5-MTHF (L-Methylfolate)

Suggested Use

DIRECTIONS: Use only as directed by a healthcare professional.

• 

  Metabolic Maintenance L-Methylfolate mg

  iHerb4.7(98)

  $50.00
• 

  Metabolic Maintenance L-Methylfolate 5mg - Gluten-free & Dairy-free Folate Supplement - Brain Supplement For Cognitive Health - Methylated Folate For

  eBay - jdjovanny4.7(98)

  $24.65
• 

  L-Methylfolate Plus Methyl-B12

  Triquetra Health4.2(267)

  $17.99
• 

  Thorne 5-MTHF 1 mg 60 Capsules

  Oakway Naturals4.8(2000)

  $24.00
• 

  5-MTHF 1 mg 60 capsules

  Life Extension4.8(2000)

  $24.00
• 

  5-MTHF 5 mg

  ThorneVet

  $68.00
• 

  VIMERGY 5-MTHF 60 Servings

  vimergy.com4.7(67)

  $47.00
• 

  Liposomal Methylfolate 5-MTHF + B12 Complex | Rho Nutrition

  Rho Nutrition4.8(75)

  $191.76

Enter your city or ZIP code to find supplement & health stores in your area that may carry this product.

Showing representative supplement & health retailers — search above for stores in your area.

• The Vitamin Shoppe

  4.6 (125)

  Vitamin & supplements store

  7300 North Point Pkwy #127, Alpharetta, GA 30022

  Directions(770) 410-7628

• Good Nutrition

  4.6 (68)

  Vitamin & supplements store

  10703 Alpharetta Hwy, Roswell, GA 30076

  Directions(770) 992-2363

• The Vitamin Shoppe

  4.3 (145)

  Vitamin & supplements store

  1165 Perimeter Center W #360, Atlanta, GA 30338

  Directions(770) 396-7152

• The Vitamin Shoppe

  4.3 (161)

  Vitamin & supplements store

  2555 Prado Ln #1430, Marietta, GA 30066

  Directions(770) 419-3492

• The Vitamin Shoppe

  4.3 (156)

  Vitamin & supplements store

  3261 Peachtree Rd, Atlanta, GA 30305

  Directions(404) 262-0400

• The Vitamin Shoppe

  4.4 (227)

  Vitamin & supplements store

  2130 Pleasant Hill Rd Suite C, Duluth, GA 30096

  Directions(678) 957-0101

• The evolution of folate supplementation–from one size for all to personalized, precision, poly-paths

  Q He, J Li - Journal of Translational Internal Medicine, 2023 - degruyterbrill.com

  … of public health. However, the … supplementation in improving folate status. [59] Studies on the safety, tolerability, and retention rates of 5-MTHF/5-MTHF-Ca have suggested that 5-MTHF-…

  202347 citations

• Folic acid, folinic acid, 5 methyl tetrahydrofolate supplementation for mutations that affect epigenesis through the folate and one-carbon cycles

  Y Menezo, K Elder, A Clement, P Clement - Biomolecules, 2022 - mdpi.com

  … FA after supplementation. UMFA … health, as will be further described here [3]. We will outline a rationale for replacing folic acid supplementation (especially at high doses) with 5-MTHF…

  2022243 citations

• Comparative Analysis of Treatment With Folate Forms in Clinical Practice

  O Skavinska, Z Rossokha, V Stefanyshyn… - Nutrition …, 2025 - academic.oup.com

  … The liver prioritizes sFA metabolism but has lower affinity for 5-MTHF, allowing some to enter … 677TT is a risk factor, and 5-MTHF supports healthy offspring in subfertile individuals. …

  20251 citations

• Vitamins, Vascular Health and Disease

  G Ayoub - Nutrients, 2025 - mdpi.com

  … form L-methylfolate throughout. We note that the full terminology is L-5-methyl-(6S)-tetrahydrofolate (L-5-MTHF) and that the term L-methylfolate is … such as L-5-MTHF have been used. In …

  202510 citations

• Folate from probiotic bacteria and its therapeutic applications

  G Megala, M Kavitha - Archives of Microbiology, 2025 - Springer

  … one-carbon metabolism, its significance in human health, folate … , folic acid supplements—either L-methylfolate or folinic acid … metabolic pathway to boost the production of L-5-MTHF, …

  20259 citations

• Is 5-methyltetrahydrofolate an alternative to folic acid for the prevention of neural tube defects?

  R Obeid, W Holzgreve, K Pietrzik - Journal of perinatal medicine, 2013 - degruyterbrill.com

  … [69] estimated that, for a 100 μg [6S]-5-MTHF supplementation over 24 weeks, plasma folate concentrations increased by 9.6 nmol/L. A doubling of total folate intake increased the folate …

  2013203 citations

Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2013-08-23. DSLD Label ID: 24708. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.