Spermidine 5 mg

Suggested Use

Suggested use: As a dietary supplement; take two (2) capsules once a day; with at least 8 oz. of water or as directed by a healthcare professional.

• 

  Dr. Emil Nutrition Spermidine

  Dr. Emil Nutrition4.8(153)

  $48.95
• 

  Spermidine Value Pack

  Dr. Emil Nutrition

  $78.95
• 

  NMN Healthy Aging Bundle

  Dr. Emil Nutrition

  $86.95
• 

  Spermidine Supplement Ultra High Strength Standardized to 99% Spermidine Trihydrochloride. More Potent Than Wheat Germ Extract. Vegan Capsules

  Walmart - Peak Performance

  $21.95Lowest

Enter your city or ZIP code to find supplement & health stores in your area that may carry this product.

Showing representative supplement & health retailers — search above for stores in your area.

• Pure Essentials Supplements

  5.0 (1)

  Vitamin & supplements store

  121 Varick St, New York, NY 10013

  Directions(212) 758-3200

• HiLife Vitamins

  4.6 (166)

  Vitamin & supplements store

  48 River Rd, Chatham, NJ 07928

  Directions(800) 622-8877

• Spermidine Mitigates Immune Cell Senescence and Boosts Vaccine Responses in Healthy Older Adults—A Pilot Study

  G Alsaleh, M Ali, AH Kayvanjoo, F Liu, T Moreau… - Aging …, 2026 - Wiley Online Library

  2026

• Circadian clock control by polyamine levels through a mechanism that declines with age

  Z Zwighaft, R Aviram, M Shalev, L Rousso-Noori… - Cell metabolism, 2015 - cell.com

  … Here we show that certain diets can be in fact beneficial for circadian rhythmicity and that supplementation of spermidine in the diet can maintain the circadian period in adult mice, …

  2015193 citations

• Spermidine supplementation protects the liver endothelium from liver damage in mice

  G Camprecios, M Ruart, A Anton, N Suarez-Herrera… - Nutrients, 2021 - mdpi.com

  … of dietary supplementation with SPD in two models of liver disease (CCl 4 and CDAAH diet). … This study suggests SPD diet supplementation in early phases of disease protects the liver …

  202117 citations

• Spermidine restricts neonatal inflammation via metabolic shaping of polymorphonuclear myeloid-derived suppressor cells

  J Chen, L Zhu, Z Cui, Y Zhang, R Jia, D Zhou… - The Journal of Clinical …, 2025 - jci.org

  … After the cessation of nutrient supply from the cord blood at … However, the exact role of spermidine in neonatal health … Supplementation with spermidine or spermidine-generated PMN-…

  20254 citations

• The Diet–Microbiota–Polyamine Axis in Intestinal Aging: Microbial Pathways, Functional Foods, and Physiological Implications

  AN Mafe, D Büsselberg - Nutrients, 2026 - mdpi.com

  20263 citations

• A study of the cardioprotective effect of spermidine: A novel inducer of autophagy

  EM Omar, RS Omar, MS Shoela… - Journal of Physiological …, 2021 - journals.lww.com

  … sequel of spermidine supplementation on postinfarction … Myocardial infarction is a major public health problem and … autophagy are metabolic stress and nutrient deprivation.[ 8 ] …

  202112 citations

Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2025-01-23. DSLD Label ID: 321811. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.