SAMe 400®
Non-Nutrient / Non-BotanicalBrand: Jarrow Formulas
Net Contents
30 Tablet(s)
Serving Size
1 Tablet(s)
Servings Per Container
30
Supplement Form
Tablet or Pill
Bar Code (UPC/SKU)
7 90011 20020 8
Product Version
12119SAM400 PROD # 120020
Label Analysis
Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.
Single-ingredient formula listed in Supplement Facts.
Every active ingredient discloses a specific amount per serving.
Label states: Vegan, Vegetarian, Gluten-Free.
This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.
Allergen Guide
Free From
- Wheat
Allergen flags are parsed automatically from the official label's claims and statements. Always verify against the physical product label before use, especially if you have a severe allergy.
Supplement Facts
Serving Size: 1 Tablet(s) · 1 per day
| Ingredient | Amount Per Serving | |
|---|---|---|
| S-Adenosyl Methionine(SAM-e Tosylate Disulfate) | 400 mg | — |
Not Present
Other Ingredients
Target Groups
Label Claims
Directions & Suggested Use
Suggested/Recommended/Usage/Directions
Usage: Take 1 tablet per day on an empty stomach or as directed by your qualified healthcare professional.
Suggested/Recommended/Usage/Directions
For best results, use with Jarrow Formulas JarroSil, the biologically Activated Silicon.
Warnings & Precautions
Precautions re: Pregnant or Nursing or Prescription Medications
Warning: Individuals using prescribed medications such as antidepressants, including Selective Serotonin Re-Uptake Inhibitors (SSRIs) and MAO Inhibitors should consult a physician before using this product.
Precautions re: All Other
Individuals with Parkinson’s disease, bi-polar disorder or manic depression should not use SAMe.
Precautions re: Pregnant or Nursing or Prescription Medications
Do not use if pregnant or nursing.
Precautions re: All Other
Do not exceed recommended intake. May cause gastrointestinal upset in some persons. If you experience discomfort, discontinue use.
Precautions re: Children
Keep out of the reach of children.
Storage
Storage
Store in a cool, dry place.
Formulation
Formulation re: Other
Full potency
Formula re: Contains
Full potency 400 mg SAMe (net yield) is derived from 800 mg of SAMe tosylate disulfate.
Formulation re: Other
pH-sensitive - food grade enteroguard coating
Formula re: Contains
S-Adenosyl Methionine 400 mg (net yield) SAMe from 800 mg SAMe tosylate disulfate Highest concentration of Active S,S Form
Formulation re: Other
Promotes: Joint strength Liver detoxification Mood and brain function Enteric-coated tablets
Formulation re: Vegetarian/Vegan
Suitable for vegetarians/vegans.
Formulation re: Does NOT Contain
No wheat, gluten, soybeans, dairy, egg, fish/shellfish, or peanuts/tree nuts.
Formulation re: Other
EnteroGuard is a proprietary cellulose-based, food-grade, pH-sensitive enteric coating that resists stomach acid and disintegrates in the less acidic pH of the upper intestines, where the SAMe is made available for absorption.
Formula re: Contains
Jarrow Formulas SAMe 400 provides a full 400 mg SAMe (net yield) from 800 mg of SAMe tosylate disulfate. SAMe 400 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product. Contains more of the active S,S form Found in all living cells, SAMe is a metabolite of methionine (an essential amino acid). SAMe is a chiral molecule consisting of two forms: (S,S) SAMe and (R,S) SAMe. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive. Jarrow Formulas SAMe is made naturally by microbiological fermentation and then specially processed without chemical solvents to preserve 68-80% (S,S) SAMe, the highest active level available.
Formulation re: Other
SAMe has been clinically shown to have the following benefits: Joint Strength SAMe supports the production of healthy connective tissue through transulfuration. In this process, critical components of connective tissue known as glycosaminoglycans (GAGs), including glucosamine and chondroitin, are sulfated by SAMe metabolites to yield sulfated GAGs, such as glucosamine sulfate and chondroitin sulfate. Brain Metabolism SAMe methylation reactions are involved in the synthesis of neurotransmitters such as L-DOPA, dopamine and related hormones, serotonin, epinephrine and phosphatidylcholine (a component of lecithin). Liver SAMe metabolism supports the synthesis of glutathione (GSH) and glutathione-dependent enzymes (glutathione peroxidase, glutathione reductase and glutathione-S-transferase), which are components of the body’s endogenous antioxidant network and important for liver function, including phase II detoxification.
FDA Statements
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Other Label Statements
General Statements: All Other Content
Jarrow Formulas SAMe 400 is foil blister-packed to maximize stability and safety. Do not use if outer seal of blister pack is broken.
Seals/Symbols
V Vegan
Brand IP Statement(s) re: (c), (TM), (SM)
2019 Jarrow Formulas
Manufacturer & Distributor
Distributor
Jarrow Formulas Superior Nutrition and Formulation
Los Angeles, CA, 90035-4317
(866) 459-4154
Market Reference
Jarrow Formulas SAM-e 400 60 Tablets
Jarrow Formulas4.7(442)$48.99Jarrow Formulas SAMe 400 mg - 30 Tablets - Highest Concentration of Active S,S Form - Supports Joint Health, Liver Function, Brain Metabolism, Mood &
GoSupps.com4.8(12)$54.99Jarrow Formulas Methyl Folate
Swanson Health Products4.8(12000)$10.09Jarrow Formulas Methyl Folate 400mcg folic acid 60 vegan capsules laboratory testing gluten-free vegetarian soybean without genetic
Pure Prescriptions$13.49NOW Foods SAMe 400 mg 30 Tablets
PureFormulas.com4.7(414)$26.53SAMe 400 mg 100 Tablets
Cook's Natural Foods4.7(414)$59.993 x Methyl Folate 400 Mcg 60 capsules - Jarrow Formulas
Naturitas$37.56Protocol For Life Balance SAMe 400mg 60 Tablets
Summit Natural Wellness Center4.9(36)$75.00
Where to Buy Locally
Enter your city or ZIP code to find supplement & health stores in your area that may carry this product.
Showing representative supplement & health retailers — search above for stores in your area.
Walgreens
2.7 (109)Drug store
1450 S Hwy 97, Redmond, OR 97756
Research & Studies
… Study of Isothiocyanates and Other Bioactive Compounds of Brassica oleracea L. var. Italica Boiled or Steamed: Functional Food or Dietary Supplement?
P Orlando, A Nartea, S Silvestri, F Marcheggiani, I Cirilli… - Antioxidants, 2022 - mdpi.com
… method to promote the health benefits of broccoli in the diet. … % = 100), and the same amount of broccoli was cooked at 99 … 3 capsules of BroccoMax ® (Jarrow Formulas, California, LA, …
202228 citationsEfficacy of the Dietary Supplement S-Adenosyl-L-Methionine
CW Fetrow, JR Avila - Annals of Pharmacotherapy, 2001 - journals.sagepub.com
… A single oral dose of SAMe 400 mg … SAMe has been available for use in Europe for several years and is sold as a dietary supplement in the US under the Dietary Supplement Health …
200163 citationsRestoration of Blood Total Glutathione Status and Lymphocyte Function Following α-Lipoic Acid Supplementation in Patients with HIV Infection
RJ Jariwalla, J Lalezari, D Cenko… - … Integrative Health, 2008 - journals.sagepub.com
… group were given ALA supplement (ALA 300 sustain, provided by Jarrow Formulas, Los Angeles, CA) at a dose of 300 mg three times daily for 6 months. Patients in the control group …
200868 citationsNatural Digestive Care That's Easy to Swallow
K Chiarello-Ebner - wholefoodsmagazine.com
… of Health Sciences and consultant to Jarrow Formulas, Los … moisture, Jarrow Formulas’ Jarro-Dophilus EPS supplement is … to find a formula with multiple strains of the same enzyme in …
Taking Back Control
T Person - wholefoodsmagazine.com
… Jarrow Formulas) has been shown to aid insulin with blood sugar regulation, while other forms of HCA have not shown the same … that supplement manufacturers and natural health …
Lactoferrin and Probiotic-Derived Supernatants as Adjuvants for Managing Multidrug-Resistant Opportunistic Infections
DA Costea, VA Badaluta, LI Magheran, LI Vasiliu… - 2026 - preprints.org
… Opportunistic bacteria are key drivers of healthcare… from LAB cultures were tested for the same activities. Finally, the … the association between commercial Lf (Jarrow Formulas, USA) and …
20261 citations
Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2021-02-25. DSLD Label ID: 243542. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.
Related Products
01-02-Go
Pure Nootropics
100% Caffeine
MuscleTech
100% Creatine Unflavored
Six Star Pro Nutrition
100% Creatine Unflavored
Six Star Pro Nutrition