Methyl Folate L-5-MTHF®

Vitamins

Brand: Douglas Laboratories

Tablet or PillVitaminOff Market

Product label for Methyl Folate L-5-MTHF — Click to view full label

Net Contents

60 Tablet(s)

Serving Size

1 Tablet(s)

Servings Per Container

Supplement Form

Tablet or Pill

Bar Code (UPC/SKU)

3 10539 03762 1

Product Version

Formula #201181

Label Analysis

Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.

1Active Ingredients

Single-ingredient formula listed in Supplement Facts.

100%Amount Transparency

Every active ingredient discloses a specific amount per serving.

1% Daily Value Coverage

1 ingredients report a %DV; 1 meet or exceed 100% DV.

1Dietary Attributes

Label states: Gluten-Free.

This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.

Allergen Guide

Contains

Milk
Wheat
Soy
Gluten

Allergen flags are parsed automatically from the official label's claims and statements. Always verify against the physical product label before use, especially if you have a severe allergy.

Supplement Facts

Serving Size: 1 Tablet(s) · 1 per day

Ingredient	Amount Per Serving	% Daily Value
Folate(L-Methylfolate)	1000 mcg	250%

Not Present

Other Ingredients

CelluloseDicalcium PhosphateCroscarmellose SodiumVegetable StearateSilica

Target Groups

Adult (18 - 50 Years)Gluten FreeDairy FreeSugar Free

Label Claims

All Other

Directions & Suggested Use

Suggested/Recommended/Usage/Directions

Suggested Usage: As a dietary supplement, adults take 1 tablet daily, or as directed by your healthcare professional.

Warnings & Precautions

Precautions re: Children

KEEP OUT OF REACH OF CHILDREN.

Precautions re: All Other

Tamper resistant package, do not use if outer seal is missing.

Storage

For optimal storage conditions, store in a cool, dry place. (59(0) - 77(0)F/15(0) - 25(0)C) (35-65% relative humidity)

Formulation

Formulation re: Does NOT Contain

This product contains NO yeast, wheat, gluten, soy, milk/dairy, corn, sugar, starch, artificial preservatives, artificial flavoring, or genetically modified organisms (GMOs).

Formula re: Contains

1,000 mcg Metafolin

FDA Statements

FDA Statement of Identity

A Dietary Supplement

Other Label Statements

Brand IP Statement(s) re: (c), (TM), (SM)

Metafolin is a registered trademark of Merck KGaA, Darmstadt, Germany.

General: Product/Version Code

Formula #201181

Manufacturer & Distributor

Distributor

Douglas Laboratories

600 Boyce Road, Pittsburgh, PA, 15205, USA

1.800.245.4440

Market Reference

$7.99 – $229.99· 40 listings

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Fresh Nutrition L Methyl Folate 7.5mg
Walmart - Fresh Nutrition Inc5.0(2)
$16.99
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Where to Buy Locally

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Protein Zone
4.5 (161)
Vitamin & supplements store
20 Abbey Street Upper, North City, Dublin 1, D01 DE00
Directions 087 393 6603
Holland & Barrett - Rathmines
3.9 (28)
Vitamin & supplements store
Unit 23 Rathmines Rd Lower, Swan Centre, Rathmines, Dublin, D06 F4W8
Directions 1800 901 595
Vitamin Shop Dublin 2
4.9 (48)
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41 Aungier St, Dublin 2, D02 T028
Directions 087 774 2195
SO Nutrition
4.0 (55)
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Unit 47, Moore Mall, Ilac Centre, Henry St, Dublin 1, D01 X497
Directions (01) 872 7945
Vitamin Shop Blanchardstown
4.7 (60)
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COOLMINE BUSINESS PARK UNIT 105A, DUBLIN 15 Dublin, Blanchardstown, Dublin
Directions 085 158 8107
Holland & Barrett
3.8 (109)
Vitamin & supplements store
45 Henry St, North City, Dublin 1, D01 E9X8
Directions (01) 517 6229
Holland & Barrett - Grafton Street
3.9 (75)
Vitamin & supplements store
75 Grafton Street, Dublin, D02 YV32
Directions 1800 901 595
Holland & Barrett - Dundrum
4.3 (27)
Vitamin & supplements store
Unit 27, Dundrum Town Centre, Sandyford Rd, Dundrum, Dublin, D16 PN81
Directions 1800 901 595

Research & Studies

SUGGESTED USE
NGMO Gluten-free - oakwaynaturals.com
… Methyl Folate supplies 5 mg (5,000 mcg) of biologically active folate called Metafolin® (6S) 5methyltetrahydrofolate (5-MTHF). 5-MTHF is directly usable by the body and has been …
Preclinical safety evaluation of sodium L-methylfolate
K Morris-Schaffer, S Dahlberg, E Johann… - Food and Chemical …, 2025 - Elsevier
… studies on calcium L-methylfolate (L-5-MTHF-Ca). In conclusion, L-5-MTHF-Na is shown to have an overall safe profile for its use as a dietary source of folate for nutritional purposes. …
20252 citations
Supplementation with folic acid or 5-methyltetrahydrofolate and prevention of neural tube defects: an evidence-based narrative review
ML Samaniego-Vaesken, C Morais-Moreno… - Nutrients, 2024 - mdpi.com
… be converted into L-5-MTHF in a reaction catalysed by the methylenetetrahydrofolate reductase (MTHFR) [38]. The resulting L-5-MTHF is the predominant form of folate found in plasma …
202426 citations
L-5-methyltetrahydrofolate supplementation increases blood folate concentrations to a greater extent than folic acid supplementation in Malaysian women
AM Henderson, RE Aleliunas, SP Loh, GL Khor… - The Journal of …, 2018 - Elsevier
… The objective of this study was to determine the effects of folic acid or l-5-MTHF supplementation on blood folate concentrations, methyl nutrient metabolites, and DNA methylation in …
201835 citations
Suitability and safety of L-5-methyltetrahydrofolate as a folate source in infant formula: A randomized-controlled trial
B Troesch, J Demmelmair, M Gimpfl, C Hecht… - PloS one, 2019 - journals.plos.org
… that unmetabolized folic acid may have adverse health effects, … of using L-5-MTHF as an alternative folate source for infant … and safety of L-5-MTHF as a folate source in infant formula. …
201948 citations
Sensory Acceptability and Nutrient Stability in Micronutrient-Fortified Soymilk Prepared in Small-Scale Batch Processes
DM Hardy - 2019 - search.proquest.com
… Doug Heiner, whose generous donation made the Ecuador portion of the project possible. I’m deeply grateful to my advising committee for their oversight and invaluable assistance – …
2019

Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2016-03-24. DSLD Label ID: 57008. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.