SAMe 400®
Non-Nutrient / Non-BotanicalBrand: Jarrow Formulas
Net Contents
30 Tablet(s)
Serving Size
1 Tablet(s)
Servings Per Container
30
Supplement Form
Tablet or Pill
Bar Code (UPC/SKU)
7 90011 20020 8
Product Version
03123SAM400 PROD # 120020
Label Analysis
Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.
Single-ingredient formula listed in Supplement Facts.
Every active ingredient discloses a specific amount per serving.
Label states: Vegan, Vegetarian, Gluten-Free.
This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.
Allergen Guide
Free From
- Wheat
Allergen flags are parsed automatically from the official label's claims and statements. Always verify against the physical product label before use, especially if you have a severe allergy.
Supplement Facts
Serving Size: 1 Tablet(s) · 1 per day
| Ingredient | Amount Per Serving | |
|---|---|---|
| S-Adenosyl Methionine | 400 mg | — |
| SAMe Tosylate Disulfate | 800 mg | — |
Not Present
Other Ingredients
Target Groups
Label Claims
Directions & Suggested Use
Suggested/Recommended/Usage/Directions
Suggested use: Adults take 1 tablet once a day on an empty stomach or as directed by your qualified healthcare professional.
Warnings & Precautions
Precautions re: Pregnant or Nursing or Prescription Medications
Warning: Do not use if pregnant or nursing. Individuals with Parkinson's disease, bi-polar disorder, or manic depression should not use this product. Consult a healthcare professional before using this product if you are under the age of 18, are taking medication (antidepressants, selective serotonin re-uptake inhibitors (SSRIs) and MAO inhibitors) or have a medical condition; if adverse reactions occur, discontinue use.
Precautions re: Children
Consult a healthcare professional before using this product if you are under the age of 18, are taking medication (antidepressants, selective serotonin re-uptake inhibitors (SSRIs) and MAO inhibitors) or have a medical condition; if adverse reactions occur, discontinue use.
Precautions re: Children
Keep out of the reach of children.
Precautions re: All Other
May cause gastrointestinal upset in some persons.
Precautions re: All Other
Do not use if safety seal or blister is broken, damaged or missing.
Storage
Storage
Store in a cool, dry place.
Formulation
Formula re: Contains
Naturally Derived SAMe 400 Jarrow Formulas SAMe 400 provides a full 400 mg SAMe (net yield) from 800 mg of SAMe tosylate disulfate. With more of the Biologically Active S,S than R,S Form Found in all living cells, SAMe is a metabolite of methionine (an essential amino acid). SAMe is a chiral molecule consisting of two forms: (S,S) SAMe and (R,S) SAMe. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive.
Formulation re: Other
SAMe 400 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product.
Formulation re: Does NOT Contain
Jarrow Formulas SAMe is made naturally by microbiological fermentation and processed without chemical solvents to preserve 68-80% (S,S) SAMe.
Formula re: Contains
SAMe supports: Brain Metabolism and Mood SAMe methylation reactions are involved in the synthesis of phosphatidylcholine, a substantial constituent of grey matter within the brain and cellular membranes. It has also been proposed to be involved in the formation or metabolism of neurotransmitters, which helps to support a balanced mood. Joint Health SAMe supports the production of healthy connective tissue through transsulfuration. In this transsulfuration process, critical components of connective tissue known as glycosaminoglycans (GAGs), including glucosamine and chondroitin, are sulfated by SAMe metabolites to yield sulfated GAGs, such as glucosamine sulfate and chondroitin sulfate, the building blocks of cartilage. Liver Function SAMe supports the synthesis of glutathione (GSH), which is critical for antioxidant defenses and liver functions including phase II detoxification.
Formula re: Contains
Jarrow Formulas SAMe 400 is foil blister-packed to maximize stability and provides 400 mg S-Adenosyl Methionine derived from 800 mg of SAMe Tosylate Disulfate.
Formulation re: Vegetarian/Vegan
Vegan
Formula re: Contains
S-Adenosyl methionine active S,S form 400 mg (net yield) SAMe from 800 mg SAMe tosylate disulfate
Formulation re: Other
Naturally derived Extra strength Supports balanced mood, joint health, and liver function Mood support In foil blister pack
Formula re: Contains
EnteroGuard Coating
Formulation re: Does NOT Contain
No wheat, gluten, soybeans, dairy, egg, fish/shellfish, peanuts/tree nuts or sesame.
Formula re: Contains
EnteroGuard is a proprietary cellulose-based, food-grade, pH-sensitive enteric coating that resists stomach acid and disintegrates in the less acidic pH of the upper intestines, where the SAMe is made available for absorption.
FDA Statements
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Other Label Statements
Brand IP Statement(s) re: (c), (TM), (SM)
Copyright 2023 Jarrow Formulas
General Statements: All Other Content
Mood support
Manufacturer & Distributor
Distributor
Jarrow Formulas, Inc.
Sherman Oaks, CA, 91403, USA
1-866-459-4154
Market Reference
Jarrow Formulas SAM-e 400 60 Tablets
Jarrow Formulas4.7(442)$48.99Jarrow Formulas SAMe 400 mg - 30 Tablets - Highest Concentration of Active S,S Form - Supports Joint Health, Liver Function, Brain Metabolism, Mood &
GoSupps.com4.8(12)$54.99Jarrow Formulas Methyl Folate
Professional Supplement Center4.8(12000)$10.99Jarrow Formulas Joint & Muscle Support 120 Capsules
Whole Foods Market4.7(1600)$39.99NOW Foods SAMe 400 mg 30 Tablets
Target4.7(414)$48.99Jarro-Dophilus EPS Jarrow Formulas
Whole Foods Market4.7(4500)$38.39Jarrow Formulas Whey Protein Unflavored 2 lbs.
Target4.7(473)$43.57BESTVITE Same 400mg 30 Tablets
Walmart - BESTVITE INC4.7(192)$19.99
Where to Buy Locally
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R Supplements LTD
5.0 (89)Vitamin & Supplements Shop
27 Colinglen Rd, Dunmurry, Belfast BT17 0LR
HUMAC Supplements Ltd.
5.0 (26)Vitamin & Supplements Shop
The Alders, 50 Carrington, Northwood Ave, Santry Demesne, Dublin, D09 E6K4, Ireland
GourmetFuel
4.8 (259)Meal Delivery
T30 Rowan Ave, Stillorgan Business Park, Dublin, A94 V326, Ireland
Power Body Nutrition Ltd
4.4 (41)Vitamin & Supplements Shop
11 Chessingham Park, Dunnington, York YO19 5SE
Supplement Solutions
4.9 (19)Vitamin & Supplements Shop
The Weind, Great Eccleston, Preston PR3 0XJ
Huxley Europe
3.0 (1)Manufacturer
26 Whittaker Ln, Prestwich, Manchester M25 1FX
PUREPOWER Nutrition
4.0 (74)Food products supplier
UNIT 56 Grange Rd, Baldoyle Industrial Estate, Dublin, D13 FY53, Ireland
Lir Pharmacy
4.2 (252)Vitamin & Supplements Shop
Plaza Pharmacy Unit 2, Swords Plaza, Townparks, Swords, Co. Dublin, K67 X7P6, Ireland
Research & Studies
… Study of Isothiocyanates and Other Bioactive Compounds of Brassica oleracea L. var. Italica Boiled or Steamed: Functional Food or Dietary Supplement?
P Orlando, A Nartea, S Silvestri, F Marcheggiani, I Cirilli… - Antioxidants, 2022 - mdpi.com
… method to promote the health benefits of broccoli in the diet. … % = 100), and the same amount of broccoli was cooked at 99 … 3 capsules of BroccoMax ® (Jarrow Formulas, California, LA, …
202228 citationsEfficacy of the Dietary Supplement S-Adenosyl-L-Methionine
CW Fetrow, JR Avila - Annals of Pharmacotherapy, 2001 - journals.sagepub.com
… A single oral dose of SAMe 400 mg … SAMe has been available for use in Europe for several years and is sold as a dietary supplement in the US under the Dietary Supplement Health …
200163 citationsRestoration of Blood Total Glutathione Status and Lymphocyte Function Following α-Lipoic Acid Supplementation in Patients with HIV Infection
RJ Jariwalla, J Lalezari, D Cenko… - … Integrative Health, 2008 - journals.sagepub.com
… group were given ALA supplement (ALA 300 sustain, provided by Jarrow Formulas, Los Angeles, CA) at a dose of 300 mg three times daily for 6 months. Patients in the control group …
200868 citationsNatural Digestive Care That's Easy to Swallow
K Chiarello-Ebner - wholefoodsmagazine.com
… of Health Sciences and consultant to Jarrow Formulas, Los … moisture, Jarrow Formulas’ Jarro-Dophilus EPS supplement is … to find a formula with multiple strains of the same enzyme in …
Taking Back Control
T Person - wholefoodsmagazine.com
… Jarrow Formulas) has been shown to aid insulin with blood sugar regulation, while other forms of HCA have not shown the same … that supplement manufacturers and natural health …
Lactoferrin and Probiotic-Derived Supernatants as Adjuvants for Managing Multidrug-Resistant Opportunistic Infections
DA Costea, VA Badaluta, LI Magheran, LI Vasiliu… - 2026 - preprints.org
… Opportunistic bacteria are key drivers of healthcare… from LAB cultures were tested for the same activities. Finally, the … the association between commercial Lf (Jarrow Formulas, USA) and …
20261 citations
Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2024-01-24. DSLD Label ID: 307731. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.
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