SAMe S-Adenosyl-Methionine 200 mg®

Non-Nutrient / Non-Botanical

Brand: Life Extension

Tablet or PillNon-Nutrient/Non-BotanicalOn Market

Product label for SAMe S-Adenosyl-Methionine 200 mg — Click to view full label

Net Contents

50 Enteric Coated Tablet(s)

Serving Size

2 Enteric Coated Tablet(s)

Servings Per Container

Supplement Form

Tablet or Pill

Bar Code (UPC/SKU)

7 37870 45350 5

Product Version

Q00453D

Label Analysis

Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.

1Active Ingredients

Single-ingredient formula listed in Supplement Facts.

100%Amount Transparency

Every active ingredient discloses a specific amount per serving.

This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.

Supplement Facts

Serving Size: 2 Enteric Coated Tablet(s) · 2–3 per day

Ingredient	Amount Per Serving
S-Adenosyl-Methionine	400 mg	—

Not Present

Other Ingredients

CelluloseMannitolHydroxypropyl Methylcellulose PhthalateCitric AcidStearic AcidSilicaGlyceryl TriacetateSodium Starch GlycolateCroscarmellose SodiumTitanium Dioxideyellow Ochre

Target Groups

Adult (18 - 50 Years)

Label Claims

All OtherStructure/Function

Directions & Suggested Use

Suggested/Recommended/Usage/Directions

Read the entire label and follow the directions carefully prior to use. DIRECTIONS: Take two (2) tablets two to three times daily in divided doses, preferably on an empty stomach, or as recommended by a healthcare practitioner. Take with co-factors vitamins B12, B6, and folic acid.

Warnings & Precautions

Precautions re: All Other

CAUTION: SAMe should not be taken by those diagnosed with bipolar disorder.

Precautions re: Children

WARNINGS: ~ KEEP OUT OF REACH OF CHILDREN.

Precautions re: All Other

~ DO NOT EXCEED RECOMMENDED DOSE. ~ Do not purchase if outer seal is broken or damaged.

Precautions re: Pregnant or Nursing or Prescription Medications

~ When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Storage

Store tightly closed in a cool, dry place.

FDA Statements

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Other Label Statements

General: Product/Version Code

Q00453D

General Statements: All Other Content

Supports Healthy Bones, Joints, and Emotional Well-Being*

General Statements: All Other Content

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Manufacturer & Distributor

Distributor

Quality Supplements and Vitamins, Inc.

Ft. Lauderdale, FL, 33309

866-280-2852

info@lifeextension.com

Market Reference

$9.94 – $84.50· 28 listings

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Where to Buy Locally

Enter your city or ZIP code to find supplement & health stores in your area that may carry this product.

Showing representative supplement & health retailers — search above for stores in your area.

The Vitamin Shoppe
4.5 (139)
Vitamin & supplements store
130 NJ-17 Suite 14, East Rutherford, NJ 07073
Directions (201) 460-3405
EVOLUTION International
4.4 (11)
Vitamin & supplements store
Hausergasse 28, 9500 Villach, Austria
Directions +43 4242 22560

Research & Studies

Methionine restriction beyond life‐span extension
GP Ables, JR Hens… - Annals of the New York …, 2016 - Wiley Online Library
… cellular methylation capacity (S-adenosyl methionine (SAM) … the same dietary composition as those used in life-span … is a viable option for maintaining health span. Clinical trials must be …
201661 citations
S-adenosylmethionine in Liver Health, Injury, and Cancer
SC Lu, JM Mato - Physiological reviews, 2012 - journals.physiology.org
… S-adenosylmethionine (AdoMet, also known as SAM and SAMe) is the principal biological … Thus a normal hepatic AdoMet level is necessary to maintain liver health and prevent injury …
2012696 citations
The efficacy of S-adenosyl methionine and probiotic supplementation on depression: a synergistic approach
H Ullah, A Khan, KRR Rengasamy, A Di Minno… - Nutrients, 2022 - mdpi.com
… as a dietary supplement since 1998–1999, SAMe has been proposed for many medical … , were randomized to receive a combination of SAMe (200 mg) and L. plantarum HEAL9 (1 × 10 …
202247 citations
Stimulating S-adenosyl-l-methionine synthesis extends lifespan via activation of AMPK
T Ogawa, R Tsubakiyama, M Kanai, T Koyama… - Proceedings of the …, 2016 - pnas.org
… the ability of dietary restriction (DR) to both improve health and increase longevity (4–6). DR, … Because the insertion of an A at the same position failed to suppress the slow growth of the …
201664 citations
S-Adenosyl-l-Methionine Alleviates the Senescence of MSCs Through the PI3K/AKT/FOXO3a Signaling Pathway
L Shang, X Li, X Ding, G Liu, Z Pan, X Chen… - Stem Cells, 2024 - academic.oup.com
… , while taurine supplementation has been shown to improve life span in mice and health span in … S-Adenosyl methionine regulates calcium channels and inhibits uterine smooth muscle …
202413 citations
S-Adenosylmethionine (SAMe) for Central Nervous System Health: A Systematic Review
KER Baden, H McClain, E Craig, N Gibson, JA Draime… - Nutrients, 2024 - mdpi.com
… depressive symptoms were seen ranging from 200 mg to 3200 mg. Many studies started at … doses starting at 200 mg to 800 mg for mild–moderate depression and 800 mg daily in one to …
202410 citations

Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2016-04-22. DSLD Label ID: 58665. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.