SAMe 400®
Non-Nutrient / Non-BotanicalBrand: Jarrow Formulas
Net Contents
60 Tablet(s)
Serving Size
1 Tablet(s)
Servings Per Container
60
Supplement Form
Tablet or Pill
Bar Code (UPC/SKU)
7 90011 20042 0
Product Version
06221SAM460 PROD # 120042
Label Analysis
Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.
Single-ingredient formula listed in Supplement Facts.
Every active ingredient discloses a specific amount per serving.
Label states: Vegan, Vegetarian, Gluten-Free.
This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.
Allergen Guide
Free From
- Gluten
Allergen flags are parsed automatically from the official label's claims and statements. Always verify against the physical product label before use, especially if you have a severe allergy.
Supplement Facts
Serving Size: 1 Tablet(s) · 1 per day
| Ingredient | Amount Per Serving | |
|---|---|---|
| S-Adenosyl Methionine | 400 mg | — |
| SAMe Tosylate Disulfate | 800 mg | — |
Not Present
Other Ingredients
Target Groups
Label Claims
Directions & Suggested Use
Suggested/Recommended/Usage/Directions
Usage: Take 1 tablet per day on an empty stomach or as directed by your qualified healthcare professional.
Suggested/Recommended/Usage/Directions
For best results, use with Jarrow Formulas JarroSil, the biologically Activated Silicon.
Warnings & Precautions
Precautions re: Pregnant or Nursing or Prescription Medications
Warning: Individuals using prescribed medications such as antidepressants, including Selective Serotonin Re-Uptake Inhibitors (SSRIs) and MAO Inhibitors should consult a physician before using this product. Individuals with Parkinson’s disease, bi-polar disorder or manic depression should not use SAMe. Do not use if pregnant or nursing.
Precautions re: All Other
Do not exceed recommended intake. May cause gastrointestinal upset in some persons. Consult a healthcare professional before using this product if you are trying to conceive, under the age of 18, or have a medical condition; if adverse reactions occur, discontinue use.
Precautions re: Children
Consult a healthcare professional before using this product if you are trying to conceive, under the age of 18, or have a medical condition; if adverse reactions occur, discontinue use.
Precautions re: All Other
Jarrow Formulas SAMe 400 is foil blister-packed to maximize stability and safety. Do not use if outer seal of blister pack is broken.
Precautions re: Children
Keep out of the reach of children.
Storage
Storage
Store in a cool, dry place.
Formulation
Formula re: Contains
Natural SAMe 400 Jarrow Formulas SAMe 400 provides a full 400 mg SAMe (net yield) from 800 mg of SAMe tosylate disulfate. SAMe 400 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product. Contains More of the Active S,S Form Found in all living cells, SAMe is a metabolite of methionine (an essential amino acid). SAMe is a chiral molecule consisting of two forms: (S,S) SAMe and (R,S) SAMe.
Formulation re: Other
The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive.
Formula re: Contains
Jarrow Formulas SAMe is made naturally by microbiological fermentation and then specially processed without chemical solvents to preserve 68-80% (S,S) SAMe, the highest active level available.
Formulation re: Other
SAMe supports: Joint Health SAMe supports the production of healthy connective tissue through transulfuration. In this process, critical components of connective tissue known as glycosaminoglycans (GAGs), including glucosamine and chondroitin, are sulfated by SAMe metabolites to yield sulfated GAGs, such as glucosamine sulfate and chondroitin sulfate. Brain Metabolism and Mood SAMe methylation reactions are involved in the synthesis of phosphatidylcholine, a substantial constituent of grey matter within the brain and cellular membranes and precursor to acetylcholine, as well as neurotransmitters such as dopamine, norepinephrine, and serotonin, and has been shown to have a positive effect on mood. Liver Function SAMe metabolism supports the synthesis of glutathione (GSH), which is critical for antioxidant defenses and liver functions including phase II detoxification.
Formula re: Contains
S-Adenosyl Methionine
Formulation re: Other
Full potency
Formula re: Contains
Full Potency 400 mg SAMe (net yield) is derived from 800 mg of SAMe tosylate disulfate.
Formula re: Contains
Natural pH-sensitive Food-grade EnteroGuard Coating
Formula re: Contains
S-Adenosyl Methionine 400 mg (net yield) SAMe from 800 mg SAMe tosylate disulfate Highest concentration of Active S,S Form
Formulation re: Other
Supports: Joint health Brain metabolism and mood Liver function
Formula re: Contains
Enteric-Coated Tablets
Formula re: Contains
EnteroGuard is a proprietary cellulose-based, food-grade, pH-sensitive enteric coating that resists stomach acid and disintegrates in the less acidic pH of the upper intestines, where the SAMe is made available for absorption.
Formulation re: Does NOT Contain
Gluten free
Formulation re: Vegetarian/Vegan
V Vegan
FDA Statements
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Other Label Statements
Brand IP Statement(s) re: (c), (TM), (SM)
Copyright 2021 Jarrow Formulas
General Statements: All Other Content
In foil blister pack
Manufacturer & Distributor
Distributor
Jarrow Formulas
Los Angeles, CA, 90035-4317
1-866-459-4154
Market Reference
Jarrow Formulas SAM-e 400 60 Tablets
Jarrow Formulas4.7(442)$48.99Jarrow Formulas SAMe 400 mg - 30 Tablets - Highest Concentration of Active S,S Form - Supports Joint Health, Liver Function, Brain Metabolism, Mood &
GoSupps.com4.8(12)$54.99Jarrow Formulas Methyl Folate
Swanson Health Products4.8(12000)$10.09Jarrow Formulas Methyl Folate 400mcg folic acid 60 vegan capsules laboratory testing gluten-free vegetarian soybean without genetic
Pure Prescriptions$13.49SAMe 400 mg - 60 tabs
Nutriessential.com$64.79SAMe 400 mg 100 Tablets
Cook's Natural Foods4.7(414)$59.995 x Methyl Folate 400 Mcg 60 capsules - Jarrow Formulas
Naturitas4.8(12000)$61.90Bone-Up Three Per Day Jarrow Formulas
PureFormulas.com4.8(661)$28.99
Where to Buy Locally
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Optimum Health Supplements
4.9 (39)Vitamin & Supplements Shop
Unit 4 Phase, 2 Exchange Rd, Lincoln LN6 3JZ
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Clay St, Hull HU8 8HA
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Frederick Ward Way Friargate Freshney Place Shopping Centre 61, Grimsby DN31 1ED
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11 Chessingham Park, Dunnington, York YO19 5SE
Research & Studies
Nattokinase atherothrombotic prevention study: A randomized controlled trial
HN Hodis, WJ Mack, HJ Meiselman… - Clinical …, 2021 - content.iospress.com
… progression and cognitive aging in healthy men and women. … were provided gratis by Jarrow Formulas (Los Angeles, CA). … Lumen diameters were measured at the same site where …
202138 citationsOsteoporosis & Osteopenia: Vitamin Therapy for Stronger Bones
B Lusk - 2019 - books.google.com
… medical professional and their staff deserve recognition for their momentous contributions to our health … • Jarrow Formulas’ Zinc Balance consists of 15 mg of chelated zinc …
20191 citationsMulti-Method Screening of Commercial Antioxidant Supplements: Antioxidant Activity and Selected Antioxidant Compound Profiles
MC Iwona, K Karolina, C Monika, S Monika… - Foods, 2026 - researchgate.net
… of the health benefits of antioxidants has contributed to the expansion of the antioxidant supplement … The flow rate and injection volume were the same as in Method 1, and the column …
2026Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: a …
YL Dai, TH Luk, KH Yiu, M Wang, PMC Yip, SWL Lee… - Atherosclerosis, 2011 - Elsevier
AIMS: Coronary artery disease (CAD) is associated with endothelial dysfunction and mitochondrial dysfunction (MD). The aim of this study was to investigate whether co-enzyme Q10 (…
2011153 citationsAntioxidant and anti-hepatitis c viral activities of commercial milk thistle food supplements
K Anthony, G Subramanya, S Uprichard, F Hammouda… - Antioxidants, 2013 - mdpi.com
… their preparations, are used as part of the primary health care for 70%–95% of the population … External calibrated standards were made under the same condition for technical silymarin (…
201335 citationsUnlocking the potential of l‐α‐glycerylphosphorylcholine in the food industry: From safety approvals to market prospects
J Cao, E Su - Comprehensive Reviews in Food Science and …, 2025 - Wiley Online Library
… therapeutic potential for mental health-related disorders and … The utilization of l-α-GPC in dietary supplements and health … various choline supplements at the same choline equivalent …
20255 citations
Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2022-06-16. DSLD Label ID: 265054. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.
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