SAMe 400®
Non-Nutrient / Non-BotanicalBrand: Jarrow Formulas
Net Contents
30 Tablet(s)
Serving Size
1 Tablet(s)
Servings Per Container
30
Supplement Form
Tablet or Pill
Bar Code (UPC/SKU)
7 90011 20020 8
Product Version
06121SAM400 PROD # 120020
Label Analysis
Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.
Single-ingredient formula listed in Supplement Facts.
Every active ingredient discloses a specific amount per serving.
Label states: Vegan, Vegetarian, Gluten-Free.
This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.
Allergen Guide
Free From
- Wheat
- Gluten
Allergen flags are parsed automatically from the official label's claims and statements. Always verify against the physical product label before use, especially if you have a severe allergy.
Supplement Facts
Serving Size: 1 Tablet(s) · 1 per day
| Ingredient | Amount Per Serving | |
|---|---|---|
| S-Adenosyl Methionine | 400 mg | — |
| SAMe Tosylate Disulfate | 800 mg | — |
Not Present
Other Ingredients
Target Groups
Label Claims
Directions & Suggested Use
Suggested/Recommended/Usage/Directions
Usage: Take 1 tablet per day on an empty stomach or as directed by your qualified healthcare professional.
Suggested/Recommended/Usage/Directions
For best results, use with Jarrow Formulas JarroSil, the biologically Activated Silicon.
Warnings & Precautions
Precautions re: Pregnant or Nursing or Prescription Medications
Warning: Individuals using prescribed medications such as antidepressants, including Selective Serotonin Re-Uptake Inhibitors (SSRIs) and MAO Inhibitors should consult a physician before using this product. Individuals with Parkinson’s disease, bi-polar disorder or manic depression should not use SAMe. Do not use if pregnant or nursing.
Precautions re: All Other
Do not exceed recommended intake. May cause gastrointestinal upset in some persons. Consult a healthcare professional before using this product if you are trying to conceive, under the age of 18, or have a medical condition; if adverse reactions occur, discontinue use.
Precautions re: Children
Consult a healthcare professional before using this product if you are trying to conceive, under the age of 18, or have a medical condition; if adverse reactions occur, discontinue use.
Precautions re: All Other
Jarrow Formulas SAMe 400 is foil blister-packed to maximize stability and safety. Do not use if outer seal of blister pack is broken.
Precautions re: Children
Keep out of the reach of children.
Storage
Storage
Store in a cool, dry place.
Formulation
Formula re: Contains
Natural SAMe 400 Jarrow Formulas SAMe 400 provides a full 400 mg SAMe (net yield) from 800 mg of SAMe tosylate disulfate. SAMe 400 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product. Contains More of the Active S,S Form Found in all living cells, SAMe is a metabolite of methionine (an essential amino acid). SAMe is a chiral molecule consisting of two forms: (S,S) SAMe and (R,S) SAMe.
Formulation re: Other
The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive.
Formula re: Contains
Jarrow Formulas SAMe is made naturally by microbiological fermentation and then specially processed without chemical solvents to preserve 68-80% (S,S) SAMe, the highest active level available.
Formulation re: Other
SAMe supports: Joint Health SAMe supports the production of healthy connective tissue through transulfuration. In this process, critical components of connective tissue known as glycosaminoglycans (GAGs), including glucosamine and chondroitin, are sulfated by SAMe metabolites to yield sulfated GAGs, such as glucosamine sulfate and chondroitin sulfate. Brain Metabolism and Mood SAMe methylation reactions are involved in the synthesis of phosphatidylcholine, a substantial constituent of grey matter within the brain and cellular membranes and precursor to acetylcholine, as well as neurotransmitters such as dopamine, norepinephrine, and serotonin, and has been shown to have a positive effect on mood. Liver Function SAMe metabolism supports the synthesis of glutathione (GSH), which is critical for antioxidant defenses and liver functions including phase II detoxification.
Formula re: Contains
S-Adenosyl Methionine
Formulation re: Other
Full potency
Formula re: Contains
Full Potency 400 mg SAMe (net yield) is derived from 800 mg of SAMe tosylate disulfate.
Formula re: Contains
Natural pH-sensitive Food-grade EnteroGuard Coating
Formula re: Contains
S-Adenosyl Methionine 400 mg (net yield) SAMe from 800 mg SAMe tosylate disulfate Highest concentration of Active S,S Form
Formulation re: Other
Supports: Joint health Brain metabolism and mood Liver function
Formula re: Contains
Enteric-Coated Tablets
Formulation re: Does NOT Contain
No wheat, gluten, soybeans, dairy, egg, fish/shellfish, or peanuts/tree nuts.
Formula re: Contains
EnteroGuard is a proprietary cellulose-based, food-grade, pH-sensitive enteric coating that resists stomach acid and disintegrates in the less acidic pH of the upper intestines, where the SAMe is made available for absorption.
Formulation re: Does NOT Contain
Gluten free
Formulation re: Vegetarian/Vegan
V Vegan
FDA Statements
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Other Label Statements
Brand IP Statement(s) re: (c), (TM), (SM)
Copyright 2021 Jarrow Formulas
General Statements: All Other Content
In foil blister pack
Manufacturer & Distributor
Distributor
Jarrow Formulas
Los Angeles, CA, 90035-4317
1-866-459-4154
Market Reference
Jarrow Formulas SAM-e 400 60 Tablets
Jarrow Formulas4.7(442)$48.99Jarrow Formulas SAMe 400 mg - 30 Tablets - Highest Concentration of Active S,S Form - Supports Joint Health, Liver Function, Brain Metabolism, Mood &
GoSupps.com4.8(12)$54.99Jarrow Formulas Methyl Folate
Swanson Health Products4.8(12000)$10.09Jarrow Formulas Methyl Folate 400mcg folic acid 60 vegan capsules laboratory testing gluten-free vegetarian soybean without genetic
Pure Prescriptions$13.49SAMe 400 mg 100 Tablets
Cook's Natural Foods4.7(414)$59.99NOW Foods SAMe 400 mg 30 Tablets
PureFormulas.com4.7(414)$26.533 x Methyl Folate 400 Mcg 60 capsules - Jarrow Formulas
Naturitas$37.56Jarrow Formulas Bone Up Three Per Day 90 Capsules
Fruitful Yield4.8(661)$37.79
Where to Buy Locally
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Walgreens
2.7 (176)Vitamin & supplements store
425 Fuller Ave NE Walgreens, Grand Rapids, MI 49503
CVS Pharmacy
3.6 (52)Pharmacy
5120 28th St SE, Grand Rapids, MI 49512
Walgreens
3.3 (39)Vitamin & supplements store
800 Leonard St NW, Grand Rapids, MI 49504
CVS
3.5 (127)Vitamin & supplements store
727 28th St SE, Grand Rapids, MI 49548
Walgreens
3.2 (80)Vitamin & supplements store
378 Baldwin St, Jenison, MI 49428
CVS Pharmacy
3.8 (22)Pharmacy
5455 Clyde Park Ave SW, Wyoming, MI 49509
CVS
3.3 (75)Vitamin & supplements store
1550 Lake Dr SE, Grand Rapids, MI 49506
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3.8 (86)Vitamin & supplements store
3601 Clyde Park Ave SW, Wyoming, MI 49509
Research & Studies
… Study of Isothiocyanates and Other Bioactive Compounds of Brassica oleracea L. var. Italica Boiled or Steamed: Functional Food or Dietary Supplement?
P Orlando, A Nartea, S Silvestri, F Marcheggiani, I Cirilli… - Antioxidants, 2022 - mdpi.com
… method to promote the health benefits of broccoli in the diet. … % = 100), and the same amount of broccoli was cooked at 99 … 3 capsules of BroccoMax ® (Jarrow Formulas, California, LA, …
202228 citationsEfficacy of the Dietary Supplement S-Adenosyl-L-Methionine
CW Fetrow, JR Avila - Annals of Pharmacotherapy, 2001 - journals.sagepub.com
… A single oral dose of SAMe 400 mg … SAMe has been available for use in Europe for several years and is sold as a dietary supplement in the US under the Dietary Supplement Health …
200163 citationsRestoration of Blood Total Glutathione Status and Lymphocyte Function Following α-Lipoic Acid Supplementation in Patients with HIV Infection
RJ Jariwalla, J Lalezari, D Cenko… - … Integrative Health, 2008 - journals.sagepub.com
… group were given ALA supplement (ALA 300 sustain, provided by Jarrow Formulas, Los Angeles, CA) at a dose of 300 mg three times daily for 6 months. Patients in the control group …
200868 citationsNatural Digestive Care That's Easy to Swallow
K Chiarello-Ebner - wholefoodsmagazine.com
… of Health Sciences and consultant to Jarrow Formulas, Los … moisture, Jarrow Formulas’ Jarro-Dophilus EPS supplement is … to find a formula with multiple strains of the same enzyme in …
Taking Back Control
T Person - wholefoodsmagazine.com
… Jarrow Formulas) has been shown to aid insulin with blood sugar regulation, while other forms of HCA have not shown the same … that supplement manufacturers and natural health …
Lactoferrin and Probiotic-Derived Supernatants as Adjuvants for Managing Multidrug-Resistant Opportunistic Infections
DA Costea, VA Badaluta, LI Magheran, LI Vasiliu… - 2026 - preprints.org
… Opportunistic bacteria are key drivers of healthcare… from LAB cultures were tested for the same activities. Finally, the … the association between commercial Lf (Jarrow Formulas, USA) and …
20261 citations
Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2022-06-16. DSLD Label ID: 265053. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.
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