L-5-MTHF 5 mg®
Non-Nutrient / Non-BotanicalBrand: Designs for Health
Net Contents
60 Vegetarian Capsule(s)
Serving Size
1 Capsule(s)
Servings Per Container
Not specified
Supplement Form
Capsule
Bar Code (UPC/SKU)
8 79452 00398 9
Product Version
MTH060
Label Analysis
Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.
Single-ingredient formula listed in Supplement Facts.
Every active ingredient discloses a specific amount per serving.
1 ingredients report a %DV; 1 meet or exceed 100% DV.
Label states: Non-GMO, Gluten-Free.
This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.
Supplement Facts
Serving Size: 1 Capsule(s) · 1 per day
| Ingredient | Amount Per Serving | % Daily Value |
|---|---|---|
| Folate(Quatrefolic(R) (6S)-5-methyltetrahydrofolate) | 5 mg | 1250% |
| Glucosamine Salt | 10 mg | — |
Not Present
Other Ingredients
Target Groups
Label Claims
Directions & Suggested Use
Suggested/Recommended/Usage/Directions
Recommended Use: As a dietary supplement, take one capsule per day, or as directed by your health care practitioner.
Warnings & Precautions
Precautions re: Children
KEEP OUT OF REACH OF CHILDREN.
Storage
Storage
STORE IN A COOL, DRY PLACE.
Formulation
Formulation re: Does NOT Contain
Does not contain gluten.
Formula re: Contains
Natural S-Isomer
Formula re: Contains
L-5-MTHF is a natural, biologically active form of folate. It offers the benefits of optimal folate supplementation without the potential risks associated with chronic exposure to unmetabolized synthetic folic acid.
FDA Statements
FDA Statement of Identity
Dietary Supplement
Other Label Statements
General Statements: All Other Content
Notice: Color, size or shape may appear different between lots.
General: Product/Version Code
MTH060
General Statements: All Other Content
For Professional Use Only
General Statements: All Other Content
Manufactured in a GMP Audited Facility in Arlee, MT, USA
Brand IP Statement(s) re: (c), (TM), (SM)
Quatrefolic(R) is covered by U.S. Patent No. 7,947,662 and is a registered trademark of Gnosis S.p.A.
Seals/Symbols
Quatrefolic(R)
Seals/Symbols
MADE WITH NON-GMO INGREDIENTS
Seals/Symbols
Guaranteed GMP COMPLIANT Products
Manufacturer & Distributor
Manufacturer
Designs for Health, Inc.
980 South Street, Suffield, CT, 06078
Market Reference
Designs for Health L-5-MTHF
Supplement First4.7(30)$91.49Thorne Research 5-MTHF 5mg 60 Capsules
Thorne4.8(506)$68.005 Methylfolate 5-mthf L-Methylfolate 5 mg
methyl-life.com4.7(43)$44.005-MTHF 5000 mcg
REX Genetics$29.9910x Health 5 Mthf Supplement
Walmart - 10X Health Ventures4.2(97)$27.50Designs For Health 5-HTP Supreme 60 Capsules
Supplement First4.8(8)$52.995MG L-5 MTHF By Intelligent Labs L-5 Methylfolate Activated Folic Acid Supplement as Quatrefolic Acid
Intelligent Labs4.8(7)$36.99Rho Nutrition Liposomal Methylfolate 5 MTHF + B12 Complex
Rho Nutrition4.8(103)$39.95
Where to Buy Locally
Enter your city or ZIP code to find supplement & health stores in your area that may carry this product.
Showing representative supplement & health retailers — search above for stores in your area.
ITL Health
5.0 (37)Vitamin & Supplements Shop
50 Broadway, London SW1H 0BL
RightNutri
4.9 (78)Vitamin & Supplements Shop
26 Queenstown Rd, London SW8 3RX
Protiv Nutrition
5.0 (1)Vitamin & Supplements Shop
3rd Floor, 207 Regent St., London W1B 3HH
London Supplements
3.7 (84)Vitamin & Supplements Shop
13, Waverley Industrial Park Waverley Industrial Estate, Hailsham Dr, Harrow HA1 4TR
Research & Studies
… reductase genotype determines the plasma homocysteine-lowering effect of supplementation with 5-methyltetrahydrofolate or folic acid in healthy young …
IP Fohr, R Prinz-Langenohl, A Brönstrup… - The American journal of …, 2002 - Elsevier
… The polymorphism in the gene encoding 5,10-methylenetetrahydrofolate reductase (FADH 2 … plasma tHcy, but limited data are available on the effect of 5-methyltetrahydrofolate (MTHF). …
2002179 citationsEffect of L-Methylfolate Supplementation on Sleep for Patients with Reduced Methylenetetrahydrofolate Reductase Activity
AS Carmon, RJ Amato, SM Patel… - Journal of Dietary …, 2024 - Taylor & Francis
… the effects of L-5-MTHF supplementation on sleep in a cohort … at a dose of 5 mg daily; and (5) completion of PROMIS-43 … the cohort, the retrospective design, and the predominance …
20243 citations… with microencapsulated L-5-methyltetrahydrofolic acid or equimolar folic acid increase blood folate concentrations to a similar extent in healthy men and women
TJ Green, Y Liu, S Dadgar, W Li, R Böhni… - The Journal of …, 2013 - academic.oup.com
… that microencapsulation of L-5-MTHF with sodium ascorbate using … L-5-MTHF loss during bread making and storage (17). The bioavailability in humans of microencapsulated L-5-MTHF …
201340 citationsConversion of calcium-l-methylfolate and (6S)-5-methyltetrahydrofolic acid glucosamine salt into dietary folate equivalents
D Turck, T Bohn, J Castenmiller, S De Henauw… - EFSA …, 2022 - iris.unimore.it
… A free form of L-5-MTHF acid (500 μg) was consumed as a supplement on an empty stomach. The bioavailability of 5-MTHF was estimated in urine samples by reference to the …
202223 citationsSuitability and safety of L-5-methyltetrahydrofolate as a folate source in infant formula: A randomized-controlled trial
B Troesch, J Demmelmair, M Gimpfl, C Hecht… - PloS one, 2019 - journals.plos.org
… fed a formula containing L-5-MTHF compared to infants fed a … We aimed to assess the suitability and safety of L-5-MTHF as … randomized controlled study design following good clinical …
201948 citationsSupplementation with folic acid or 5-methyltetrahydrofolate and prevention of neural tube defects: an evidence-based narrative review
ML Samaniego-Vaesken, C Morais-Moreno… - Nutrients, 2024 - mdpi.com
… Supplementation with high FA doses (1–5 mg/day) is recommended … -5-MTHF in a reaction catalysed by the methylenetetrahydrofolate reductase (MTHFR) [38]. The resulting L-5-MTHF …
202426 citations
Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2014-04-25. DSLD Label ID: 31978. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.
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