Mitochondrial Basics With BioPQQ®

Suggested/Recommended/Usage/Directions

Dosage and Use - Take one (1) capsule once or twice daily, preferably early in the day, or as recommended by a healthcare practitioner. - This product can be taken with or without food.

Formula re: Contains

Pyrroloquinoline Quinone

Formula re: Contains

Mitochondrial Basics brings together three cutting-edge mitochondrial energizers in a one capsule per day, value-priced formula: 1. PQQ. This breakthrough micronutrient is technically a vitamin12-14 and has recently been shown to trigger mitochondrial biogenesis—the growth of new mitochondria in aging cells!15 PQQ also activates genes involved in protecting the delicate structures within the mitochondria.16-19 2. R-lipoic acid. The effects of free radicals comprise one of the chief obstacles to optimal mitochondrial energy production. Published studies confirm R-lipoic acid's power to promote mitochondrial bioenergetics while simultaneously blunting free radical activity.20-25 Mitochondrial Basics contains the superior Bio-Enhanced(R) R-lipoic acid and is in a proprietary microencapsulated form for better absorption. 3. Acetyl-L-carnitine arginate. Fats are shuttled into the mitochondria for metabolic combustion by the amino acid carnitine. The acetylated form of carnitine helps to facilitate more efficient utilization of fats than carnitine alone.

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

General Statements: All Other Content

Foundation for Longer Life

General Statements: All Other Content

Supports optimal mitochondrial biogenesis and function

General Statements: All Other Content

With this lower-cost option, all members have access to targeted nutrients required to support mitochondrial function and the generation of healthy new mitochondria.

Brand IP Statement(s) re: (c), (TM), (SM)

BioPQQ(R) is a registered trademark of MGC (Japan). Bio-Enhanced(R) is a registered trademark of Geronova Research, Inc. ArginoCarn(R) is a registered trademark of Sigma-tau HealthSciences, Inc. and is protected by US patents 6,365,622, US 6,703,042 and EP1202956.

General Statements: All Other Content

Behind every physiological process your body needs to survive and thrive are cellular energy generators known as mitochondria. Their function is so crucial that a growing number of scientists believe mitochondrial longevity may determine overall longevity in aging humans.1-5 One of the most serious events that cause the loss of cellular vitality is the depletion of mitochondrial energy-producing function. Cells require healthy mitochondrial activity to perform life-sustaining metabolic processes. As mitochondrial function weakens in our cells, so does the vitality of organs such as the heart and brain or in some cases, the entire body.6-11

Brand IP Statement(s) re: (c), (TM), (SM)

All Contents Copyright (C) 1995-2013 Life Extension(R) All rights reserved

General Statements: All Other Content

References 1. Biochimie. 1999 Dec;81(12):1131-2. 2. Lancet. 1989 Mar 25;1(8639):642-5. 3. Curr Opin Clin Nutr Metab Care. 2010 Jul 7. 4. Age (Dordr). 2010 Mar 20. 5. Ageing Res Rev. 2010 Jun 25. 6. Ann N Y Acad Sci. 2004 Jun;1019:406-11. 7. Postepy Biochem. 2008;54(2):129-41. 8. Ann N Y Acad Sci. 2002 Apr;959:491-507. 9. Chang Gung Med J. 2009 Mar-Apr;32(2):113-32. 10. Proc Natl Acad Sci USA. 1997 94:3064-9. 11. Ann NY Acad. Sci. 1998; 854:118-27. 12. J Neurosci Res. 2011 Feb;89(2):222-30. 13. Nature. 2003 Apr 24;422(6934):832. 14. Connect Tissue Res. 1993;29(2):153-61. 15. J Biol Chem. 2010. Jan 1;285:142-152. 16. Alt Med Rev. 2009; 14(3):268-77. 17. Entrez Gene: PARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha [Homo sapiens] GeneID: 10891. 18. Entrez Gene: CREBBP CREB binding protein [Homo sapiens] GeneID: 1387. 19. Bauerly K, Harris C, Chowanadisai W, Graham J, Havel PJ, Tchaparian E, Satre M, Karliner JS, Rucker RB. Altering pyrroloquinoline quinone nutritional status modulates mitochondrial, lipid, and energy metabolism in rats. PLoS One. 2011;6(7):e21779. Epub 2011 Jul 21. 20. Biochem Biophys Res Commun. 1996 Apr 16;221(2):422-9. 21. FASEB J. 1999 Feb;13(2):411-8. 22. Antioxid Redox Signal. 2000 Fall;2(3):473-83. 23. Biochem Mol Biol Int. 1995 Oct;37(2):361-70. 24. Arch Biochem Biophys. 2004 Mar 1;423(1):126-35. 25. Redox Rep. 2005;10(1):52-60.