteral nutrition for improved patient care: An expert panel consensus
R Martindale, MS Mundi, D Waitzberg, E De Waele… - Clinical Nutrition, 2025 - Elsevier
… that healthy volunteers receiving SPM precursor-enriched marine 534 oil supplements … from Metagenics Inc. JD received payment for expert 718 testimony from Perkin Coie. 719 …
20253 citations
Bacillus megaterium DSM 32963 Enhances Specialized Pro-Resolving Mediator Production from an n-3 PUFA Salt in a Dynamic Model of the Human …
B Speckmann, PM Jordan, O Werz, RK Hofstetter… - Metabolites, 2025 - mdpi.com
… healthy individuals and probed with an n-3 PUFA lysine salt with and without Bacillus megaterium DSM 32963 or an SPM-… of the dietary supplement SPM Active ® (Metagenics, Ostend, …
20251 citations
Inhaled toxicants and pulmonary lipid metabolism: biological consequences and therapeutic interventions
HB Lovins, BE Bathon, SR Shaikh… - Toxicological …, 2023 - academic.oup.com
… One field currently under investigation is the impact of diet on overall health. SPM dietary supplementation is being utilized to potentially overcome inhaled toxicant-induced …
20238 citations

Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2019-12-22. DSLD Label ID: 209824. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.