Methyl Folate L-5-MTHF®

Vitamins

Brand: Douglas Laboratories

Tablet or PillVitaminOff Market

Product label for Methyl Folate L-5-MTHF — Click to view full label

Net Contents

60 Tablet(s)

Serving Size

1 Tablet(s)

Servings Per Container

Supplement Form

Tablet or Pill

Bar Code (UPC/SKU)

3 10539 03762 1

Product Version

Formula #201181

Label Analysis

Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.

1Active Ingredients

Single-ingredient formula listed in Supplement Facts.

100%Amount Transparency

Every active ingredient discloses a specific amount per serving.

1% Daily Value Coverage

1 ingredients report a %DV; 1 meet or exceed 100% DV.

1Dietary Attributes

Label states: Gluten-Free.

This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.

Allergen Guide

Contains

Milk
Soy
Gluten

Allergen flags are parsed automatically from the official label's claims and statements. Always verify against the physical product label before use, especially if you have a severe allergy.

Supplement Facts

Serving Size: 1 Tablet(s) · 1 per day

Ingredient	Amount Per Serving	% Daily Value
Folate(L-Methylfolate)	1000 mcg	250%

Not Present

Other Ingredients

CelluloseDicalcium PhosphateCroscarmellose SodiumVegetable StearateSilica

Target Groups

Adult (18 - 50 Years)Gluten Free

Label Claims

All Other

Directions & Suggested Use

Suggested/Recommended/Usage/Directions

Suggested Usage: As a dietary supplement, adults take 1 tablet daily, or as directed by your healthcare professional.

Warnings & Precautions

Precautions re: Children

KEEP OUT OF REACH OF CHILDREN.

Precautions re: All Other

Tamper resistant package, do not use if outer seal is missing.

Storage

For optimal storage conditions, store in a cool, dry place. (59(0) - 77(0)F/15(0) - 25(0)C) (35-65% relative humidity)

Formulation

Formulation re: Does NOT Contain

This product contains NO yeast, gluten, soy protein, milk/dairy, corn, sugar, starch, artificial coloring, preservatives or flavoring.

FDA Statements

FDA Statement of Identity

A Dietary Supplement

Other Label Statements

General: Product/Version Code

Formula #201181

Brand IP Statement(s) re: (c), (TM), (SM)

1,000 mcg Metafolin(R)

Brand IP Statement(s) re: (c), (TM), (SM)

Metafolin(R) is a registered trademark of Merck KGaA, Darmstadt, Germany.

Manufacturer & Distributor

Manufacturer

Douglas Laboratories

600 Boyce Road, Pittsburgh, PA, 15205, USA

1.800.245.4440

Market Reference

$7.99 – $2399.99· 40 listings

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$29.99
365 by Whole Foods Market Methyl Folate 100 Count
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$9.79
5-MTHF 5mg
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$68.00
Jarrow Formulas Methyl Folate
Grove Collaborative4.8(12000)
$7.99Lowest
Triquetra L-Methyl B12 Capsules
Macy's4.7(159)
$17.99

Where to Buy Locally

Enter your city or ZIP code to find supplement & health stores in your area that may carry this product.

Showing representative supplement & health retailers — search above for stores in your area.

Southern Nutrition
5.0 (228)
Vitamin & supplements store
10458 Stelling Dr, Riverview, FL 33578
Directions (813) 610-8457
GNC
3.5 (34)
Vitamin & supplements store
3830 Sun City Center Blvd Ste 101, Sun City Center, FL 33573
Directions (813) 642-8600
Southern Nutrition
5.0 (1420)
Vitamin & supplements store
2940 Providence Lakes Blvd, Brandon, FL 33511
Directions (813) 330-7760
Foundation Supplements
4.8 (37)
Vitamin & supplements store
3409 W Bay to Bay Blvd, Tampa, FL 33629
Directions
The Vitamin Shoppe
4.4 (215)
Vitamin & supplements store
102 N Dale Mabry Hwy, Tampa, FL 33609
Directions (813) 874-3107
Nutrishop Valrico
4.9 (153)
Vitamin & supplements store
3240 Lithia Pinecrest Rd #103, Valrico, FL 33596
Directions (813) 684-2380
GNC
3.1 (65)
Vitamin & supplements store
10655 Big Bend Rd Ste 208, Riverview, FL 33579
Directions (813) 741-1000
The Vitamin Shoppe
4.4 (217)
Vitamin & supplements store
Plaza at, 101 Brandon Town Center Dr, Brandon, FL 33511
Directions (813) 643-1010

Research & Studies

SUGGESTED USE
NGMO Gluten-free - oakwaynaturals.com
… Methyl Folate supplies 5 mg (5,000 mcg) of biologically active folate called Metafolin® (6S) 5methyltetrahydrofolate (5-MTHF). 5-MTHF is directly usable by the body and has been …
Preclinical safety evaluation of sodium L-methylfolate
K Morris-Schaffer, S Dahlberg, E Johann… - Food and Chemical …, 2025 - Elsevier
… studies on calcium L-methylfolate (L-5-MTHF-Ca). In conclusion, L-5-MTHF-Na is shown to have an overall safe profile for its use as a dietary source of folate for nutritional purposes. …
20252 citations
Supplementation with folic acid or 5-methyltetrahydrofolate and prevention of neural tube defects: an evidence-based narrative review
ML Samaniego-Vaesken, C Morais-Moreno… - Nutrients, 2024 - mdpi.com
… be converted into L-5-MTHF in a reaction catalysed by the methylenetetrahydrofolate reductase (MTHFR) [38]. The resulting L-5-MTHF is the predominant form of folate found in plasma …
202426 citations
L-5-methyltetrahydrofolate supplementation increases blood folate concentrations to a greater extent than folic acid supplementation in Malaysian women
AM Henderson, RE Aleliunas, SP Loh, GL Khor… - The Journal of …, 2018 - Elsevier
… The objective of this study was to determine the effects of folic acid or l-5-MTHF supplementation on blood folate concentrations, methyl nutrient metabolites, and DNA methylation in …
201835 citations
Suitability and safety of L-5-methyltetrahydrofolate as a folate source in infant formula: A randomized-controlled trial
B Troesch, J Demmelmair, M Gimpfl, C Hecht… - PloS one, 2019 - journals.plos.org
… that unmetabolized folic acid may have adverse health effects, … of using L-5-MTHF as an alternative folate source for infant … and safety of L-5-MTHF as a folate source in infant formula. …
201948 citations
Sensory Acceptability and Nutrient Stability in Micronutrient-Fortified Soymilk Prepared in Small-Scale Batch Processes
DM Hardy - 2019 - search.proquest.com
… Doug Heiner, whose generous donation made the Ecuador portion of the project possible. I’m deeply grateful to my advising committee for their oversight and invaluable assistance – …
2019

Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2012-02-23. DSLD Label ID: 5304. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.