SAMe 200®
Non-Nutrient / Non-BotanicalBrand: Klaire Labs
Net Contents
60 Enteric Extended Release Tablet(s)
Serving Size
1 Tablet(s)
Servings Per Container
60
Supplement Form
Tablet or Pill
Bar Code (UPC/SKU)
8 28054 01021 5
Product Version
SAM60 rev210126.02
Label Analysis
Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.
Single-ingredient formula listed in Supplement Facts.
Every active ingredient discloses a specific amount per serving.
Label states: Gluten-Free.
This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.
Allergen Guide
Contains
- Milk
- Egg
- Fish
- Shellfish
- Tree Nuts
- Peanut
- Wheat
- Soy
- Gluten
Allergen flags are parsed automatically from the official label's claims and statements. Always verify against the physical product label before use, especially if you have a severe allergy.
Supplement Facts
Serving Size: 1 Tablet(s) · 2–6 per day
| Ingredient | Amount Per Serving | |
|---|---|---|
| S-Adenosyl L-Methionine | 200 mg | — |
| S-Adenosyl L-Methionine Tosylate Disulfate | 400 mg | — |
Not Present
Other Ingredients
Target Groups
Label Claims
Directions & Suggested Use
Suggested/Recommended/Usage/Directions
Suggested Use: Adults: 1 tablet, 2 to 6 times daily or as directed by a healthcare professional. Do not chew or crush tablets.
Warnings & Precautions
Precautions re: All Other
Do not use if outer seal of blister pack is broken.
Precautions re: Children
Caution: If under 18 years of age, pregnant/nursing, have a medical condition or taking a prescription medication - including those related to mood modulation - consult your physician before use. Keep out of reach of children.
Precautions re: Pregnant or Nursing or Prescription Medications
Caution: If under 18 years of age, pregnant/nursing, have a medical condition or taking a prescription medication - including those related to mood modulation - consult your physician before use.
Precautions re: All Other
Do not exceed 1,600 mg SAMe per day (8 tablets). Do not take at night since product may cause anxiety, restlessness and insomnia.
Storage
Storage
Store in a cool, dry place (59 Degrees F - 85 Degrees F) away from direct light.
Formulation
Formula re: Contains
SAMe 200 200 mg Elemental SAMe S-Adenosyl L-Methionine
Formulation re: Other
60 Enteric Extended Release Tablets In Foil Blister Packets
Formula re: Contains
SAMe 200 is a high-quality, stabilized SAMe manufactured under low temperature and low humidity conditions. Each tablet contains a full 200 mg of elemental SAMe from 400 mg SAMe tosylate disulfate.
Formulation re: Other
These enteric extended release tablets offer improved delivery and comply with or exceed the standards for slow-release disintegration and extended release dissolution. Slow-release coating technology optimizes stability in the stomach and enhances direct release and absorption in the small intestine.
Formula re: Contains
SAMe (S-adenosylmethionine) is a derivative of the essential amino acid L-methionine and is formed by combining ATP with L-Methionine. SAMe is a chiral molecule and consists of two stereoisomers: (S,S) and (R,S). This SAMe has a high level (65%) of the (S,S) isomer, the biologically active form.
Formulation re: Other
SAMe has a long history of clinical use with proven benefits for brain metabolism, joint function, and liver detoxification. Some of the reported beneficial actions of SAMe include: Joint and Connective Tissue Strength SAMe supports production of healthy connective tissue and joint structures by contributing its sulfur component for transulfuration processes that help form glucosamine and chondroitin sulfates, critical components of connective tissues. Brain Metabolism SAMe serves as a major source of methyl groups used by the brain in the synthesis of neurotransmitters such as serotonin, L-dopa, dopamine, and related hormones involved in mood regulation. Liver Function Metabolism of SAMe supports synthesis of glutatione and glutathione-dependant enzymes (glutathione peroxidase and glutathione-S-transferase), which are important antioxidants used in liver detoxification processes.
Formulation re: Does NOT Contain
Free of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, and soybeans.
Formulation re: Other
SAMe 200 is provided in individual foil blister packets to maximize product stability.
Formulation re: Other
Produced in compliance with Good Manufacturing Practices (GMPs) and third-party quality certifications.
FDA Statements
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Other Label Statements
General Statements: All Other Content
SFI
Manufacturer & Distributor
Distributor
SFI USA
Reno, NV, 89521
Market Reference
Klaire Labs SAMe 200 Hypoallergenic S-adenosylme
SFI Health5.0(1)$49.99Klaire Labs Digestive Enzymes 180 Capsules
Pure Prescriptions5.0(8)$19.99Klaire Labs Seleno Met 200 mcg
boulevardcompounding.com4.8(7)$21.99Klaire Labs SFI Health Ther-Biotic Synbiotic 30 Capsules
Supplement First4.5(29)$49.99Klaire Labs LDA Trace Mineral Complex 30 Capsules
Arcana Empothecary4.9(25)$20.99SAMe 200
Pure Prescriptions$59.99Klaire Labs Stress Support Complex 180 Capsules
Supplement First2.3(3)$61.99Klaire Labs Vital-Zymes Complete
Arcana Empothecary5.0(11)$43.99
Where to Buy Locally
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Health Supplements Direct
4.0 (4)Vitamin & Supplements Shop
57, 63 Cheetham Hill Rd, Cheetham Hill, Manchester M8 8FS
Empire Supplements
4.8 (44)Vitamin & Supplements Shop
893 Stockport Rd, Manchester M19 3PG
PROTEIN SUPERSTORE HARTLEPOOL
5.0 (9)Vitamin & Supplements Shop
Albert Centre, 200 York Rd, Hartlepool TS26 9EB
K2protein
4.8 (25)Vitamin & Supplements Shop
Unit A4 + A35, Lord N St, Manchester M40 2HJ
1 Life Supplements
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Muscle Warehouse
5.0 (5)Health food shop
10 Cheetham St, Rochdale OL16 1DL
Supplement Hub
4.0 (6)Vitamin & Supplements Shop
The Old Chapel, 8 Mortimer St, Sheffield City Centre, Sheffield S1 4SF
The Protein Stop
4.6 (20)Vitamin & Supplements Shop
1a Andrew St, Cleveland Road, Hartlepool TS24 7LB
Research & Studies
The effect of randomized vitamin-mineral supplementation on violent and non-violent antisocial behavior among incarcerated juveniles
S SCHOENTHALER STEPHEN AMOS … - Journal of Nutritional …, 1997 - Taylor & Francis
… these were donated by Klaire Laboratories of California as a … the same test conditions in the same region and the same … and American governments, for health reasons, may reduce …
1997183 citationsHow can we improve the safe use of herbal medicine and other natural products? A clinical pharmacologist mission
EY Enioutina, KM Job, LV Krepkova… - Expert review of …, 2020 - Taylor & Francis
… and drug are metabolized by the same enzyme [Citation44]. … (eg Professional Formulas and Klaire Labs). These NPs may be … to their health care providers, and, conversely, health care …
202035 citationsThe Vaginal Microbiome: Investigations Point to a New “Normal”
ND Keegan Sheridan - ndnr.com
… a diverse ecosystem of more than 200 bacterial species. In a … long-term group received the same probiotic daily for 6 months… manufactures the Klaire Labs brand of dietary supplements. …
Welcome to Mira's Corner This is the place where integrative psychiatry meets practical wellness.
M Story - wholisticpsychiatrycare.com
… the intersection of conventional mental health care with holistic … How to use: Typical doses are 200–400 mg of elemental … , and SAMe are among the many researched supplements for …
Controlled trial of vitamin-mineral supplementation on intelligence and brain function
SJ Schoenthaler, SP Amos, WE Doraz, MA Kelly… - Personality and …, 1991 - Elsevier
… At the end of the 13 week supplementation period, there was a significant reduction in … to 2 in the supplement group (Figs 1 and 2), whereas all 8 abnormalities reappeared at the same …
199188 citationsProbiotics and disease: a comprehensive summary—part 1, mental and neurological health
KE Dolan, HJ Finley, CM Burns… - Integrative Medicine …, 2016 - pmc.ncbi.nlm.nih.gov
… Research on probiotic supplementation for neurological health is in its early stages. … they would consider probiotic supplementation as part of their care for supporting cognitive health. …
201630 citations
Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2025-04-24. DSLD Label ID: 322452. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.
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