Brand: Metagenics

Tablet or PillBotanicalOn Market
Click to view full label

Net Contents

56 Tablet(s)

Serving Size

1 Tablet(s)

Servings Per Container

56

Supplement Form

Tablet or Pill

Bar Code (UPC/SKU)

7 55571 94719 2

Product Version

ESDISSAM 1544522E2

Label Analysis

Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.

1Active Ingredients

Single-ingredient formula listed in Supplement Facts.

100%Amount Transparency

Every active ingredient discloses a specific amount per serving.

3Dietary Attributes

Label states: Vegetarian, Non-GMO, Gluten-Free.

This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.

Allergen Guide

Free From

  • Gluten

Allergen flags are parsed automatically from the official label's claims and statements. Always verify against the physical product label before use, especially if you have a severe allergy.

Supplement Facts

Serving Size: 1 Tablet(s) · 1 per day

IngredientAmount Per Serving
ERr 731(Rhapontic Rhubarb Root Extract)4 mg
Rhaponticin2.2 mg
Desoxy-Rhaponticin1 mg

Not Present

Other Ingredients

Microcrystalline CelluloseStearic AcidCroscarmellose SodiumSilicaEthyl CelluloseHydroxypropyl MethylcelluloseMedium Chain TriglycerideAmmonium HydroxideSodium AlginateHydroxypropyl CelluloseOleic AcidStearic Acid

Target Groups

VegetarianWomen (not pregnant or lactating)Adult Female (18 - 50 Years)MenopauseSeniors/Mature (>50 Years) - Women ONLYGluten Free

Label Claims

All OtherStructure/Function

Directions & Suggested Use

Suggested/Recommended/Usage/Directions

Directions: Take one tablet with food and a glass of water once daily at the same time of day or as directed by your healthcare practitioner.

Suggested/Recommended/Usage/Directions

Simple dosing Well-tolerated, once-daily tablet

Warnings & Precautions

Precautions re: All Other

Notice: Do not use if you have or develop diarrhea, loose stools or abdominal pain because rhubarb may worsen these conditions and be harmful to your health. Consult your physician if you have frequent diarrhea.

Precautions re: Pregnant or Nursing or Prescription Medications

Caution: Do not use if pregnant or nursing. If taking medication, consult your healthcare practitioner before use.

Storage

Storage

Storage: Keep tightly closed in a cool, dry place.

Formulation

Formula re: Contains

Featuring ERr 731

Formula re: Contains

Also known as Siberian rhubarb root

Formulation re: Other

Estrovera's key ingredients, ERr 731, has been used safely and effectively for over 20 years and is supported by clinical studies. Estrovera provides relief for multiple menopausal symptoms, including hot flashes, sleep disturbances, mood swings, irritability, anxiety, and sexual problems.

Formulation re: Does NOT Contain

This product is non-GMO, gluten-free, and vegetarian.

Formulation re: Vegetarian/Vegan

This product is non-GMO, gluten-free, and vegetarian.

Formula re: Contains

Highly efficacious Formulated with ERr 731, which has shown up to 83% reduction in menopausal symptoms Percentages are estimated and not included in the studies. For more information please visit MetaDispensary.com. Exceptional safety profile ERr 731 recommended by healthcare professionals in Europe since 1993 This estimate ratio is not included in the publication of cumulative results of a 12-week study followed by 2 48-week observation studies (OS). It is calculated from the mean change of the MRS II total score of 5.7 at the end of the first 48-week OS divided by the baseline score of 34. There was no change in total score from the end of the first OS to the end of the second OS. These results are from the ERr 731 subgroup only, which was administered ERr 731 daily for a total of 108 weeks. This calculation does not take into account some changes in study population over time.

Formulation re: Other

Extensively studied Multiple well-designed randomized double-blind placebo-controlled studies

Formulation re: Does NOT Contain

Certified Gluten Free GFCO.org (Gluten-Free Certification Organization)

Formulation re: Other

83% decrease in daily hot flashes ERr 731 delivers non-hormonal hot flash relief, with up to an 83% decrease in daily hot flashes and other menopausal symptoms Kaszkin-Bettag M, Ventskovsky BM, Solskyy S, et al. Confirmation of the efficacy of ERr 731 in perimenopausal women with menopausal symptoms. Altern Ther Health Med. 2009; 15(1):24-34.

FDA Statements

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not included to diagnose, treat, cure, or prevent any disease.

Other Label Statements

General Statements: All Other Content

8 7-Tablet Bottles

General Statements: All Other Content

Visit MetaDispensary.com for additional information.

General Statements: All Other Content

Please recycle

Seals/Symbols

Certified Gluten Free GFCO.org (Gluten-Free Certification Organization)

General Statements: All Other Content

12-week study of 112 perimenopausal women ERr 731 subjects reported a significant decrease in the medium number of daily hot flashes compared to subjects taking placebo

General Statements: All Other Content

Number of Daily Hot Flashes Baseline Placebo 12 ERr 731 12 12 Weeks Placebo 13 ERr 731 2

Manufacturer & Distributor

Distributor

Metagenics

Gig Harbor, WA, 98332

800 692 9400

Market Reference

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  • Estrovera 90 Tablets

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Where to Buy Locally

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  • Holland & Barrett - Barrow In Furness

    4.6 (11)

    Vitamin & Supplements Shop

    206-208 Dalton Rd, Barrow-in-Furness LA14 1PR

  • Pastures New

    4.8 (8)

    Health food shop

    64-70 Scott St, Barrow-in-Furness LA14 1QE

  • LSL Supplements

    5.0 (1)

    Sports Nutrition Shop

    2 Kent St, Barrow-in-Furness LA13 9QT

Research & Studies

  • The quality, safety, and efficacy of botanical drugs

    K Palatini, S Komarnytsky - Botanical Drug Products, 2018 - api.taylorfrancis.com

    … In the United States, botanical products with health-related … Ⓡ) when compared to a dietary supplement (Estrovera), that was … launched in the US market by Metagenics Inc in 2010. The …

    20183 citations
  • Estrovera™

    F ERr - metagenicscanada.com

    … with ERr 731® (the main ingredient in Estrovera tablets) since its US introduction in 2009. This … of water once daily at the same time of day or as directed by your healthcare practitioner. …

  • Rheum rhaponticum extract (ERr 731): postmarketing data on safety surveillance and consumer complaints

    JL Chang, MB Montalto, PW Heger… - Integrative Medicine …, 2016 - pmc.ncbi.nlm.nih.gov

    … , is the senior director of medical affairs at Metagenics, Inc, in … US distributor of Estrovera were also collected and analyzed. … as the dietary supplement Estrovera (Metagenics, Aliso Viejo, …

    201627 citations
  • An Interview with Lisa McDonald, Metagenics Senior Director of Marketing and Medical Education.

    S Baker - Alternative Therapies in Health & Medicine, 2024 - search.ebscohost.com

    … about Metagenics, it’s really a leading health and wellness company specializing in nutritional supplements. I … The first is Estrovera featuring ERr731 that has been shown to reduce 12 …

    2024
  • Are You D-Prived? Vitamin D Deficiency and Why it Persists| Blog| Metagenics

    S Gottfried, L Chang, I Further - amipro.co.za

    … of vitamin D to your health and that of your patients, starting … healthcare practitioner first before starting a new supplement … ® (the extract found in Estrovera) experienced a decrease in …

  • Past News Items-January 2025

    CCMBSD First-in - imjournal.com

    … "We are deeply proud of the trust put in Metagenics by the experts within the medical … Metagenics formulates professional-grade supplements that address a variety of health and …

Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2025-02-23. DSLD Label ID: 323356. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.