SAMe 400 mg®
Non-Nutrient / Non-BotanicalBrand: Jarrow Formulas
Net Contents
60 Tablet(s)
Serving Size
1 Tablet(s)
Servings Per Container
60
Supplement Form
Tablet or Pill
Bar Code (UPC/SKU)
7 90011 20042 0
Product Version
12216SAM460 PROD # 120042
Label Analysis
Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.
Single-ingredient formula listed in Supplement Facts.
Every active ingredient discloses a specific amount per serving.
Label states: Vegan, Vegetarian, Gluten-Free.
This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.
Allergen Guide
Free From
- Milk
- Egg
- Fish
- Peanut
- Wheat
- Soy
- Gluten
Allergen flags are parsed automatically from the official label's claims and statements. Always verify against the physical product label before use, especially if you have a severe allergy.
Supplement Facts
Serving Size: 1 Tablet(s) · 1 per day
| Ingredient | Amount Per Serving | |
|---|---|---|
| S-Adenosyl Methionine | 400 mg | — |
| SAMe Tosylate Disulfate | 800 mg | — |
Not Present
Other Ingredients
Target Groups
Label Claims
Directions & Suggested Use
Suggested/Recommended/Usage/Directions
Usage: Take 1 tablet per day on an empty stomach or as directed by your qualified healthcare professional.
Warnings & Precautions
Precautions re: Pregnant or Nursing or Prescription Medications
Warning: Individuals using prescribed medications such as antidepressants, including Selective Serotonin Re-Uptake Inhibitors (SSRIs) and MAO Inhibitors should consult a physician before using this product.
Precautions re: All Other
Individuals with Parkinson's disease, bi-polar disorder or manic depression should not use SAMe.
Precautions re: Pregnant or Nursing or Prescription Medications
Do not use if pregnant or nursing.
Precautions re: All Other
Do not exceed recommended intake. May cause gastrointestinal upset in some persons. If you experience discomfort, discontinue use.
Precautions re: All Other
Jarrow Fomulas SAMe 400 is foil blister-packed to maximize stability and safety. Do not use if outer seal of blister pack is broken.
Precautions re: Children
Keep out of the reach of children.
Storage
Storage
Store in a cool, dry place.
Formulation
Formula re: Contains
S-Adenosyl Methionine
Formula re: Contains
Full Potency 400 mg SAMe (net yield) is derived from 800 mg of SAMe tosylate disulfate.
Formula re: Contains
S-Adenosyl Methionine 400 mg (net yield) SAMe from 800 mg SAMe Tosylate Disulfate Highest Concentration of Active S,S Form
Formulation re: Vegetarian/Vegan
Suitable for Vegetarians/Vegans.
Formulation re: Does NOT Contain
No wheat, no gluten, no soybeans, no dairy, no egg, no fish/shellfish, no peanuts/tree nuts.
Formula re: Contains
Natural SAMe 400 Jarrow Formulas SAMe 400 provides a full 400 mg SAMe (net yield) from 800 mg of SAMe tosylate disulfate. SAMe 400 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product. Contains More of the Active S,S Form Found in all living cells, SAMe is a metabolite of methionine (an essential amino acid). SAMe is a chiral molecule consisting of two forms: (S,S) SAMe and (R,S) SAMe. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive. Jarrow Formulas SAMe is made naturally by microbiological fermentation and then specially processed without chemical solvents to preserve 68-80% (S,S) SAMe, the highest active level available.
Formula re: Contains
SAMe has been clinically shown to have the following benefits: Joint Strength SAMe supports the production of healthy connective tissue through transulfuration. In this process, critical components of connective tissue known as glycosaminoglycans (GAGs), including glucosamine and chondroitin, are sulfated by SAMe metabolites to yield sulfated GAGs, such as glucosamine sulfate and chondroitin sulfate. Brain Metabolism SAMe methylation reactions are involved in the synthesis of neurotransmitters such as L-DOPA, dopamine and related hormones, serotonin, epinephrine and phosphatidylcholine (a component of lecithin). Liver SAMe metabolism supports the synthesis of glutathione (GSH) and glutathione-dependent enzymes (glutathione peroxidase, glutathione reductase and glutathione-S-transferase), which are components of the body's endogenous antioxidant network and important for liver function, including phase II detoxification.
FDA Statements
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Other Label Statements
General Statements: All Other Content
Full potency
Brand IP Statement(s) re: (c), (TM), (SM)
For best results, use the Jarrow Formulas JarroSil, the biologically Activated Silicon.
General Statements: All Other Content
In Foil Blister Pack
Brand IP Statement(s) re: (c), (TM), (SM)
New pH-Sensitive Food-grade Enteroguard coating
General Statements: All Other Content
Promotes: Joint Strength Liver Detoxification Mood and Brain Function Enteric-Coated Tablets
Seals/Symbols
Gluten free Vegan V
Brand IP Statement(s) re: (c), (TM), (SM)
EnteroGuard is a proprietary cellulose based, food-grade, pH-sensitive enteric coating that resists stomach acid and disintegrates in the less acidic pH of the upper intestines, where the SAMe is made available for absorption.
General: Product/Version Code
12216SAM460 PROD # 120042
Brand IP Statement(s) re: (c), (TM), (SM)
2016 Jarrow Formulas
Manufacturer & Distributor
Distributor
Jarrow Formulas Superior Nutrition and Formulation
P.O. Box 35994, Los Angeles, CA, 90035-4317
Market Reference
Jarrow Formulas SAM-e 400 60 Tablets
Swanson Health Products4.7(442)$62.29Jarrow Formulas SAMe 400 mg - 30 Tablets - Highest Concentration of Active S,S Form - Supports Joint Health, Liver Function, Brain Metabolism, Mood &
GoSupps.com4.8(12)$54.99Jarrow Formulas Methyl Folate
Swanson Health Products4.8(12000)$10.09Jarrow Formulas Methyl Folate 400mcg folic acid 60 vegan capsules laboratory testing gluten-free vegetarian soybean without genetic
Our Kids$13.49Bone-Up Three Per Day Jarrow Formulas
Fruitful Yield4.8(661)$37.79SAMe 400 mg 100 Tablets
Cook's Natural Foods4.7(414)$59.99NOW Foods SAMe 400 mg 30 Tablets
NOW4.7(414)$71.995 x Methyl Folate 400 Mcg 60 capsules - Jarrow Formulas
Naturitas4.8(12000)$61.90
Where to Buy Locally
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SameDaySupplements.com
4.5 (503)Vitamin & supplements store
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2360 Lakewood Rd, Toms River, NJ 08755
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8184 N Lindbergh Blvd, Florissant, MO 63031
Research & Studies
Efficacy of the Dietary Supplement S-Adenosyl-L-Methionine
CW Fetrow, JR Avila - Annals of Pharmacotherapy, 2001 - journals.sagepub.com
… to receive oral ibuprofen 400 mg three times daily or oral SAMe 400 mg three times daily for … sold as a dietary supplement in the US under the Dietary Supplement Health Education Act. …
200163 citationsBlackcurrant Supplementation and Habitual Physical Activity Enhance Functional Capacity and Quality of Life in Previously Sedentary Older Women
S Chatzopoulou, E Dimitros, M Massaro… - Current Aging …, 2024 - benthamdirect.com
… of the health benefits of polyphenol supplementation is … with dark purple gelatin capsules (Jarrow Formulas, Los Angeles, … All items contribute to the sum score with equal weight. The …
20241 citationsBest Magnesium Supplement Brands
G Mito - mitohealth.com
… a health condition. Always consult with your doctor or qualified healthcare provider before starting any new supplement … to your diet, or if you have questions about a medical condition. …
Utility of nutraceutical products marketed for cognitive and memory enhancement
GJ McDougall Jr, V Austin-Wells… - Journal of Holistic …, 2005 - journals.sagepub.com
… nutraceuticals, medical and allied health care professionals … Sam-e is a shortening of the technical name and is trademarked under this name. Sam-e is used as a nutritional supplement …
200519 citationsGet Some Structure in Your Life
K Chiarello-Ebner - wholefoodsmagazine.com
… The diet–bone health discussion often begins in the same way: calcium supports healthy bones… a branded combination bone supplement (Bone-Up from Jarrow Formulas) that contains …
Lactoferrin and Probiotic-Derived Supernatants as Adjuvants for Managing Multidrug-Resistant Opportunistic Infections
DA Costea, VA Badaluta, LI Magheran, LI Vasiliu… - 2026 - preprints.org
… Opportunistic bacteria are key drivers of healthcare… from LAB cultures were tested for the same activities. Finally, the … the association between commercial Lf (Jarrow Formulas, USA) and …
20261 citations
Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2019-04-25. DSLD Label ID: 201792. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.
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