SAM-e 400 mg®
Non-Nutrient / Non-BotanicalBrand: Jarrow Formulas
Net Contents
60 Tablet(s)
Serving Size
1 Tablet(s)
Servings Per Container
60
Supplement Form
Tablet or Pill
Bar Code (UPC/SKU)
7 90011 20042 0
Product Version
04415SAM460 PROD # 120042
Label Analysis
Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.
Single-ingredient formula listed in Supplement Facts.
Every active ingredient discloses a specific amount per serving.
Label states: Vegan, Vegetarian, Gluten-Free.
This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.
Allergen Guide
Free From
- Milk
- Egg
- Fish
- Peanut
- Wheat
- Soy
- Gluten
Allergen flags are parsed automatically from the official label's claims and statements. Always verify against the physical product label before use, especially if you have a severe allergy.
Supplement Facts
Serving Size: 1 Tablet(s) · 1 per day
| Ingredient | Amount Per Serving | |
|---|---|---|
| S-Adenosyl Methionine | 400 mg | — |
| SAM-e Tosylate Disulfate | 800 mg | — |
Not Present
Other Ingredients
Target Groups
Label Claims
Directions & Suggested Use
Suggested/Recommended/Usage/Directions
USAGE: Take 1 tablet per day on an empty stomach or as directed by your qualified healthcare professional.
Suggested/Recommended/Usage/Directions
For best results, use with Jarrow Formulas JarroSil, the biologically Activated Silicon.
Warnings & Precautions
Precautions re: Pregnant or Nursing or Prescription Medications
WARNING: Individuals using prescribed medications such as antidepressants, including Selective Serotonin Re-Uptake Inhibitors (SSRIs) and MAO Inhibitors should consult a physician before using this product.
Precautions re: All Other
Individuals with Parkinson’s disease, bi-polar disorder or manic depression should not use SAM-e.
Precautions re: Pregnant or Nursing or Prescription Medications
Do not use if pregnant or nursing.
Precautions re: All Other
Do not exceed recommended intake. May cause gastrointestinal upset in some persons. If you experience discomfort, discontinue use.
Precautions re: All Other
DO NOT use if outer seal of blister pack is broken.
Precautions re: Children
Keep out of the reach of children.
Storage
Storage
Store in a cool, dry place.
Formulation
Formula re: Contains
SAM-e S-Adenosyl Methionine 400 FULL POTENCY
Formula re: Contains
Full Potency 400 mg SAM-e (net yield) is derived from 800 mg of SAM-e tosylate disulfate.
Formula re: Contains
S-ADENOSYL METHIONINE 400 mg (net yield) SAM-e from 800 mg SAM-e tosylate disulfate Highest Concentration of Active S,S Form
Formula re: Contains
NET YIELD 400 MG SAM-e
Formulation re: Vegetarian/Vegan
Suitable for vegetarians/vegans.
Formulation re: Does NOT Contain
No wheat, no gluten, no soybeans, no dairy, no egg, no fish/shellfish, no peanuts/tree nuts.
Formula re: Contains
Natural SAM-e 400 Jarrow Formulas SAM-e 400 provides a full 400 mg SAM-e (net yield) from 800 mg of SAM-e tosylate disulfate.
FDA Statements
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Other Label Statements
Brand IP Statement(s) re: (c), (TM), (SM)
Jarrow Formulas SAM-e 400 is foil blister-packed to maximize stability and safety.
General Statements: All Other Content
NEW HIGHER COUNT In Foil Blister Pack Natural
General Statements: All Other Content
Promotes: Joint Strength* Liver Detoxification* Mood and Brain Function* Enteric-Coated Tablets
Seals/Symbols
GLUTEN FREE
Seals/Symbols
v vegan
Brand IP Statement(s) re: (c), (TM), (SM)
Superior Nutrition and Formulation
Brand IP Statement(s) re: (c), (TM), (SM)
2015 Jarrow Formulas
General Statements: All Other Content
SAM-e 400 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product. Contains More of the Active S,S Form Found in all living cells, SAM-e is a metabolite of methionine (an essential amino acid). SAM-e is a chiral molecule and consists of two forms: (S,S) SAM-e and (R,S) SAM-e. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive.
Brand IP Statement(s) re: (c), (TM), (SM)
Jarrow Formulas SAM-e is made naturally by microbiological fermentation and then specially processed without chemical solvents to preserve 68-80% (S,S) SAM-e, the highest active level available.
General Statements: All Other Content
SAM-e has been clinically shown to have the following benefits: Joint Strength SAM-e supports the production of healthy connective tissue through transulfuration.* In this process, critical components of connective tissue, known as glycosaminoglycans (GAGs), including glucosamine and chondroitin, are sulfated by SAM-e metabolites to yield sulfated GAGs, such as glucosamine sulfate and chondroitin sulfate.* Brain Metabolism SAM-e methylation reactions are involved in the synthesis of neurotransmitters such as L-DOPA, dopamine and related hormones, serotonin, epinephrine and phosphatidylcholine (a component of lecithin).* Liver SAM-e metabolism supports the synthesis of glutathione (GSH) and glutathione-dependent enzymes (glutathione peroxidase and glutathione-S-transferase), which are substances important for liver function, including phase II detoxification.*
General: Product/Version Code
04415SAM460 PROD # 120042
Manufacturer & Distributor
Distributor
Jarrow Formulas
P.O. Box 35994, Los Angeles, CA, 90035-4317
Market Reference
Jarrow Formulas SAM-e 400 60 Tablets
Jarrow Formulas4.7(442)$48.99Jarrow Formulas SAMe 400 mg - 30 Tablets - Highest Concentration of Active S,S Form - Supports Joint Health, Liver Function, Brain Metabolism, Mood &
GoSupps.com4.8(12)$54.99Nature Made SAM-e Complete 400 mg
Swanson Health Products4.5(310)$49.77Carlyle SAM-e 400mg 30 Tablets
Target4.5(6)$20.99LowestSAMe 400 mg - 60 tabs
Nutriessential.com$64.79NOW Foods Sun-E 400 Softgels
NOW4.7(228)$49.99Jarrow Formulas Softgels
My Dr. XM4.6(11)$78.50SAMe 400mg - Dr. Kevin Passero
Green Healing Wellness$39.95
Where to Buy Locally
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Supplements With Science LLC - Corporate Headquarters
4.9 (10)Vitamin & supplements store
1100 Peachtree St NE Suite 200, Atlanta, GA 30309
The Vitamin Shoppe
3.9 (212)Vitamin & supplements store
1209 Caroline St NE, Atlanta, GA 30307
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4.8 (174)Vitamin & supplements store
6597-G Roswell Rd NE, Sandy Springs, GA 30328
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3.6 (56)Vitamin & supplements store
650 Ponce De Leon Ave NE #640-A, Atlanta, GA 30308
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5.0 (5)Vitamin & supplements store
6700 Dawson Blvd, Norcross, GA 30093
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4.8 (58)Vitamin & supplements store
1544 Piedmont Rd NE Ste 318, Atlanta, GA 30324
Vitamins and Beyond
5.0 (1)Vitamin & supplements store
3015 RN Martin St #131, East Point, GA 30344
The Vitamin Shoppe
4.3 (158)Vitamin & supplements store
3261 Peachtree Rd, Atlanta, GA 30305
Research & Studies
S-Adenosylmethionine (SAMe) for Central Nervous System Health: A Systematic Review
KER Baden, H McClain, E Craig, N Gibson, JA Draime… - Nutrients, 2024 - mdpi.com
… 400 mg once or twice daily, 400 mg daily titrated to 800 mg twice daily for ADHD, and 400 mg daily titrated to 800 mg … For depression, SAMe was dosed between 200 and 3200 mg daily, …
202410 citationsThe SAM-e Solution: The Essential Guide to the Revolutionary Antidepression Supplement
D Mitchell - 2000 - books.google.com
… SAM-e levels are characteristic of many different medical conditions, which are discussed at length in this book. They also found that levels of SAM-e … blood levels of SAM-e than women, …
20004 citations… of a novel oral formulation of S-adenosylmethionine (MSI-195) in healthy subjects: dose escalation, food effect and comparison to a commercial nutritional supplement …
BR Cameron, L Ferreira, ID MacDonald - BMC Pharmacology and …, 2020 - Springer
… MSI discovered that formulations of SAM-e including propyl gallate have enhanced … has a dosage strength of 400 mg (based on the weight of the free base). The SAM-e counter-ions are …
202014 citationsDietary supplements: Evaluation and application in clinical practice
CA Thomson, T Newton - Topics in Clinical Nutrition, 2005 - journals.lww.com
… support of SAM-e in depression treatment are stronger than that for St John's wort. SAM-e has … , she may discontinue St John's wort and continue SAM-e at 400 mg twice daily. One final …
20059 citationsUtility of nutraceutical products marketed for cognitive and memory enhancement
GJ McDougall Jr, V Austin-Wells… - Journal of Holistic …, 2005 - journals.sagepub.com
… Sam-e is a shortening of the technical name and is trademarked under this name. Sam-e is used as a nutritional supplement … One study indicated that Sam-e was superior to a placebo …
200519 citationsRestoration of Blood Total Glutathione Status and Lymphocyte Function Following α-Lipoic Acid Supplementation in Patients with HIV Infection
RJ Jariwalla, J Lalezari, D Cenko… - … Integrative Health, 2008 - journals.sagepub.com
… group were given ALA supplement (ALA 300 sustain, provided by Jarrow Formulas, Los Angeles, CA) at a dose of 300 mg three times daily for 6 months. Patients in the control group …
200868 citations
Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2015-10-22. DSLD Label ID: 51387. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.
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