SAMe 200 mg S-Adenosyl-Methionine®
Non-Nutrient / Non-BotanicalBrand: Life Extension
Net Contents
30 Enteric Coated Tablet(s)
Serving Size
1 Tablet(s)
Servings Per Container
Not specified
Supplement Form
Tablet or Pill
Bar Code (UPC/SKU)
7 37870 21753 4
Product Version
Pkg02175B
Label Analysis
Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.
Single-ingredient formula listed in Supplement Facts.
Every active ingredient discloses a specific amount per serving.
Label states: Non-GMO.
This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.
Supplement Facts
Serving Size: 1 Tablet(s) · 2–6 per day
| Ingredient | Amount Per Serving | |
|---|---|---|
| S-Adenosyl-Methionine | 200 mg | — |
Not Present
Other Ingredients
Target Groups
Label Claims
Directions & Suggested Use
Suggested/Recommended/Usage/Directions
Directions: Take one (1) tablet two to six times daily in divided doses, preferably on an empty stomach, or as recommended by a healthcare practitioner. Take with co-factors vitamins B12, B6, and folic acid.
Warnings & Precautions
Precautions re: All Other
Caution: SAMe should not be taken by those diagnosed with bipolar disorder.
Precautions re: Children
Warnings: Keep out of reach of children.
Precautions re: All Other
Do not exceed recommended dose. Do not purchase if foil is broken or damaged.
Precautions re: Pregnant or Nursing or Prescription Medications
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Precautions re: All Other
To report a serious adverse event or obtain product information, contact 1-866-280-2852.
Storage
Storage
Store in a cool dry place.
Formulation
Formula re: Contains
SAMe has multiple mechanisms of action that are used throughout the body Brain and Mood SAMe boosts brain cell methylation and facilitates youthful DNA enzymatic actions. These enzymatic actions are required for the healthy conversion of neurotransmitters such as norepinephrine, dopamine, and serotonin and may account for SAMe’s mood-elevating properties. SAMe also helps maintain acetylcholine levels which are necessary for cognitive function. Liver and Detox In order to perform its detoxification role, the liver continually performs large numbers of complex enzymatic reactions. SAMe facilitates healthy methylation enzymatic processes and boosts hepatic levels of glutathione, a critical antioxidant. Joint SAMe may help to ease inflammation and can support healthy joint mobility and function without side effects.
Formulation re: Other
Supports joints and emotional well-being
Formulation re: Does NOT Contain
Non GMO LE Certified
FDA Statements
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Other Label Statements
Seals/Symbols
Non GMO LE Certified
Manufacturer & Distributor
Distributor
Quality Supplements and Vitamins, Inc.
Ft. Lauderdale, FL, 33309
1-866-280-2852
Market Reference
Life Extension SAMe 200 mg 30 Tablets
Supplement First4.8(805)$25.00Life Extension Two-Per-Day
Life Extension4.8(18000)$9.94LowestLife Extension Once Daily Health Booster
Life Extension4.7(419)$24.0020X SAM 200μl
Zymo Research$25.00Life Extension Active Vitality & Strength 30 Vegetarian Capsules
Life Extension4.2(5)$27.00Life Extension EnergyGain , 200 mg, 30 vegetarian capsules
Life Extension4.4(162)$27.00Life Extension Senolytic Activator 36 Capsules
Life Extension4.7(1400)$20.25Life Extension Vegetarian Capsules
Life Extension4.7(350)$13.50
Where to Buy Locally
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GNC
3.3 (33)Vitamin & supplements store
500 S River St, Hackensack, NJ 07601
Research & Studies
The efficacy of S-adenosyl methionine and probiotic supplementation on depression: a synergistic approach
H Ullah, A Khan, KRR Rengasamy, A Di Minno… - Nutrients, 2022 - mdpi.com
… as a dietary supplement since 1998–1999, SAMe has been proposed for many medical … , were randomized to receive a combination of SAMe (200 mg) and L. plantarum HEAL9 (1 × 10 …
202247 citationsS-Adenosylmethionine (SAMe) for Central Nervous System Health: A Systematic Review
KER Baden, H McClain, E Craig, N Gibson, JA Draime… - Nutrients, 2024 - mdpi.com
… depressive symptoms were seen ranging from 200 mg to 3200 mg. Many studies started at … doses starting at 200 mg to 800 mg for mild–moderate depression and 800 mg daily in one to …
202410 citationsMethionine restriction beyond life‐span extension
GP Ables, JR Hens… - Annals of the New York …, 2016 - Wiley Online Library
… cellular methylation capacity (S-adenosyl methionine (SAM) … the same dietary composition as those used in life-span … is a viable option for maintaining health span. Clinical trials must be …
201661 citationsS-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial.[ISRCTN36233495]
WI Najm, S Reinsch, F Hoehler, JS Tobis… - BMC musculoskeletal …, 2004 - Springer
… -L-Methionine (SAMe) used in this study was enteric coated 200 mg tablets from 400 mg S-… , pain, change in health, overall health, social support, and quality of life. All nine items used …
2004213 citationsStimulating S-adenosyl-l-methionine synthesis extends lifespan via activation of AMPK
T Ogawa, R Tsubakiyama, M Kanai, T Koyama… - Proceedings of the …, 2016 - pnas.org
… Because the insertion of an A at the same position failed to suppress the slow growth of the sah1-1 strain (Fig. S1G), the A-deletion mutation was suggested to be responsible for the …
201664 citationsS-adenosylmethionine
T Bottiglieri, PL Gerbarg, RP Brown - … and Integrative Treatments …, 2017 - books.google.com
… In every living cell, SAMe synthesis entails condensation of … patients should start at 200 mg/day, titrating upward slowly. … and alleviation by S-adenosyl methionine. J Neurochem 110 (3): …
20179 citations
Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2020-08-23. DSLD Label ID: 232841. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.
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