Brand: Designs for Health

CapsuleNon-Nutrient/Non-BotanicalOn Market
Click to view full label

Net Contents

60 Vegetarian Capsule(s)

Serving Size

1 Capsule(s)

Servings Per Container

Not specified

Supplement Form

Capsule

Bar Code (UPC/SKU)

8 79452 00398 9

Product Version

MTH060

Label Analysis

Objective insights generated automatically from the official DSLD label — a quick, factual read of how this product is formulated and disclosed.

1Active Ingredients

Single-ingredient formula listed in Supplement Facts.

100%Amount Transparency

Every active ingredient discloses a specific amount per serving.

1% Daily Value Coverage

1 ingredients report a %DV; 1 meet or exceed 100% DV.

2Dietary Attributes

Label states: Non-GMO, Gluten-Free.

This analysis is generated algorithmically from label data for educational reference only. It is not a product endorsement, ranking, or medical advice.

Supplement Facts

Serving Size: 1 Capsule(s) · 1 per day

IngredientAmount Per Serving% Daily Value
Folate(Quatrefolic(R) (6S)-5-methyltetrahydrofolate)5 mg1250%
Glucosamine Salt10 mg

Not Present

Other Ingredients

Microcrystalline Cellulosespinach juice powderL-Leucine

Target Groups

Adult (18 - 50 Years)Gluten Free

Label Claims

All Other

Directions & Suggested Use

Suggested/Recommended/Usage/Directions

Recommended Use: As a dietary supplement, take one capsule per day, or as directed by your health care practitioner.

Warnings & Precautions

Precautions re: Children

KEEP OUT OF REACH OF CHILDREN.

Storage

Storage

STORE IN A COOL, DRY PLACE.

Formulation

Formulation re: Does NOT Contain

Does not contain gluten.

Formula re: Contains

Natural S-Isomer

Formula re: Contains

L-5-MTHF is a natural, biologically active form of folate. It offers the benefits of optimal folate supplementation without the potential risks associated with chronic exposure to unmetabolized synthetic folic acid.

FDA Statements

FDA Statement of Identity

Dietary Supplement

Other Label Statements

General Statements: All Other Content

Notice: Color, size or shape may appear different between lots.

General: Product/Version Code

MTH060

General Statements: All Other Content

For Professional Use Only

General Statements: All Other Content

Manufactured in a GMP Audited Facility in Arlee, MT, USA

Brand IP Statement(s) re: (c), (TM), (SM)

Quatrefolic(R) is covered by U.S. Patent No. 7,947,662 and is a registered trademark of Gnosis S.p.A.

Seals/Symbols

Quatrefolic(R)

Seals/Symbols

MADE WITH NON-GMO INGREDIENTS

Seals/Symbols

Guaranteed GMP COMPLIANT Products

Manufacturer & Distributor

Manufacturer

Designs for Health, Inc.

980 South Street, Suffield, CT, 06078

Market Reference

$16.00 – $191.76· 40 listings
  • Designs for Health L-5-MTHF

    Supplement First4.7(30)
    $91.49
  • Thorne Research 5-MTHF 5mg 60 Capsules

    Thorne4.8(506)
    $68.00
  • 5 Methylfolate 5-mthf L-Methylfolate 5 mg

    methyl-life.com4.7(43)
    $44.00
  • 5-MTHF 5000 mcg

    REX Genetics
    $29.99
  • 10x Health 5 Mthf Supplement

    Walmart - 10X Health Ventures4.2(97)
    $27.50
  • Designs For Health 5-HTP Supreme 60 Capsules

    Supplement First4.8(8)
    $52.99
  • 5MG L-5 MTHF By Intelligent Labs L-5 Methylfolate Activated Folic Acid Supplement as Quatrefolic Acid

    Intelligent Labs4.8(7)
    $36.99
  • Rho Nutrition Liposomal Methylfolate 5 MTHF + B12 Complex

    Rho Nutrition4.8(103)
    $39.95

Where to Buy Locally

Enter your city or ZIP code to find supplement & health stores in your area that may carry this product.

Showing representative supplement & health retailers — search above for stores in your area.

  • ITL Health

    5.0 (37)

    Vitamin & Supplements Shop

    50 Broadway, London SW1H 0BL

  • RightNutri

    4.9 (78)

    Vitamin & Supplements Shop

    26 Queenstown Rd, London SW8 3RX

  • Protiv Nutrition

    5.0 (1)

    Vitamin & Supplements Shop

    3rd Floor, 207 Regent St., London W1B 3HH

  • London Supplements

    3.7 (84)

    Vitamin & Supplements Shop

    13, Waverley Industrial Park Waverley Industrial Estate, Hailsham Dr, Harrow HA1 4TR

Research & Studies

  • … reductase genotype determines the plasma homocysteine-lowering effect of supplementation with 5-methyltetrahydrofolate or folic acid in healthy young …

    IP Fohr, R Prinz-Langenohl, A Brönstrup… - The American journal of …, 2002 - Elsevier

    … The polymorphism in the gene encoding 5,10-methylenetetrahydrofolate reductase (FADH 2 … plasma tHcy, but limited data are available on the effect of 5-methyltetrahydrofolate (MTHF). …

    2002179 citations
  • Effect of L-Methylfolate Supplementation on Sleep for Patients with Reduced Methylenetetrahydrofolate Reductase Activity

    AS Carmon, RJ Amato, SM Patel… - Journal of Dietary …, 2024 - Taylor & Francis

    … the effects of L-5-MTHF supplementation on sleep in a cohort … at a dose of 5 mg daily; and (5) completion of PROMIS-43 … the cohort, the retrospective design, and the predominance …

    20243 citations
  • … with microencapsulated L-5-methyltetrahydrofolic acid or equimolar folic acid increase blood folate concentrations to a similar extent in healthy men and women

    TJ Green, Y Liu, S Dadgar, W Li, R Böhni… - The Journal of …, 2013 - academic.oup.com

    … that microencapsulation of L-5-MTHF with sodium ascorbate using … L-5-MTHF loss during bread making and storage (17). The bioavailability in humans of microencapsulated L-5-MTHF …

    201340 citations
  • Conversion of calcium-l-methylfolate and (6S)-5-methyltetrahydrofolic acid glucosamine salt into dietary folate equivalents

    D Turck, T Bohn, J Castenmiller, S De Henauw… - EFSA …, 2022 - iris.unimore.it

    … A free form of L-5-MTHF acid (500 μg) was consumed as a supplement on an empty stomach. The bioavailability of 5-MTHF was estimated in urine samples by reference to the …

    202223 citations
  • Suitability and safety of L-5-methyltetrahydrofolate as a folate source in infant formula: A randomized-controlled trial

    B Troesch, J Demmelmair, M Gimpfl, C Hecht… - PloS one, 2019 - journals.plos.org

    … fed a formula containing L-5-MTHF compared to infants fed a … We aimed to assess the suitability and safety of L-5-MTHF as … randomized controlled study design following good clinical …

    201948 citations
  • Supplementation with folic acid or 5-methyltetrahydrofolate and prevention of neural tube defects: an evidence-based narrative review

    ML Samaniego-Vaesken, C Morais-Moreno… - Nutrients, 2024 - mdpi.com

    … Supplementation with high FA doses (1–5 mg/day) is recommended … -5-MTHF in a reaction catalysed by the methylenetetrahydrofolate reductase (MTHFR) [38]. The resulting L-5-MTHF …

    202426 citations

Data sourced from the U.S. National Institutes of Health, Office of Dietary Supplements Dietary Supplement Label Database (DSLD) · Label entered 2014-04-25. DSLD Label ID: 31978. This information is provided for educational reference only and is not medical advice. Always follow the product label and consult a doctor or pharmacist before use.