SAMe 200 mg S-Adenosyl-Methionine

Non-Nutrient / Non-Botanical

Brand: Life Extension

Tablet or PillOff Market
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Net Contents

30 Enteric Coated Tablet(s)

Serving Size

1 Tablet(s)

Servings Per Container

Not specified

Supplement Form

Tablet or Pill

Bar Code (UPC/SKU)

7 37870 21753 4

Product Version

Not specified

Suggested Use

Directions: Take one (1) tablet two to six times daily in divided doses; preferably on an empty stomach; or as recommended by a healthcare practitioner. Take with co-factors vitamins B12; B6; and folic acid.

Market Reference

$9.94 – $84.50· 40 listings
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    Herbs Direct4.8(798)
    $20.25
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  • Life Extension SAMe 400 mg 30 Enteric Coated Tablets

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    $27.74
  • Nature's Craft SAM-e 200 mg Capsules

    Target4.8(269)
    $20.15
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Research & Studies

  • S‐Adenosyl methionine in the therapy of depression and other psychiatric disorders

    N Karas Kuželički - Drug development research, 2016 - Wiley Online Library

    … to healthy individuals with the same genotype. … 200 mg/day), with the exception of one that used 1,600 mg/day PO. The trials indicated that the minimum SAM therapeutic dose is 400 mg/…

    201637 citations
  • S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial.[ISRCTN36233495]

    WI Najm, S Reinsch, F Hoehler, JS Tobis… - BMC musculoskeletal …, 2004 - Springer

    … -L-Methionine (SAMe) used in this study was enteric coated 200 mg tablets from 400 mg S-… , pain, change in health, overall health, social support, and quality of life. All nine items used …

    2004213 citations
  • S-adenosylmethionine

    T Bottiglieri, PL Gerbarg, RP Brown - … and Integrative Treatments …, 2017 - books.google.com

    … In every living cell, SAMe synthesis entails condensation of … patients should start at 200 mg/day, titrating upward slowly. … and alleviation by S-adenosyl methionine. J Neurochem 110 (3): …

    20179 citations
  • Excess S-adenosylmethionine inhibits methylation via catabolism to adenine

    K Fukumoto, K Ito, B Saer, G Taylor, S Ye… - Communications …, 2022 - nature.com

    … supplement (manufactured as SAMe or SAM-e) to promote emotional well-being and healthy … Is S-adenosyl methionine (SAMe) for depression only effective in males? A re-analysis of …

    202256 citations
  • S-Adenosyl-l-Methionine Alleviates the Senescence of MSCs Through the PI3K/AKT/FOXO3a Signaling Pathway

    L Shang, X Li, X Ding, G Liu, Z Pan, X Chen… - Stem Cells, 2024 - academic.oup.com

    … the reaction was terminated by adding an equal volume of PBS. The … span in mice and health span in monkeys. As an important … S-Adenosyl methionine regulates calcium channels and …

    202413 citations
  • Treatment of Depression: Roles of S-Adenosyl-L-Methionine and Folate

    JE Alpert, GI Papakostas - Natural medications for psychiatric …, 2008 - books.google.com

    … -being as well as joint health, SAMe has been the subject of … low-dose folate supplementation (200 mg) that was accompanied … S-Adenosyl-methionine in depression: a comprehensive …

    200824 citations

Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2020-08-23. DSLD Label ID: 232841. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.