SAMe 200 mg S-Adenosyl-Methionine®

Non-Nutrient / Non-Botanical

Brand: Life Extension

Tablet or PillNon-Nutrient/Non-BotanicalOn Market

Product label for SAMe 200 mg S-Adenosyl-Methionine — Click to view full label

Net Contents

30 Enteric Coated Vegetarian Tablet(s)

Serving Size

1 Enteric Coated Vegetarian Tablet(s)

Servings Per Container

Supplement Form

Tablet or Pill

Bar Code (UPC/SKU)

7 37870 21753 4

Product Version

Pkg02175D

Label Analysis

Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.

1Active Ingredients

Single-ingredient formula listed in Supplement Facts.

100%Amount Transparency

Every active ingredient discloses a specific amount per serving.

3Dietary Attributes

Label states: Vegetarian, Non-GMO, Gluten-Free.

This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.

Allergen Guide

Free From

Gluten

Allergen flags are parsed automatically from the official label's claims and statements. Always verify against the physical product label before use, especially if you have a severe allergy.

Supplement Facts

Serving Size: 1 Enteric Coated Vegetarian Tablet(s) · 1–3 per day

Ingredient	Amount Per Serving
S-Adenosyl Methionine	200 mg	—

Not Present

Other Ingredients

CelluloseMannitolMethacrylic Acid CopolymerCitric AcidStearic AcidSilicaCalcium CarbonateHypromelloseGlyceryl TriacetateSodium Starch GlycolateCroscarmellose Sodiumyellow Ochre

Target Groups

VegetarianAdult (18 - 50 Years)Gluten Free

Label Claims

All OtherStructure/Function

Directions & Suggested Use

Suggested/Recommended/Usage/Directions

Directions: Take one (1) tablet one to three times daily in divided doses, preferably on an empty stomach, or as recommended by a healthcare practitioner. Take with co-factors vitamins B12, B6, and folic acid.

Warnings & Precautions

Precautions re: All Other

Caution: SAMe should not be taken by those diagnosed with bipolar disorder.

Precautions re: Children

Warnings: Keep out of reach of children.

Precautions re: All Other

Do not exceed recommended dose. Do not purchase if foil is damaged.

Precautions re: Pregnant or Nursing or Prescription Medications

Consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Storage

Store in a cool dry place.

Formulation

Formula re: Contains

SAMe has multiple mechanisms of action that are used throughout the body

Formulation re: Other

Brain and mood SAMe boosts brain cell methylation and facilitates youthful DNA enzymatic actions. These enzymatic actions are required for the healthy conversion of neurotransmitters such as norepinephrine, dopamine, and serotonin and may account for SAMe's mood-elevating properties. SAMe also helps maintain acetylcholine levels which are necessary for cognitive function. Liver and Detox In order to perform its detoxification role, the liver continually performs large numbers of complex enzymatic reactions. SAMe facilitates healthy methylation enzymatic processes and boosts hepatic levels of glutathione, a critical antioxidant. Joint SAMe can support healthy joint mobility and function without side effects.

Formulation re: Does NOT Contain

Gluten free Non GMO LE Certified

Formulation re: Other

Supports joints and emotional well-being

FDA Statements

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Other Label Statements

Seals/Symbols

Non GMO LE Certified

Manufacturer & Distributor

Distributor

Quality Supplements and Vitamins, Inc.

Ft. Lauderdale, FL, 33309

1-866-280-2852

Market Reference

$9.94 – $84.50· 40 listings

Life Extension SAMe 200 mg 30 Tablets
Supplement First4.8(805)
$25.00
20X SAM 200μl
Zymo Research
$25.00
Life Extension Two-Per-Day
iHerb4.8(18000)
$9.94Lowest
Life Extension Fast Acting Joint Formula
iHerb4.5(445)
$29.25
Nature Made SAM-e Complete 400 mg
Walmart - Nature Made4.5(310)
$37.31
Life Extension SAMe 400 mg 30 Enteric Coated Tablets
Village Green Apothecary4.8(653)
$27.74
SAM-e 200 mg | 30 comprimidos
Bevko Vitamins
$29.99
SAMe 200mg for People
Lignans for Life4.0(2)
$25.99

Where to Buy Locally

Enter your city or ZIP code to find supplement & health stores in your area that may carry this product.

Showing representative supplement & health retailers — search above for stores in your area.

GNC
4.6 (99)
Vitamin & supplements store
9601 Carousel Ctr, Syracuse, NY 13290
Directions (315) 466-3702

Research & Studies

The efficacy of S-adenosyl methionine and probiotic supplementation on depression: a synergistic approach
H Ullah, A Khan, KRR Rengasamy, A Di Minno… - Nutrients, 2022 - mdpi.com
… as a dietary supplement since 1998–1999, SAMe has been proposed for many medical … , were randomized to receive a combination of SAMe (200 mg) and L. plantarum HEAL9 (1 × 10 …
202247 citations
S-Adenosylmethionine (SAMe) for Central Nervous System Health: A Systematic Review
KER Baden, H McClain, E Craig, N Gibson, JA Draime… - Nutrients, 2024 - mdpi.com
… depressive symptoms were seen ranging from 200 mg to 3200 mg. Many studies started at … doses starting at 200 mg to 800 mg for mild–moderate depression and 800 mg daily in one to …
202410 citations
Methionine restriction beyond life‐span extension
GP Ables, JR Hens… - Annals of the New York …, 2016 - Wiley Online Library
… cellular methylation capacity (S-adenosyl methionine (SAM) … the same dietary composition as those used in life-span … is a viable option for maintaining health span. Clinical trials must be …
201661 citations
S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial.[ISRCTN36233495]
WI Najm, S Reinsch, F Hoehler, JS Tobis… - BMC musculoskeletal …, 2004 - Springer
… -L-Methionine (SAMe) used in this study was enteric coated 200 mg tablets from 400 mg S-… , pain, change in health, overall health, social support, and quality of life. All nine items used …
2004213 citations
Stimulating S-adenosyl-l-methionine synthesis extends lifespan via activation of AMPK
T Ogawa, R Tsubakiyama, M Kanai, T Koyama… - Proceedings of the …, 2016 - pnas.org
… Because the insertion of an A at the same position failed to suppress the slow growth of the sah1-1 strain (Fig. S1G), the A-deletion mutation was suggested to be responsible for the …
201664 citations
S-adenosylmethionine
T Bottiglieri, PL Gerbarg, RP Brown - … and Integrative Treatments …, 2017 - books.google.com
… In every living cell, SAMe synthesis entails condensation of … patients should start at 200 mg/day, titrating upward slowly. … and alleviation by S-adenosyl methionine. J Neurochem 110 (3): …
20179 citations

Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2025-06-25. DSLD Label ID: 328653. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.