5-MTHF (L-Methylfolate)

Suggested Use

DIRECTIONS: Use only as directed by a healthcare professional.

• 

  Metabolic Maintenance L-Methylfolate mg

  iHerb4.7(98)

  $50.00
• 

  Metabolic Maintenance L-Methylfolate 5mg - Gluten-free & Dairy-free Folate Supplement - Brain Supplement For Cognitive Health - Methylated Folate For

  eBay - jdjovanny4.7(98)

  $24.65
• 

  L-Methylfolate Plus Methyl-B12

  Triquetra Health4.2(267)

  $17.99
• 

  Thorne 5-MTHF 1 mg 60 Capsules

  The Healthy Place4.8(2000)

  $24.00
• 

  Rho Liposomal Methylfolate 5-MTHF + B12 Complex

  Rho Nutrition4.8(75)

  $39.95
• 

  365 by Whole Foods Market Methyl Folate 100 Count

  Whole Foods Market

  $9.79Lowest
• 

  5 Methylfolate 5-mthf L-Methylfolate 5 mg

  methyl-life.com4.7(42)

  $44.00
• 

  Xymogen 5-MTHF Capsules

  Milltown Pharmacy4.7(7)

  $32.99

Enter your city or ZIP code to find supplement & health stores in your area that may carry this product.

Showing representative supplement & health retailers — search above for stores in your area.

• GNC

  4.7 (103)

  Vitamin & supplements store

  16039 Conneaut Lake Rd, Meadville, PA 16335

  Directions(814) 332-0720

• Comparative Analysis of Treatment With Folate Forms in Clinical Practice

  O Skavinska, Z Rossokha, V Stefanyshyn… - Nutrition …, 2025 - academic.oup.com

  … The liver prioritizes sFA metabolism but has lower affinity for 5-MTHF, allowing some to enter … 677TT is a risk factor, and 5-MTHF supports healthy offspring in subfertile individuals. …

  20251 citations

• Impact of supplementation and nutritional interventions on pathogenic processes of mood disorders: A review of the evidence

  CT Hoepner, RS McIntyre, GI Papakostas - Nutrients, 2021 - mdpi.com

  … activity with L-methylfolate and SAMe supplementation in … of a methyl group from 5-MTHF, which then forms methionine and … suggests that medical foods, particularly L-methylfolate and …

  202180 citations

• 13 Natural Medications in Psychiatry

  FA Smith, D Mischoulon - Massachusetts General Hospital …, 2015 - books.google.com

  … • Complementary and alternative medical therapies are … of 5-methyl tetrahydrofolate (5-MTHF; Deplin) supports its efficacy … L-methylfolate as adjunctive therapy for SSRI-resistant major …

  2015

• Methylenetetrahydrofolate reductase screening in treatment-resistant depression

  CCE Kandler, MAJST Lam - Federal Practitioner, 2019 - pmc.ncbi.nlm.nih.gov

  … 5-MTHF then … metabolism, L-methylfolate supplementation has been recommended. In a 60-day randomized trial of a selective serotonin reuptake inhibitor (SSRI) and L-methylfolate vs …

  201910 citations

• Applied Evidence

  BS Linn, T Mahvan, BEY Smith, AB Oung - community.the-hospitalist.org

  Marcelo G* is a 46-year-old man who presented to our family medicine clinic with a complex medical history including end-stage renal disease (ESRD) and hemodialysis, chronic …

Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2013-08-23. DSLD Label ID: 24706. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.