SAMe S-Adenosyl-Methionine 400 mg®

Non-Nutrient / Non-Botanical

Brand: Life Extension

CapsuleNon-Nutrient/Non-BotanicalOn Market

Product label for SAMe S-Adenosyl-Methionine 400 mg — Click to view full label

Net Contents

50 Enteric Coated Capsule(s)

Serving Size

1 Enteric Coated Capsule(s)

Servings Per Container

Not specified

Supplement Form

Capsule

Bar Code (UPC/SKU)

7 37870 10555 8

Product Version

Q01055D

Label Analysis

Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.

1Active Ingredients

Single-ingredient formula listed in Supplement Facts.

100%Amount Transparency

Every active ingredient discloses a specific amount per serving.

This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.

Supplement Facts

Serving Size: 1 Enteric Coated Capsule(s) · 2–3 per day

Ingredient	Amount Per Serving
S-Adenosyl-Methionine	400 mg	—

Not Present

Other Ingredients

CelluloseMannitolHydroxypropyl Methylcellulose PhthalateCitric AcidSilicaStearic AcidGlyceryl TriacetateSodium Starch GlycolateCroscarmellose SodiumTitanium Dioxideyellow Ochre

Target Groups

Adult (18 - 50 Years)

Label Claims

All OtherStructure/Function

Directions & Suggested Use

Suggested/Recommended/Usage/Directions

Read the entire label and follow the directions carefully prior to use. DIRECTIONS: Take one (1) tablet two to three times daily in divided doses, preferably on an empty stomach, or as recommended by a healthcare practitioner. Take with co-factors vitamins B12, B6, and folic acid.

Warnings & Precautions

Precautions re: All Other

CAUTION: SAMe should not be taken by those diagnosed with bipolar disorder.

Precautions re: Children

WARNINGS: ~ KEEP OUT OF REACH OF CHILDREN.

Precautions re: All Other

~ DO NOT EXCEED RECOMMENDED DOSE. ~ Do not purchase if outer seal is broken or damaged.

Precautions re: Pregnant or Nursing or Prescription Medications

~ When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Storage

Store tightly closed in a cool, dry place.

FDA Statements

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Other Label Statements

General Statements: All Other Content

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

General: Product/Version Code

Q01055D

General Statements: All Other Content

Supports Healthy Bones, Joints, and Emotional Well-Being*

Manufacturer & Distributor

Distributor

Quality Supplements and Vitamins, Inc.

Ft. Lauderdale, Florida, 33309

1-866-280-2852

info@lifeextension.com

Market Reference

$28.25 – $264.99· 14 listings

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Pure Encapsulations SAMe 60 Capsules
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Bestvite's SAMe 400mg 60 Tablets (2-Pack)
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$99.99
Omne Diem Same High Concentrated 400mg Tablets
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$61.95

Where to Buy Locally

Enter your city or ZIP code to find supplement & health stores in your area that may carry this product.

Research & Studies

Methionine restriction beyond life‐span extension
GP Ables, JR Hens… - Annals of the New York …, 2016 - Wiley Online Library
… cellular methylation capacity (S-adenosyl methionine (SAM) … the same dietary composition as those used in life-span … is a viable option for maintaining health span. Clinical trials must be …
201661 citations
Methionine restriction and mimetics to ameliorate human aging and disease
AA Parkhitko, S Pathak, JE Johnson… - Trends in Endocrinology …, 2025 - cell.com
… The possibility that dietary selenium supplementation may produce MetR-like health benefits was suggested by the observation that plasma levels of GH are dramatically reduced in rats …
20256 citations
S‐Adenosyl methionine in the therapy of depression and other psychiatric disorders
N Karas Kuželički - Drug development research, 2016 - Wiley Online Library
… S-adenosyl methionine (SAM) was discovered in 1953 by … States after the Dietary Supplement Health and Education Act … compared to healthy individuals with the same genotype. This …
201637 citations
S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial.[ISRCTN36233495]
WI Najm, S Reinsch, F Hoehler, JS Tobis… - BMC musculoskeletal …, 2004 - Springer
… S-Adenosylmethionine (SAMe) is a dietary supplement used … in health, overall health, social support, and quality of life. All … Functional health was measured with a widely used health …
2004213 citations
S-adenosylmethionine in Liver Health, Injury, and Cancer
SC Lu, JM Mato - Physiological reviews, 2012 - journals.physiology.org
… S-adenosylmethionine (AdoMet, also known as SAM and SAMe) is the principal biological … Thus a normal hepatic AdoMet level is necessary to maintain liver health and prevent injury …
2012698 citations
The efficacy of S-adenosyl methionine and probiotic supplementation on depression: a synergistic approach
H Ullah, A Khan, KRR Rengasamy, A Di Minno… - Nutrients, 2022 - mdpi.com
… S-adenosyl methionine (SAMe) supplementation has been widely studied, and an … as a dietary supplement since 1998–1999, SAMe has been proposed for many medical conditions, …
202247 citations

Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2016-04-22. DSLD Label ID: 59061. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.