SAMe 400®
Non-Nutrient / Non-BotanicalBrand: Jarrow Formulas
Net Contents
60 Tablet(s)
Serving Size
1 Tablet(s)
Servings Per Container
60
Supplement Form
Tablet or Pill
Bar Code (UPC/SKU)
7 90011 20042 0
Product Version
03123SAM460 PROD # 120042
Label Analysis
Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.
Single-ingredient formula listed in Supplement Facts.
Every active ingredient discloses a specific amount per serving.
Label states: Vegan, Vegetarian, Gluten-Free.
This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.
Allergen Guide
Free From
- Wheat
- Gluten
Allergen flags are parsed automatically from the official label's claims and statements. Always verify against the physical product label before use, especially if you have a severe allergy.
Supplement Facts
Serving Size: 1 Tablet(s) · 1 per day
| Ingredient | Amount Per Serving | |
|---|---|---|
| S-Adenosyl Methionine | 400 mg | — |
| SAMe Tosylate Disulfate | 800 mg | — |
Not Present
Other Ingredients
Target Groups
Label Claims
Directions & Suggested Use
Suggested/Recommended/Usage/Directions
Suggested Use: Adults take 1 tablet once a day on an empty stomach or as directed by your qualified healthcare professional.
Warnings & Precautions
Precautions re: Pregnant or Nursing or Prescription Medications
Warning: Do not use if pregnant or nursing.
Precautions re: All Other
Individuals with Parkinson’s disease, bi-polar disorder, or manic depression should not use this product. May cause gastrointestinal upset in some persons.
Precautions re: Children
Consult a healthcare professional before using this product if you are under the age of 18, are taking medication (antidepressants, selective serotonin re-uptake inhibitors (SSRIs) and MAO inhibitors) or have a medical condition; if adverse reactions occur, discontinue use. Keep out of the reach of children.
Precautions re: Pregnant or Nursing or Prescription Medications
Consult a healthcare professional before using this product if you are under the age of 18, are taking medication (antidepressants, selective serotonin re-uptake inhibitors (SSRIs) and MAO inhibitors) or have a medical condition; if adverse reactions occur, discontinue use.
Precautions re: All Other
Do not use if safety seal or blister is broken, damaged or missing.
Storage
Storage
Store in a cool, dry place.
Formulation
Formula re: Contains
Naturally Derived SAMe 400 Jarrow Formulas SAMe 400 provides a full 400 mg SAMe (net yield) from 800 mg of SAMe tosylate disulfate.
Formulation re: Other
SAMe 400 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product.
Formula re: Contains
With more of the Biologically Active S,S than R,S Form Found in all living cells, SAMe is a metabolite of methionine (an essential amino acid). SAMe is a chiral molecule consisting of two forms: (S,S) SAMe and (R,S) SAMe. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive. SAMe supports: Brain Metabolism and Mood SAMe methylation reactions are involved in the synthesis of phosphatidylcholine, a substantial constituent of grey matter within the brain and cellular membranes. It has also been proposed to be involved in the formation or metabolism of neurotransmitters, which helps to support a balanced mood. Joint Health SAMe supports the production of healthy connective tissue through transsulfuration. In this transsulfuration process, critical components of connective tissue known as glycosaminoglycans (GAGs), including glucosamine and chondroitin, are sulfated by SAMe metabolites to yield sulfated GAGs, such as glucosamine sulfate and chondroitin sulfate, the building blocks of cartilage. Liver Function SAMe supports the synthesis of glutathione (GSH), which is critical for antioxidant defenses and liver functions including phase II detoxification.
Formulation re: Does NOT Contain
Jarrow Formulas SAMe is made by microbiological fermentation and processed without chemical solvents to preserve 68-80% (S,S) SAMe.
Formula re: Contains
Naturally derived SAMe 400 S-adenosyl methionine Active S,S form Extra strength
Formula re: Contains
Jarrow Formulas SAMe 400 is foil blister-packed to maximize stability and provides 400 mg S-Adenosyl Methionine derived from 800 mg of SAMe Tosylate Disulfate.
Formulation re: Vegetarian/Vegan
Vegan
Formula re: Contains
400 mg (net yield) SAMe from 800 mg SAMe tosylate disulfate Enteroguard coating
Formulation re: Other
Extra strength Supports balanced mood, joint health, and liver function In foil blister pack
Formulation re: Does NOT Contain
Gluten free
Formulation re: Does NOT Contain
No wheat, gluten, soybeans, dairy, egg, fish/shellfish, peanuts/tree nuts or sesame.
Formula re: Contains
EnteroGuard is a proprietary cellulose-based, food-grade, pH-sensitive enteric coating that resists stomach acid and disintegrates in the less acidic pH of the upper intestines, where the SAMe is made available for absorption.
FDA Statements
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Other Label Statements
Brand IP Statement(s) re: (c), (TM), (SM)
Copyright 2023 Jarrow Formulas
General Statements: All Other Content
Mood support
Manufacturer & Distributor
Distributor
Jarrow Formulas, Inc.
Sherman Oaks, CA, 91403, USA
1-866-459-4154
Market Reference
Jarrow Formulas SAM-e 400 60 Tablets
superbhb.co.uk4.7(442)$81.98Jarrow Formulas SAMe 400 mg - 30 Tablets - Highest Concentration of Active S,S Form - Supports Joint Health, Liver Function, Brain Metabolism, Mood &
GoSupps.com4.8(12)$54.99Jarrow Formulas Methyl Folate
Swanson Health Products4.8(12000)$10.09NOW Foods SAMe 400 mg 30 Tablets
PureFormulas.com4.7(414)$26.53SAMe 400 mg 100 Tablets
Cook's Natural Foods4.7(414)$59.99Bone-Up Three Per Day Jarrow Formulas
Fruitful Yield4.8(661)$37.79NutraLife SAMe, 200 mg, 60 Enteric Coated Tablets
Swanson Health Products4.8(645)$21.48Protocol For Life Balance SAMe 400mg 60 Tablets
Summit Natural Wellness Center4.9(36)$75.00
Where to Buy Locally
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Bodystore.nl Supplements
4.7 (105)Vitamin & supplements store
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22 Rue de la République, 69002 Lyon
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400 Av. Claude Baillet, 30000 Nîmes
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224 Av. Charles de Gaulle, 71000 Mâcon
Research & Studies
… Study of Isothiocyanates and Other Bioactive Compounds of Brassica oleracea L. var. Italica Boiled or Steamed: Functional Food or Dietary Supplement?
P Orlando, A Nartea, S Silvestri, F Marcheggiani, I Cirilli… - Antioxidants, 2022 - mdpi.com
… method to promote the health benefits of broccoli in the diet. … % = 100), and the same amount of broccoli was cooked at 99 … 3 capsules of BroccoMax ® (Jarrow Formulas, California, LA, …
202228 citationsEfficacy of the Dietary Supplement S-Adenosyl-L-Methionine
CW Fetrow, JR Avila - Annals of Pharmacotherapy, 2001 - journals.sagepub.com
… A single oral dose of SAMe 400 mg … SAMe has been available for use in Europe for several years and is sold as a dietary supplement in the US under the Dietary Supplement Health …
200163 citationsRestoration of Blood Total Glutathione Status and Lymphocyte Function Following α-Lipoic Acid Supplementation in Patients with HIV Infection
RJ Jariwalla, J Lalezari, D Cenko… - … Integrative Health, 2008 - journals.sagepub.com
… group were given ALA supplement (ALA 300 sustain, provided by Jarrow Formulas, Los Angeles, CA) at a dose of 300 mg three times daily for 6 months. Patients in the control group …
200868 citationsNatural Digestive Care That's Easy to Swallow
K Chiarello-Ebner - wholefoodsmagazine.com
… of Health Sciences and consultant to Jarrow Formulas, Los … moisture, Jarrow Formulas’ Jarro-Dophilus EPS supplement is … to find a formula with multiple strains of the same enzyme in …
Taking Back Control
T Person - wholefoodsmagazine.com
… Jarrow Formulas) has been shown to aid insulin with blood sugar regulation, while other forms of HCA have not shown the same … that supplement manufacturers and natural health …
Lactoferrin and Probiotic-Derived Supernatants as Adjuvants for Managing Multidrug-Resistant Opportunistic Infections
DA Costea, VA Badaluta, LI Magheran, LI Vasiliu… - 2026 - preprints.org
… Opportunistic bacteria are key drivers of healthcare… from LAB cultures were tested for the same activities. Finally, the … the association between commercial Lf (Jarrow Formulas, USA) and …
20261 citations
Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2024-05-23. DSLD Label ID: 307732. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.
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